SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis

Swain, Niharika; Thakur, Mansee; Pathak, Jigna; Swain, Biswaranjan

doi:10.4103/jomfp.jomfp_22_20

Cited by 47 publications

(30 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cells expressing SOX2 could not be detected in normal parathyroid glands from normocalcemic subjects, but normal glands showed rare cells expressing OCT4 and NANOG. This observation resembles the few cells expressing core stem genes detected in normal oral epithelial cells or in cells of oral premalignant lesions [29]. Cells expressing the core stem genes were detected in a subset of parathyroid adenomas and in most parathyroid carcinomas.…”

Section: Discussionsupporting

confidence: 67%

The Core Stem Genes SOX2, POU5F1/OCT4, and NANOG Are Expressed in Human Parathyroid Tumors and Modulated by MEN1, YAP1, and β-catenin Pathways Activation

et al. 2021

View full text Add to dashboard Cite

Tumors of the parathyroid glands are the second most common endocrine neoplasia. Epigenetic studies revealed an embryonic signature involved in parathyroid tumorigenesis. Here, we investigated the expression of the stem core genes SOX2, POU5F1/OCT4, and NANOG. Rare cells within normal parathyroid glands expressed POU5F1/OCT4 and NANOG, while SOX2 was undetectable. Nuclear SOX2 expression was detectable in 18% of parathyroid adenomas (PAds, n = 34) involving 5–30% of cells, while OCT4 and NANOG were expressed at the nuclear level in a more consistent subset of PAds involving 15–40% of cells. Most parathyroid carcinomas expressed the core stem genes. SOX2-expressing cells co-expressed parathormone (PTH). In PAds-derived primary cultures, silencing of the tumor suppressor gene MEN1 induced the expression of SOX2, likely through a MEN1/HAR1B/SOX2 axis, while calcium-sensing receptor activation increased SOX2 mRNA levels through YAP1 activation. In addition, inducing nuclear β-catenin accumulation in PAds-derived primary cultures by short-term incubation with lithium chloride (LiCl), SOX2 and POU5F1/OCT4 expression levels increased, while NANOG transcripts were reduced, and LiCl long-term incubation induced an opposite pattern of gene expression. In conclusion, detection of the core stem genes in parathyroid tumors supports their embryogenic signature, which is modulated by crucial genes involved in parathyroid tumorigenesis.

show abstract

Section: Discussionsupporting

confidence: 67%

The Core Stem Genes SOX2, POU5F1/OCT4, and NANOG Are Expressed in Human Parathyroid Tumors and Modulated by MEN1, YAP1, and β-catenin Pathways Activation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…64 The attractive concept of CSCs, which holds that this population of cancer cells endowed with self-renewal and tumour-seeding potential could drive cancer initiation and progression, has been widely recognised. 62,65 Importantly, this concept provides an explanation for cancer heterogeneity that confers resistance to chemotherapeutic drugs, radiotherapy, targeted therapy and immunotherapy, accounting for the poor survival of LUAD patients. 66 Our previous studies have suggested that EHD1 plays roles in chemoresistance and EGFR-TKI resistance.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, the upregulated CD44 inhibits Hippo signalling activity, leading to nuclear entry of dephosphorylated YAP as well as a subsequent increase in the expression of downstream target genes (i.e. OCT4, SOX2, Nanog, CTGF and CYR61, which are related to stemness and/or EMT) 51,62 . Thus, EHD1 antagonises the Hippo pathway to enhance the CSCs‐like properties, EMT and metastasis of LUAD cells.…”

Section: Discussionmentioning

confidence: 99%

A novel EHD1/CD44/Hippo/SP1 positive feedback loop potentiates stemness and metastasis in lung adenocarcinoma

Liu

Song

Cao

et al. 2022

Clinical & Translational Med

View full text Add to dashboard Cite

1. EHD1 interacts with the CD44-ICD, promoting CD44 recycling and upregulating CD44 expression. 2. CD44 upregulation inhibits Hippo signalling activity, activating expression of downstream target genes involved in stemness and EMT. 3. SP1, as a downstream target of Hippo signalling, in turn transcriptionally activates EHD1 expression, finally forming an EHD1/CD44/Hippo/SP1 positive feedback loop that drives LUAD metastasis.

show abstract

“…CSCs or tumor-initiating cells (TICs) represent a sub-population of cells that exhibit self-renewal ability and the capacity to differentiate. The undifferentiated state is maintained through the transcriptional regulation of four major transcription factors: SOX2, OCT4, and NANOG [ 74 , 75 , 76 , 77 ]. Moreover, compared with normal stem cells, CSCs are highly clonogenic.…”

Section: Cancer Stem Cells In Metastasismentioning

confidence: 99%

Metastasis and MAPK Pathways

Kciuk

Gielecińska

Budzinska

et al. 2022

IJMS

View full text Add to dashboard Cite

Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growth or the induction of cell death, and do not consider the molecular basis of metastasis. The aim of this work is to provide a comprehensive review focusing on cancer metastasis and the mitogen-activated protein kinase (MAPK) pathway (ERK/JNK/P38 signaling) as a crucial modulator of this process.

show abstract

SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis

Cited by 47 publications

References 28 publications

The Core Stem Genes SOX2, POU5F1/OCT4, and NANOG Are Expressed in Human Parathyroid Tumors and Modulated by MEN1, YAP1, and β-catenin Pathways Activation

The Core Stem Genes SOX2, POU5F1/OCT4, and NANOG Are Expressed in Human Parathyroid Tumors and Modulated by MEN1, YAP1, and β-catenin Pathways Activation

A novel EHD1/CD44/Hippo/SP1 positive feedback loop potentiates stemness and metastasis in lung adenocarcinoma

Metastasis and MAPK Pathways

Contact Info

Product

Resources

About