SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells

Sun, Qi‐Yun; Ding, Ling-Wen; Johnson, Kara; Zhou, Shiwei; Tyner, Jeffrey W.; Yang, Henry; Doan, Ngan; Said, Jonathan; Xiao, Jin; Loh, Xin Yi; Ran, Xue Bin; Venkatachalam, Nachiyappan; Lao, Zhentang; Chen, Ye; Xu, Lu; Fan, Li Fei; Chien, Wenwen; Lin, De; Koeffler, H. Phillip

doi:10.1038/s41388-019-0865-8

Cited by 42 publications

(24 citation statements)

References 57 publications

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“…Panobinostat elevates Sry-box transcription factor 7 (SOX7) expression and suppresses lung cancer cell proliferation. Mechanically, SOX7 triggers apoptosis by preventing Bim from proteasome-mediated degradation ( Sun et al, 2019 ). The N-terminal truncated form of p63, ΔNp63, belongs to the p53 family, but acts as an oncoprotein.…”

Section: Biological Functions Of Hdacsmentioning

confidence: 99%

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Guo

Tian

Zhu

2020

Front. Cell Dev. Biol.

199

135

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Genetic mutations and abnormal gene regulation are key mechanisms underlying tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores, represent the basic units of chromatin. The fifth amino group (N ε) of histone lysine residues is a common site for post-translational modifications (PTMs), and of these, acetylation is the second most common. Histone acetylation is modulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), and is involved in the regulation of gene expression. Over the past two decades, numerous studies characterizing HDACs and HDAC inhibitors (HDACi) have provided novel and exciting insights concerning their underlying biological mechanisms and potential anti-cancer treatments. In this review, we detail the diverse structures of HDACs and their underlying biological functions, including transcriptional regulation, metabolism, angiogenesis, DNA damage response, cell cycle, apoptosis, protein degradation, immunity and other several physiological processes. We also highlight potential avenues to use HDACi as novel, precision cancer treatments.

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Section: Biological Functions Of Hdacsmentioning

confidence: 99%

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Guo

Tian

Zhu

2020

Front. Cell Dev. Biol.

199

135

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“…In addition, we have validated here the downregulation of the MAPK/ERK pathway upon PIM inhibition in HCC cells. The MAPK/ERK pathway is a known deregulated pathway in human cancers and plays a role in cancer progression and chemoresistance [34][35][36][37][38]. We noted a relatively less pronounced suppression of pERK1/2 upon PIM inhibitor treatment in vitro (supplementary material, Figure S7B), which might hint that other cell types in the tumour microenvironment are involved in the process.…”

Section: Discussionmentioning

confidence: 88%

Anti‐tumour effects of PIM kinase inhibition on progression and chemoresistance of hepatocellular carcinoma

Leung

Chan

Dai

et al. 2020

The Journal of Pathology

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Hepatocellular carcinoma (HCC) is a biologically aggressive cancer. Targeted therapy is in need to tackle challenges in the treatment perspective. A growing body of evidence suggests a promising role of pharmacological inhibition of PIM (proviral integration site for Moloney murine leukaemia virus) kinase in some human haematological and solid cancers. Yet to date, the potential application of PIM inhibitors in HCC is still largely unexplored. In the present study we investigated the pre‐clinical efficacy of PIM inhibition as a therapeutic approach in HCC. Effects of PIM inhibitors on cell proliferation, migration, invasion, chemosensitivity, and self‐renewal were examined in vitro. The effects of PIM inhibitors on tumour growth and chemoresistance in vivo were studied using xenograft mouse models. Potential downstream molecular mechanisms were elucidated by RNA sequencing (RNA‐seq) of tumour tissues harvested from animal models. Our findings demonstrate that PIM inhibitors SGI‐1776 and PIM447 reduced HCC proliferation, metastatic potential, and self‐renewal in vitro. Results from in vivo experiments supported the role of PIM inhibition in suppressing of tumour growth and increasing chemosensitivity of HCC toward cisplatin and doxorubicin, the two commonly used chemotherapeutic agents in trans‐arterial chemoembolisation (TACE) for HCC. RNA‐seq analysis revealed downregulation of the MAPK/ERK pathway upon PIM inhibition in HCC cells. In addition, LOXL2 and ICAM1 were identified as potential downstream effectors. Taken together, PIM inhibitors demonstrated remarkable anti‐tumourigenic effects in HCC in vitro and in vivo. PIM kinase inhibition is a potential approach to be exploited in formulating adjuvant therapy for HCC patients of different disease stages. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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“…78 In addition, cumulative studies have shown that activation of ERK-related signaling leads to tumor formation and progression and is considered a promising target for tumor treatment. [79][80][81] Elevated expression of circRNA MYLK in BC enhances sponging of miR-29a to activate VEGFA/VEGFR2 and the downstream Ras/ERK signaling pathway, which promotes tumor development. 82 In addition, circRNA001418 is overexpressed in BC, thus reducing the miR-1297 level; this reduction results in an increase in EphA2 expression to activate the downstream ERK1/ERK2 signaling pathway, which promotes tumor progression.…”

Section: Classical Tumor Signaling Pathwaysmentioning

confidence: 99%

<p>Circular RNAs and Bladder Cancer</p>

Cai

2020

OTT

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Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat to human health. Circular RNAs (circRNAs) are members of a newly defined class of noncoding RNAs (ncRNAs) that can regulate gene expression at the transcriptional or posttranscriptional level. Studies have shown that circRNAs are related to the clinicopathological characteristics, prognosis, and chemosensitivity of BC, and basic research has further confirmed that changes in the expression of circRNAs in BC are closely related to various tumor biological functions. CircRNAs promote tumor development by interacting with miRNAs to regulate transcription factors and both classical and nonclassical tumor signaling pathways. The nonclassical signaling pathways are related to cell cycle progression, epithelial-mesenchymal transition (EMT), extracellular matrix maintenance, and tumor stem cell maintenance. In this article, the relationships between circRNAs and the clinical characteristics of BC are reviewed, and the molecular mechanisms by which circRNAs promote tumor development are explored.

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SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells

Cited by 42 publications

References 57 publications

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Anti‐tumour effects of PIM kinase inhibition on progression and chemoresistance of hepatocellular carcinoma

<p>Circular RNAs and Bladder Cancer</p>

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