Soy protein isolates of varying isoflavone content do not adversely affect semen quality in healthy young men

Beaton, Laura K.; McVeigh, Brianne L.; Dillingham, Barbara L.; Lampe, Johanna W.; Duncan, Alison

doi:10.1016/j.fertnstert.2009.08.055

Cited by 45 publications

(23 citation statements)

References 37 publications

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“…The lack of association we observed between urinary concentrations of phytoestrogens from male partners and TTP in this study may be due to the low in vitro affinity of individual phytoestrogens, which may make it more unlikely to exert a significant estrogenic activity among men. Moreover, effects of phytoestrogens on semen quality have been inconsistent, with studies typically only demonstrating effects on specific semenquality variables, if at all (10)(11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

“…Vegetable protein intake has also been shown to be associated with reduced ovulatory infertility (9), although phytoestrogen intake was not directly measured in this study. Studies in men have been conflicting, with some reports of effects on specific semen quality variables (10) or idiopathic male infertility (11), and others reporting no associations (12,13). However, to our knowledge, no previous studies have evaluated effects on couple fecundity as measured by time to pregnancy (TTP) 9 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Higher Urinary Lignan Concentrations in Women but Not Men Are Positively Associated with Shorter Time to Pregnancy

Mumford¹,

Sundaram²,

Schisterman³

et al. 2014

The Journal of Nutrition

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Phytoestrogens have been associated with subtle hormonal changes, although effects on fecundity are unknown. Our objective was to evaluate the association between male and female urinary phytoestrogen (isoflavone and lignan) concentrations and time to pregnancy (TTP) in a population-based cohort of 501 couples desiring pregnancy and discontinuing contraception. Couples were followed for 12 mo or until pregnancy. Fecundability ORs (FORs) and 95% CIs were estimated after adjusting for age, body mass index, race, site, creatinine, supplement use, and physical activity in relation to female, male, and joint couple concentrations. Models included the phytoestrogen of interest and the sum of the remaining individual phytoestrogens. FORs <1 denote a longer TTP and FORs >1 a shorter TTP. Urinary lignan concentrations were higher, on average, among female partners of couples who became pregnant during the study compared with women who did not become pregnant (median enterodiol: 118 vs. 80 nmol/L; P < 0.10; median enterolactone: 990 vs. 412 nmol/L; P < 0.05) and were associated with significantly shorter TTP in models based on both individual and couples' concentrations (couples' models: enterodiol FOR, 1.13; 95% CI: 1.02, 1.26; enterolactone FOR, 1.11; 95% CI: 1.01, 1.21). Male lignan concentrations were not associated with TTP, nor were isoflavone concentrations. Sensitivity analyses showed that associations observed are unlikely to be explained by potential unmeasured confounding by lifestyle or other nutrients. Our results suggest that female urinary lignan concentrations at levels characteristic of the U.S. population are associated with a shorter TTP among couples who are attempting to conceive, highlighting the importance of dietary influences on fecundity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Higher Urinary Lignan Concentrations in Women but Not Men Are Positively Associated with Shorter Time to Pregnancy

Mumford¹,

Sundaram²,

Schisterman³

et al. 2014

The Journal of Nutrition

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“…Deux études d'intervention viennent renforcer ces données d'observation, en montrant que la consommation d'isoflavones de soja n'a pas d'effet sur la santé reproductive masculine (Beaton, 2010 ;Mitchell, 2001). Selon le rapport de l'Afssa de 2005, des études menées chez l'animal suggéraient que la consommation d'isoflavones de soja pourrait augmenter le risque de récidive de cancer du sein.…”

Section: Sécurité Des Isoflavones Du Soja Au Cours Du Développementunclassified

Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé

Chevalier¹,

Debeuf²,

Joubrel³

et al. 2016

OCL

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Résumé -Aujourd'hui, 4 Français sur 10 consomment des aliments au soja. Les consommateurs les ont intégrés dans leur alimentation, sans bouleverser leurs habitudes alimentaires, parce qu'ils les considèrent naturels et sains. Les non consommateurs sont en attente de plus d'informations (origine géographique du soja et qualités nutritionnelles). La consommation est assez récente et devrait progresser dans les prochaines années. Les aliments élaborés à partir de la graine de soja fournissent des protéines de très bonne qualité nutritionnelle, des acides gras insaturés, des fibres, des vitamines et des minéraux. La graine de soja contient des isoflavones, dont une grande partie est éliminée lors de l'élaboration des aliments au soja (qui en contiennent 1 à 3 mg/g de protéine). La consommation actuelle d'aliments au soja est largement compatible avec l'apport maximal de 1mg/kg/j recommandé par l'Afssa en 2005. Le développement infantile avec les préparations à base de protéines de soja est comparable à celui observé avec celles à base de protéines de lait de vache ou avec le lait maternel, sur tous les paramètres étudiés (croissance, santé osseuse et fonctions métaboliques, reproductives, endocrines, immunitaires et neurologiques). Les aliments au soja semblent exercer un effet protecteur vis-à-vis du risque de cancer du sein (probablement lié aux isoflavones), surtout si la consommation est débutée avant l'adolescence. Chez les femmes ayant des antécédents de cancer du sein, l'alimentation peut intégrer les aliments au soja. Introduire des aliments à base de soja dans l'alimentation contribue aussi à maintenir la santé cardiovasculaire, du fait de leur effet favorable sur le taux de LDL-cholestérol, sur la fonction endothéliale, et potentiellement sur la tension artérielle. Mots clés :Alimentation / soja / consommation / nutrition / santé Abstract -Soyfoods: consumption in France, nutritional qualities and recent scientific data on its contribution to health. Today, 4 French people out of 10 eat soyfoods. Consumers have adopted them in their diet, without changing their habits, because they consider them natural and healthy. The non-users are waiting for more information (geographical origin, nutritional benefits). The consumption is relatively new and is expected to grow in the coming years. Soyfoods produced from soybeans provide high quality proteins, unsaturated fatty acids, fibres, vitamins and minerals. Soybeans contain isoflavones, much of which is lost during the production of soyfoods, which contain between 1 and 3 mg per g protein. The current consumption of soyfoods is largely consistent with the maximum intake of 1 mg/kg/day recommended by the Afssa in 2005. Infant development with formulas based on soy protein is similar to that observed with those based on cow milk or with breast milk, on all studied parameters (growth, bone health and metabolic, reproductive, endocrine, immune and neurological functions). Soyfoods may have a protective effect against the risk for breast cancer (probably due to isofla...

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“…Three clinical studies (89,151), one of which is available only as abstract (152) and one as case report (153), have examined the effects of isoflavone exposure on sperm and semen parameters. In contrast to the epidemiologic research by Chavarro et al (10), the intervention data show that isoflavone exposure does not lower sperm concentration.…”

Section: Sperm and Semen Effectsmentioning

confidence: 99%

“…In a second study conducted by researchers from the University of Guelph and the Fred Hutchinson Cancer Research Center in Seattle, 32 healthy young men consumed diets in random order that were supplemented with 32 g protein provided in the form of milk protein isolate, low-isoflavone ISP (approximately 1.6 mg/d isoflavones) or high-isoflavone ISP (approximately 62 mg/d isoflavones) for 57 d each, separated by 28-d washout periods (151). Analysis of semen samples collected on d 1 and 57 of each treatment period revealed no significant effects of diet on semen parameters including semen volume, sperm concentration, sperm count, total motile sperm count, sperm motility, and sperm morphology.…”

Section: Sperm and Semen Effectsmentioning

confidence: 99%

Soybean isoflavone exposure does not have feminizing effects on men: a critical examination of the clinical evidence

Messina

2010

Fertility and Sterility

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Soy protein isolates of varying isoflavone content do not adversely affect semen quality in healthy young men

Cited by 45 publications

References 37 publications

Higher Urinary Lignan Concentrations in Women but Not Men Are Positively Associated with Shorter Time to Pregnancy

Higher Urinary Lignan Concentrations in Women but Not Men Are Positively Associated with Shorter Time to Pregnancy

Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé

Soybean isoflavone exposure does not have feminizing effects on men: a critical examination of the clinical evidence

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