SOX2-associated signaling pathways regulate biological phenotypes of cancers

Ding, Li; Yu, Youlin; Ma, Chao; Lei, Cai-yun; Zhang, H.B.

doi:10.1016/j.biopha.2023.114336

Cited by 11 publications

(5 citation statements)

References 164 publications

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“…S5g ) gene signatures. Focusing here on other selected genes associated with inflammation and stemness, we confirmed that MUC1-C and XIST regulate expression of ATF2 [ 48 ], SOX2 [ 49 ], BMI1 [ 20 ] and WNT5A [ 50 ] (Fig. 5g ) genes.…”

Section: Resultsmentioning

confidence: 52%

XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression

Wang,

Bhattacharya,

Haratake

et al. 2024

Cell Death Dis

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The long non-coding RNA X-inactive specific transcript (lncRNA XIST) and MUC1 gene are dysregulated in chronic inflammation and cancer; however, there is no known interaction of their functions. The present studies demonstrate that MUC1-C regulates XIST lncRNA levels by suppressing the RBM15/B, WTAP and METTL3/14 components of the m6A methylation complex that associate with XIST A repeats. MUC1-C also suppresses the YTHDF2-CNOT1 deadenylase complex that recognizes m6A sites and contributes to XIST decay with increases in XIST stability and expression. In support of an auto-regulatory pathway, we show that XIST regulates MUC1-C expression by promoting NF-κB-mediated activation of the MUC1 gene. Of significance, MUC1-C and XIST regulate common genes associated with inflammation and stemness, including (i) miR-21 which is upregulated across pan-cancers, and (ii) TDP-43 which associates with the XIST E repeats. Our results further demonstrate that the MUC1-C/XIST pathway (i) is regulated by TDP-43, (ii) drives stemness-associated genes, and (iii) is necessary for self-renewal capacity. These findings indicate that the MUC1-C/XIST auto-regulatory axis is of importance in cancer progression.

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Section: Resultsmentioning

confidence: 52%

XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression

Wang,

Bhattacharya,

Haratake

et al. 2024

Cell Death Dis

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“…7 H). Abnormal expression of SOX2 was shown to be intricately linked to the occurrence, differentiation, metastasis, and poor prognosis of malignant tumors 19 , 20 . We performed KEGG enrichment analysis on the 73 differential proteins and observed that these DEPs were enriched in multiple signaling pathways of cancer, such as the RAS, MAPK signaling pathway, PI3K-AKT signaling pathway, and Hippo signaling pathway (Fig.…”

Section: Resultsmentioning

confidence: 99%

Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer

Liu,

Wang,

Guo

et al. 2024

Sci Rep

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BAZ2A, an epigenetic regulatory factor that affects ribosomal RNA transcription, has been shown to be highly expressed in several cancers and promotes tumor cell migration. This study explored the expression and mechanism of BAZ2A in tumorigenesis at the pan-cancer level. The Cancer Genome Atlas, Gene Expression Omnibus databases and TIMER2.0, cBioPortal and other tools were used to analyze the level of expression of BAZ2A in various tumor tissues and to examine the relationship between BAZ2A and survival, prognosis, mutation and immune invasion. In vitro experiments were performed to assess the function of BAZ2A in cancer cells. Using combined transcriptome and proteome analysis, we examined the possible mechanism of BAZ2A in tumors. BAZ2A exhibited high expression levels in multiple tumor tissues and displayed a significant association with cancer patient prognosis. The main type of BAZ2A genetic variation in cancer is gene mutation. Downregulation of BAZ2A inhibited proliferation, migration, and invasion and promoted apoptosis in LM6 liver cancer cell. The mechanism of BAZ2A in cancer development may involve lipid metabolism. These results help expand our understanding of BAZ2A in tumorigenesis and development and suggest BAZ2A may serve as a prognostic and diagnostic factor in several cancers.

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“…Indeed, the genetic instability evident in hiPSCs and their RPE derivatives was a key factor leading to the suspension of the AMD clinical trial at RIKEN 10 . It is possible that the genetic factors utilized in hiPSC generation may have contributed to this phenomenon, as evidenced by their upregulated expression in various tumor types [27][28][29] . In contrast, chemical induction avoids the use of genetic factors; therefore, future studies should explore whether hCiPSCs could bypass the potential safety issues associated with overexpression of genetic factors.…”

Section: Discussionmentioning

confidence: 99%

Efficient differentiation of human retinal pigment epithelium cells from chemically induced pluripotent stem cells

Zhang,

Wang,

et al. 2024

Preprint

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Human induced pluripotent stem cells (hiPSCs) hold considerable promise for autologous cellular therapies, particularly in ocular disease treatment, because of the low numbers of cells required for transplantation and the non-invasive nature of graft monitoring. However, the use of hiPSCs in ocular disease treatment faces challenges because the production of clinical-grade autologous hiPSCs via genetic techniques remains expensive, time-consuming, and subject to safety concerns. Here, we utilize a recently reported chemical method to derive human chemically induced pluripotent stem cells (hCiPSCs), demonstrating that hiPSC lines can be generated using small molecules in a simple and robust manner. Moreover, we show that these cell lines can be efficiently differentiated into retinal pigment epithelium (RPE) cells, which may aid in the treatment of age-related macular degeneration (AMD). Our study provides a foundation for cost-effective, fast, and safe methods that enable efficient production of autologous retinal cell types for ocular disease treatment.

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SOX2-associated signaling pathways regulate biological phenotypes of cancers

Cited by 11 publications

References 164 publications

XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression

XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression

Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer

Efficient differentiation of human retinal pigment epithelium cells from chemically induced pluripotent stem cells

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