Soy Lecithin-Derived Liposomal Delivery Systems: Surface Modification and Current Applications

Abstract

The development of natural phospholipids for nanostructured drug delivery systems has attracted much attention in the past decades. Lecithin that was derived from naturally occurring in soybeans (SL) has introduced some auspicious accomplishments to the drug carrying aspect, like effectual encapsulation, controlled release, and successful delivery of the curative factors to intracellular regions in which they procure these properties from their flexible physicochemical and biophysical properties, such as large aqueous center and biocompatible lipid, self-assembly, tunable properties, and high loading capacity. Despite the almost perfect properties as a drug carrier, liposome is known to be quite quickly eliminated from the body systems. The surface modification of liposomes has been investigated in many studies to overcome this drawback. In this review, we intensively discussed the surface-modified liposomes that enhancing the targeting, cellular uptake, and therapeutic response. Moreover, the recent applications of soy lecithin-derived liposome, focusing on cancer treatment, brain targeting, and vaccinology, are also summarized.

Following the Fate of Dye-Containing Liposomes In Vitro

“…In general, cellular uptake of drug-containing nanocarriers, including liposomes, will determine both the efficacy of drug delivery and toxic effects of carrier-associated drugs or active molecules. Liposomes made of natural phospholipids offer reassuring safety profiles [4] and become one of the most studied nanomedicines. Their versatility offers opportunities to tailor their features to enhance specific interactions with the target site.…”

<p>ArtinM Grafted Phospholipid Nanoparticles for Enhancing Antibiotic Cellular Uptake Against Intracellular Infection</p>

“…The structure of phospholipid nanoparticles is similar to mammalian cell wall, hence served as a biocompatible, non-irritant, and biodegradable vehicle for cell permeation. 20,21 Having oligosaccharide binding on the cell surface, various proteins or protein domains called lectins have been applied as targeting agents for many drugs. 22,23 Lectin grafted nanoparticles are among emerging carriers for enhancing cellular uptake, ie, wheat germ agglutinin (WGA) and Ulex europaeus agglutinin I (UEA1).…”

“…The structure of phospholipid nanoparticles is similar to mammalian cell wall, hence served as a biocompatible, non-irritant, and biodegradable vehicle for cell permeation. 20 , 21 …”

“…57 Nanoparticle Internalization into the Cell Lecithin has been purposed for intracellular trafficking of various drugs. 20,21,41 For internalization study, a fluorochrome was employed to visualize the Rif-NP-AM using a confocal microscope following previous reports. [58][59][60] Balb/3T3 fibroblast cell selected in this study is among other cells used to evaluate intracellular S. aureus infection.…”

Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment

“…Analytical and in-depth research on the treatment of tumors has been carried out for a considerable length of time, for instance, chemotherapy which has been demonstrated to be viable has for several years received a significant amount of interest. However, the main limitation of the current clinical application of chemotherapy drugs is their respective wide bio-distribution and short half-life [8,9,10]. It is therefore critical to develop novel medicine delivery systems to overcome the underlying limitations and also improve the efficiency of the cancer treatment methods that are available.…”