Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat

Dietary supplementation with soy isoflavones or replacement with soy proteins prevents hepatic lipid droplet accumulation and alters expression of genes involved in lipid metabolism in rats

“…It has also been shown that intact dietary soy protein, but not an ISF-rich soy extract improved plasma lipids in ovariectomized cynomolgus monkeys (Greaves et al 1999). Additionally, 20 % SPI significantly reduced abdominal fat, liver TG and accumulation of lipid droplets in SD rats compared to 20 % casein diet containing the similar amount of genistein to the SPI diet (Simmen et al 2010). Our results are also supported by a study showing hypolipidemic effects of bconglycinin, one of the major soy storage proteins, in the hypercholesterolemic rats, which are comparable to the hypolipidemic drugs, fenofibrate and rosuvastatin (Ferreira et al 2012).…”

“…Feeding soy diets attenuated the formation and accumulation of liver lipid droplets and reduced TG content in both obese (Tovar et al 2005;Gudbrandsen et al 2006;Davis et al 2007) and non-obese rats (Simmen et al 2010). However, the molecular events involved in the hypolipidemic effects and NAFLD prevention of soy are different in obese and non-obese animals.…”

“…This led to the conclusion that soy proteins, but not isoflavones, reduced liver lipogenesis (Takahashi and Konishi 2011). Moreover, prevention of fat droplet formation and accumulation in the liver of non-obese rats fed soy diets was independent of genistein (Simmen et al 2010). On the other hand, isoflavones have been shown to regulate hepatic lipogenesis, insulin resistance or adiposity as well as adipocytokines involved in hepatic steatosis (Kim and Kang 2012).…”

The impact of male phytoestrogenization on the somato-sexual development and fertility of the offsprings in rats

“…Це відставання (на 14-15 %) спостерігалося й у 6-місячних щурів. Така затримка соматичного розвитку, можливо, викликана здатністю ФЕ гальмува-ти синтез білка [13], змінювати експресію генів білків у печінці, які регулюють мета-болізм жирних кислот і тиреоїдних гормонів [14]. Крім того, у тварин обох груп статеве дозрівання за часом опущення яєчок запіз-нювалося порівняно зі щурами контрольної групи: 24,0±0,3 щодо 22,6±0,4 доби (Р<0,01).…”

Nutritional and Bioactive Compounds of Soybean: Benefits on Human Health

“…The consumption of soy protein may also lead to low hepatic deposits of triglycerides (Ascencio et al, 2004), reducing the risk of hepatic lipotoxicity and therefore of steatosis (Tovar et al, 2005). In animals, soybean protein modulated the expression of genes that regulated lipid metabolism and thyroid hormone, promoting weight loss (Simmen et al, 2010). These mechanisms of action may attenuate metabolic changes that occur in obesity, which are related to insulin resistance (Oh et al, 2011).…”