2014
DOI: 10.3390/jcdd1020163
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Sox9- and Scleraxis-Cre Lineage Fate Mapping in Aortic and Mitral Valve Structures

Abstract: Heart valves are complex structures composed of a heterogeneous population of valve interstitial cells (VICs), an overlying endothelium and highly organized layers of extracellular matrix. Alterations in valve homeostasis are characteristic of dysfunction and disease, however the mechanisms that initiate and promote valve pathology are poorly understood. Advancements have been largely hindered by the limited availability of tools for gene targeting in heart valve structures during embryogenesis and after birth… Show more

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