Soy isoflavonoid equol modulates the growth of benign and malignant prostatic epithelial cells in vitro

Hedlund, Tammy E.; Johannes, Widya U.; Miller, Gary J.

doi:10.1002/pros.10137

Cited by 120 publications

(104 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Polyphenols inhibited the growth of normal prostatic epithelial cells (Hedlund et al 2003), with inhibition of the IGF-I signal transduction pathway implicated in this activity , Wang S et al 2003. These findings provide further support for potential chemopreventive activity of polyphenols because IGF-I activity has been linked to increased prostate cancer risk (Pollak et al 2004).…”

Section: Chemopreventionmentioning

confidence: 73%

“…These findings provide further support for potential chemopreventive activity of polyphenols because IGF-I activity has been linked to increased prostate cancer risk (Pollak et al 2004). In many cases, the growth inhibitory concentrations of these compounds were within the range that can be attained through dietary consumption (Hedlund et al 2003). In contrast, prostate cancer cell lines show variable responses to polyphenols, and in many cases require supraphysiological concentrations for maximal effect (Hedlund et al 2003).…”

Section: Chemopreventionmentioning

confidence: 78%

“…In many cases, the growth inhibitory concentrations of these compounds were within the range that can be attained through dietary consumption (Hedlund et al 2003). In contrast, prostate cancer cell lines show variable responses to polyphenols, and in many cases require supraphysiological concentrations for maximal effect (Hedlund et al 2003).…”

Section: Chemopreventionmentioning

confidence: 99%

See 2 more Smart Citations

Primary cell cultures as models of prostate cancer development

Peehl¹

2005

Endocr Relat Cancer

152

142

View full text Add to dashboard Cite

This review focuses on primary cultures of human prostatic epithelial cells and their applications as models of normal and malignant biological behavior. Current abilities to culture cells from normal tissues, from premalignant dysplastic lesions (prostatic intraepithelial neoplasia), from primary adenocarcinomas, and from metastases are described. Evidence for representation of the interrelated cells of the normal prostatic epithelium -stem cells, basal epithelial cells, secretory epithelial cells, transit amplifying cells and neuroendocrine cells -in primary cultures is presented. Comparisons between normal and cancer-derived primary cultures are made regarding biological activities relevant to carcinogenesis, such as proliferation, apoptosis, differentiation, senescence, adhesion, migration, invasion, steroid hormone metabolism, other metabolic pathways and angiogenesis. Analyses of tumor suppressor activity, differential gene expression and cytogenetics in primary cultures have revealed changes relevant to prostate cancer progression. Preclinical studies with primary cultures have provided information useful for designing new strategies for chemoprevention, chemotherapy, cytotoxin therapy, radiation therapy, gene therapy and imaging. While the behavior of normal primary cultures is often used as a basis for comparison with established, immortal prostate cancer cell lines, the most informative studies are performed with donor-matched pairs of normal and malignant primary cultures, grown under identical conditions. Challenges that remain to be addressed if the full potential of primary cultures as a model system is to be realized include isolation, culture and characterization of stem cells, improved methodology to induce or maintain a fully differentiated, androgen-responsive phenotype, and identification of cell surface antigens or other markers with which to purify pure populations of live cancer or premalignant cells apart from non-malignant epithelial cells prior to culture.

show abstract

Section: Chemopreventionmentioning

confidence: 73%

Section: Chemopreventionmentioning

confidence: 78%

Section: Chemopreventionmentioning

confidence: 99%

See 1 more Smart Citation

Primary cell cultures as models of prostate cancer development

Peehl¹

2005

Endocr Relat Cancer

152

142

View full text Add to dashboard Cite

show abstract

“…Equol has been implicated with daidzein activities in vivo after ingestion of soy foods and has been shown to be more potent than daidzein in vitro (8,55,56). Equol is a chiral molecule capable of existing in two enantiomeric forms: R-(ϩ) equol and S-(Ϫ) equol; the latter is the natural diasteromer produced by intestinal bacteria (6,11).…”

Section: Discussionmentioning

confidence: 99%

The Soy Isoflavone Equol May Increase Cancer Malignancy via Up-regulation of Eukaryotic Protein Synthesis Initiation Factor eIF4G

Parra

Otero-Franqui

Martínez-Montemayor

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: The molecular mechanisms of soy isoflavones in metastatic cancer remain to be elucidated. Results: Equol, a daidzein metabolite, regulates eIF4G-mediated cap-independent protein synthesis initiation of proteins relevant for cancer malignancy. Conclusion: Equol is a potent regulator of the cancer promoting effects of dietary daidzein. Significance: Consumption of soy may not be advisable for patients with aggressive breast cancer.

show abstract

“…13,14 Additionally, equol can bind sex hormone-binding globulin 15,16 and 5a-dihydrotestosterone 14 and inhibit the growth of prostate cells in vitro and in vivo. 14,17 Therefore, equol can act as an anti-androgen and inhibit the development of sex hormone-dependent tumors such as breast cancer and prostate cancer. 14 In our previous study, we demonstrated that the proportion of equol producers was significantly smaller in the patient group with prostate cancer than in the cancer-free control group and that this proportion was significantly smaller in patients with poorly differentiated adenocarcinoma than in those with well or moderately differentiated adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Age-stratified serum levels of isoflavones and proportion of equol producers in Japanese and Korean healthy men

Fujimoto

Tanaka

Hirao

et al. 2008

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

Racial differences in the incidence of prostate cancer are manifest worldwide, possibly due to the different dietary habits. To elucidate the relationship between the recent trend of phytoestrogenic isoflavone intake and the increased incidence of prostate cancer in Japan, we conducted an agestratified dietary survey of soybean foods in 102 Japanese healthy men (age range: 10-59 years) and measured the serum isoflavones and equol levels in them and 100 Korean healthy men. The intergroup comparison among the age-stratified groups showed significant differences in the daily intake of genistein and daidzein between the teenager group and the other groups of age^30 years (Po0.05). In the Japanese study, the proportion of equol producers in the teenager group was 10%, being significantly the lowest among the age-stratified groups. The proportions of equol producers in the age-stratified groups from 10 to 49 years were also significantly lower than those in the fifties. The equol non-producers consumed significantly less amounts of isoflavones than the equol producers. In the Korean study, the proportions of equol producers were 45% in the teenager and 40% in the twenties and thirties, being significantly lower than in the forties (80%) and fifties (65%). The decreased intake of isoflavones, low serum level of equol and low incidence of equol production in the young generation may become potential risk factors for prostate cancer not only in Japan but also in Korea in the near future. Elucidating the mechanism of equol production may be promising in developing strategies for chemoprevention against prostate cancer.

show abstract

Soy isoflavonoid equol modulates the growth of benign and malignant prostatic epithelial cells in vitro

Abstract: Equol is a biologically active metabolite of daidzein that has potent antiproliferative effects on benign and malignant prostatic epithelial cells at concentrations that can be obtained naturally through dietary soy consumption.

Cited by 120 publications

References 62 publications

Primary cell cultures as models of prostate cancer development

Primary cell cultures as models of prostate cancer development

The Soy Isoflavone Equol May Increase Cancer Malignancy via Up-regulation of Eukaryotic Protein Synthesis Initiation Factor eIF4G

Age-stratified serum levels of isoflavones and proportion of equol producers in Japanese and Korean healthy men

Contact Info

Product

Resources

About