Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

Tchougounova, Elena; Jiang, Yiwen; Bråsäter, Daniel; Lindberg, Nanna; Kastemar, Marianne; Asplund, Anna; Westermark, Bengt; Uhrbom, Lene

doi:10.1038/onc.2009.9

Cited by 31 publications

(34 citation statements)

References 38 publications

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“…In human glioma cell lines the expression of Sox5 was low and overexpression of Sox5 reduced the clone formation and the cell proliferation was inhibited. The mechanism by which Sox5 suppresses PDGFB-induced gliomas is suggested to be due to immediate cellular senescence through regulation of p27 Kip and Akt (Tchougounova, et al, 2009). Another report confirms that Sox5 expression is lower in oligodendroglial and astrocytic tumours compared to the already low expression in normal adult brain (Schlierf, et al, 2007).…”

Section: The Feature Of Soxd Proteins In Glioma and Medulloblastoma 3supporting

confidence: 66%

“…The integration sites suggest that Sox5 expression can be upregulated or truncated which can result in a truncated protein or no product at all (Johansson, et al, 2004). In the follow-up study by Tchougonova et al, Sox5 is suggested to be a suppressor gene in PDGFB-induced gliomas predominantly in the Ink4a-deficient mouse background (Tchougounova, et al, 2009). In human glioma cell lines the expression of Sox5 was low and overexpression of Sox5 reduced the clone formation and the cell proliferation was inhibited.…”

Section: The Feature Of Soxd Proteins In Glioma and Medulloblastoma 3mentioning

confidence: 99%

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The Role of Sox Transcription Factors in Brain Tumourigenesis

Ferletta¹

2011

Molecular Targets of CNS Tumors

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Section: The Feature Of Soxd Proteins In Glioma and Medulloblastoma 3supporting

confidence: 66%

Section: The Feature Of Soxd Proteins In Glioma and Medulloblastoma 3mentioning

confidence: 99%

The Role of Sox Transcription Factors in Brain Tumourigenesis

Ferletta¹

2011

Molecular Targets of CNS Tumors

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“…Cellular senescence can inhibit tumor formation by modulating the redox state in CSCs and by regulating p27 in glioma cells (26,27). In addition, GICs derived from wild-type mice expressing the senescence-promoting factor esophageal cancer-related gene 4 (Ecrg4) caused significantly reduced tumor formation in mouse brains compared with cells from Ecrg4-knockdown mice (28).…”

Section: Discussionmentioning

confidence: 99%

miR340 Suppresses the Stem-like Cell Function of Glioma-Initiating Cells by Targeting Tissue Plasminogen Activator

et al. 2015

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Glioma-initiating cells (GIC) have stem-like cell properties thought to be sufficient for recurrence, progression, and drug resistance in glioblastomas. In the present study, we defined miRNA (miR)-340 as a differentially expressed miRNA in human GICs that inhibit GIC-mediated tumorigenesis. Furthermore, we defined tissue plasminogen activator (PLAT) as a critical direct target of miR340 for inhibition. Among miRNAs screened, we found that miR340 expression was decreased in all human GICs and in human glioblastoma tissues, compared with human neural stem cells and normal brain tissues. miR340 overexpression in GICs suppressed their proliferative, invasive, and migratory properties in vitro, triggering cell senescence in vitro and inhibiting GIC-induced tumorigenesis in mouse brains. shRNA-mediated silencing of PLAT in GICs phenocopied the effects of miR340 overexpression in vitro and in vivo, suggesting a potential role for tissue factor in stem-like cell function. Taken together, our results identified miR340 as a tumor suppressor that functions in GIC to enforce PLAT blockade and ablate their stem-like functions.

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“…SOX5 is a member of the high-mobility group superfamily and is reportedly overexpressed in several malignancies, including nasopharyngeal carcinoma and prostate cancer, which suggests it has oncogenic properties (31,32). On the other hand, one recent study showed that SOX5 suppresses plateletderived growth factor B-induced gliomas (33). GALNT14 belongs to a large subfamily of glycosyltransferases, and its expression in cancer cells is associated with cellular sensitivity to the proapoptotic ligand Apo2L/TRAIL (34).…”

Section: Discussionmentioning

confidence: 99%

Aberrant Methylation of RASGRF1 Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer

Takamaru

Yamamoto

Suzuki

et al. 2012

Cancer Prevention Research

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Aberrant DNA methylation is implicated in the epigenetic field defect seen in gastric cancer. Our aim in this study was to identify predictive biomarkers by screening for DNA methylation in noncancerous background gastric mucosa from patients with gastric cancer. Using methylated-CpG island amplification coupled with CpG island microarray (MCAM) analysis, we identified 224 genes that were methylated in the noncancerous gastric mucosa of patients with gastric cancer. Among them, RASGRF1 methylation was significantly elevated in gastric mucosa from patients with either intestinal or diffuse type gastric cancer, as compared with mucosa from healthy individuals (8.3% vs. 22.4%, P < 0.001; 8.3% vs. 19.4%, P < 0.001). RASGRF1 methylation was independent of mucosal atrophy and could be used to distinguish both serum pepsinogen test-positive [sensitivity, 70.0%; specificity, 86.7%; area under the receiver operator characteristic (ROC) curve, AUC, 0.763] and -negative patients with gastric cancer (sensitivity, 72.2%; specificity, 87.0%; AUC, 0.844) from healthy individuals. Ectopic expression of RASGRF1 suppressed colony formation and Matrigel invasion by gastric cancer cells, suggesting it may be involved in gastric tumorigenesis. Collectively, our data suggest that RASGRF1 methylation is significantly involved in an epigenetic field defect in the stomach, and that it could be a useful biomarker to identify individuals at high risk for gastric cancer. Cancer Prev Res; 5(10); 1203-12. Ó2012 AACR.

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Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

Cited by 31 publications

References 38 publications

The Role of Sox Transcription Factors in Brain Tumourigenesis

The Role of Sox Transcription Factors in Brain Tumourigenesis

miR340 Suppresses the Stem-like Cell Function of Glioma-Initiating Cells by Targeting Tissue Plasminogen Activator

Aberrant Methylation of RASGRF1 Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer

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