Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects

Mirahmadi, Seyed-Mohamad-Sadegh; Shahmohammadi, Alireza; Rousta, Ali Mohammad; Azadi, Mohammad-Reza; Fahanik-Babaei, Javad; Baluchnejadmojarad, Tourandokht; Roghani, Mehrdad

doi:10.1016/j.cyto.2017.10.008

Cited by 79 publications

(53 citation statements)

References 92 publications

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“…Meanwhile, GE administration markedly counteracted the oxidative stress damage, which might partly explain the beneficial effects on cognitive performance of CSD‐treated mice. Similarly, earlier reports had demonstrated that GE improved the hippocampal level of GSH and SOD and reduced the hippocampal level of MDA both in the scopolamine mouse model and LPS‐induced cognitive dysfunction in rat (Lu, Lv, Dong, et al, ; Mirahmadia et al, ). Additionally, the Nrf2, which is widely expressed in eukaryotic cells, had been confirmed to activate antioxidant defenses and was regarded as one of the most important mechanisms in cells for the protection against oxidative stress (Jiao et al, ; Lu, Wang, Lv, et al, ).…”

Section: Discussionsupporting

confidence: 60%

“…However, administration with GE recovered these impairments induced by CSD, suggesting the neuroprotective effects of GE on the recognition memory ability. Similarly, previous reports had also indicated the beneficial effects of GE on recognition memory that GE ameliorated the performance in the NOR test of the amyloid precursor protein/presenilin 1 double transgenic mouse model of Alzheimer's disease and lipopolysaccharide (LPS)-induced cognitive dysfunction of rats (Mirahmadia et al, 2018;Vicent et al, 2016). Furthermore, our previous study found that GE improved the cognitive performance of scopolamine-treated mice in the OLR test, which were similar to the present results (Lu, Wang, Lv, et al, 2018).…”

Section: Discussionmentioning

confidence: 74%

“…Meanwhile, GE administration markedly counteracted the oxidative (Lu, Lv, Dong, et al, 2018;Mirahmadia et al, 2018). Additionally, the Nrf2, which is widely expressed in eukaryotic cells, had been confirmed to activate antioxidant defenses and was regarded as one of the most important mechanisms in cells for the protection against oxidative stress (Jiao et al, 2018;Lu, Wang, Lv, et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation

Lü

Jiang

et al. 2020

Phytotherapy Research

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Sleep deprivation has been widely reported to cause cognitive dysfunction, and elevation in oxidative stress and inflammation in the body, including the brain, have been suggested as the main factors. Genistein (GE) is an isoflavone widely present in leguminous plants, and it was found to exert a wide spectrum of biological activities, including antioxidant, anti‐inflammatory, hepatoprotective, neuroprotective, and antimetastatic effects. In this study, the protective effect of GE on chronic sleep deprivation (CSD)‐induced cognitive dysfunction was investigated. The mice were subjected to the sleep interruption apparatus and continuously sleep deprived for 25 days. GE was orally administrated (10, 20, and 40 mg/kg) during the sleep deprivation process totally for 25 days. Cognitive behavioral tests were conducted to study the learning and memory using the object location recognition (OLR) task, novel object recognition (NOR) test, and the Morris water maze (MWM) task. Additionally, the cortex and hippocampus were dissected to measure the oxidative stress markers and the antioxidant element nuclear erythroid‐2‐related factor 2 (Nrf2) and its downstream targets, including glutamate cysteine ligase catalytic, glutamate cysteine ligase modifier, heme oxygenase 1, and quinone oxidoreductase 1, as well as nuclear factor kappa B (NF‐κB) p65, nitric oxide synthase (iNOS), and cyclooxygenase 2 (COX‐2) protein expression. Moreover, the pro‐inflammatory cytokines (TNF‐α, interleukin [IL]‐6, and IL‐1β) level was examined in the serum. The current results showed that GE could dose‐dependently ameliorate the cognitive deficits of CSD‐treated mice in the OLR, NOR, and MWM tasks. In addition, GE treatment significantly elevated the activities of total antioxidant capacity and superoxide dismutase and the level of glutathione and lowered the content of malondialdehyde in the cortex and hippocampus of CSD‐treated mice. Furthermore, GE administration effectively activated the antioxidant element Nrf2 and its downstream targets in the cortex and hippocampus of CSD‐treated mice. Moreover, GE treatment significantly suppressed CSD‐induced NF‐κB p65, iNOS, and COX‐2 activation in the cortex and hippocampus, as well as inhibited CSD‐induced pro‐inflammatory cytokines (TNF‐α, IL‐6, and IL‐1β) release in the serum. Taken together, all these results suggested that GE has substantial potential as a therapeutic intervention for the alleviation of CSD‐induced deleterious effects.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation

Lü

Jiang

et al. 2020

Phytotherapy Research

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“…30 Previous studies have investigated the role of genistein in brain injury and found that genistein has significant anti-inflammatory and anti-oxidative properties. [31][32][33] However, the poor water solubility of genistein restricted its wide use in the clinic.…”

Section: Discussionmentioning

confidence: 99%

Genistein‐3′‐sodium sulphonate protects against lipopolysaccharide‐induced lung vascular endothelial cell apoptosis and acute lung injury via BCL‐2 signalling

Lee

Chang

Zhao

et al. 2019

J Cellular Molecular Medi

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Under septic conditions, Lipopolysaccharide (LPS)‐induced apoptosis of lung vascular endothelial cells (ECs) triggers and aggravates acute lung injury (ALI), which so far has no effective therapeutic options. Genistein‐3′‐sodium sulphonate (GSS) is a derivative of native soy isoflavone, which has neuro‐protective effects through its anti‐apoptotic property. However, whether GSS protects against sepsis‐induced lung vascular endothelial cell apoptosis and ALI has not been determined. In this study, we found that LPS‐induced Myd88/NF‐κB/BCL‐2 signalling pathway activation and subsequent EC apoptosis were effectively down‐regulated by GSS in vitro. Furthermore, GSS not only reversed the sepsis‐induced BCL‐2 changes in expression in mouse lungs but also blocked sepsis‐associated lung vascular barrier disruption and ALI in vivo. Taken together, our results demonstrated that GSS might be a promising candidate for sepsis‐induced ALI via its regulating effects on Myd88/NF‐κB/BCL‐2 signalling in lung ECs.

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“…3,20 Recent advances suggest that dietary antioxidant decreased the MDA concentration and increased antioxidant status. 21,22 Our present study suggests that BSB and PSP combination not significantly decrease MDA concentration in DM rats. BSB contains isoflavones genistein and daidzein which acts as a scavenger to suppressing ROS production.…”

Section: Discussionmentioning

confidence: 49%

The Evaluation of Dietary Black Soybean and Purple Sweet Potato on Insulin Sensitivity in Streptozotocin - Induced Diabetic Rats

Gofur¹,

Witjoro²,

Ningtiyas³

et al. 2019

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Introduction: Hyperglycemia mediates the production of excess free radicals and reduces endogenous antioxidant in type 2 diabetes mellitus (T2DM). Black soybean (BSB) is rich in antioxidant mainly from isoflavones, whereas the antioxidant of purple sweet potato (PSP) comes from high anthocyanin. The study aimed to evaluate the efficacy of BSB, PSP, and its combination on malondialdehyde (MDA), superoxide dismutase (SOD) concentrations, insulin and insulin receptor substrate-1 (IRS-1) expression in T2DM rats. Methods: T2DM induced by high-calorie diet for five weeks and then injected with a low dose of streptozotocin (30 mg/kg BW) intraperitoneally. The DM rats then treated with black soybean (DM + BSB), purple sweet potato (DM + PSP) and the combination of BSB and PSP 1:3, 2:2, 3:1 respectively (DM + C1-3). Treatments were given for thirty days. The effect of BSB, PSP and its combination evaluated by measuring SOD and MDA, necrosis in pancreas evaluated through hematoxylin-eosin (HE) and insulin and IRS-1 expression in pancreas through immunohistochemistry-fluorescence (IHC-F). Results: Our result indicated that there were no significant differences of BSB and the combination in decreasing MDA concentrations. The ratio of BSB and PSP combination of 2:2 increase SOD towards near normal, decrease necrosis, and improve insulin and IRS-1. Conclusion: The combination of BSB and PSP had the potential to improve insulin sensitivity through the increase of SOD, reduce necrosis, and improve insulin and IRS-1 expression. and Natural Sciences, Brawijaya University, Indonesia. Her research interest field is nutrigenomic. Currently, she has a research projects about garlic and their impact for health.

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Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects

Cited by 79 publications

References 92 publications

Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation

Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation

Genistein‐3′‐sodium sulphonate protects against lipopolysaccharide‐induced lung vascular endothelial cell apoptosis and acute lung injury via BCL‐2 signalling

The Evaluation of Dietary Black Soybean and Purple Sweet Potato on Insulin Sensitivity in Streptozotocin - Induced Diabetic Rats

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