Soy sauce increased the oxidative stress tolerance of nematode via p38 MAPK pathway

Sugawara, Takaya; Saraprug, Danaporn; Sakamoto, Kazuichi

doi:10.1080/09168451.2018.1562873

Cited by 9 publications

(2 citation statements)

References 25 publications

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“…MAPKs have significant roles in mediating signals triggered by cytokines, growth factors, and environmental stress; and are involved in controlling cell proliferation, cell differentiation, and death [73,74]. Recently, it has been reported that soy sauce induced mitochromesis and increased oxidative stress tolerance, which is mediated through p38 MAPK pathway [75]. Development and progression of breast tumors involve a complex series of events, including oxidative stress, dysregulation of cellular differentiation, excessive proliferation and resistance to apoptosis [76].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Dimethylbenz[a]anthracene-Induced Breast Tumors in Rats by Soy Protein is Mediated by Downregulation of MAPK/AP-1 Signaling

Das¹

2022

JCRCT

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We reported earlier that replacement of casein by soy protein in the diets of rats exposed to the carcinogen, dimethylbenz[a]anthracene (DMBA), not only delayed the initiation of breast tumor but also had a protective effect against the development of aggressive tumor. The aim of this study was to elucidate the molecular mechanism by which soy protein offers these beneficial effects. Tumor was developed by gavage administration of single dose of 80 mg/kg of DMBA into 50-day old female rats, maintained on a standard AIN-76A diet containing either casein or soy protein. After ~120 days of DMBA administration, we evaluated the role of MAPK phosphorylation and subsequent AP-1 activation on the differential effects of soy protein and casein on the development of aggressiveness and progression of DMBA-induced breast tumor and determined if soy protein controls MMP-9 and uPAR expression by modifying AP-1 activity. The present study demonstrates that the beneficial effect of soy protein in breast tumor development is mediated by control of MAPK/AP-1 signaling. It is concluded that deactivation of MAPK pathway lead to down-regulation of the AP-1 activation which in turn down regulates the target gene and may be responsible for controlling breast tumor aggressiveness. Thus, it is suggested that MAPKs (ERK, p38 and JNK), MMP-9 and uPAR may be a potential target for anticancer therapy inhibiting tumor vasculature and invasion stimulated by tumor-associated stroma, and regulating the target gene and may be responsible for the beneficial effects of soy protein.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Dimethylbenz[a]anthracene-Induced Breast Tumors in Rats by Soy Protein is Mediated by Downregulation of MAPK/AP-1 Signaling

Das¹

2022

JCRCT

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“…Other than just a seasoning, soy sauce is also a potential functional food with anti-obesity and anti-hypertensive effects. In previous studies, soy sauce intake was found to alter the fat metabolism of Caenorhabditis elegans [18]. Traditional Korean soy sauce can ameliorate hypertension in rats [19].…”

Section: Introductionmentioning

confidence: 94%

Chinese Traditional Fermented Soy Sauce Exerts Protective Effects against High-Fat and High-Salt Diet-Induced Hypertension in Sprague-Dawley Rats by Improving Adipogenesis and Renin-Angiotensin-Aldosterone System Activity

et al. 2021

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Although high-fat and high-salt diets are considered risk factors for hypertension, the intake of salty soybean-based fermented foods has beneficial effects. This study explored the potential of Chinese traditional fermented soy sauce (CTFSS) in preventing hypertension by analyzing its effects on adipogenesis and the renin-angiotensin-aldosterone system (RAAS). Male Sprague-Dawley (SD) rats were divided into four groups (n = 6): normal diet (ND), high-fat diet (HD), high-fat diet with saline (HDS, NaCl-8%), and high-fat diet with Chinese traditional soy sauce (HDCTS, NaCl-8%). Each group is administrated 12 weeks by oral gavage as 10 mL/kg dose, respectively. CTFSS supplementation resulted in significantly lower body weight, epididymal fat weight, and systolic blood pressure. Additionally, it decreased the serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), renin, angiotensin II (Ang II), angiotensin-converting enzyme (ACE), and aldosterone levels. It also increased the urinary volume and improved sodium and potassium ion balance. The gene levels showed significant enhancements in the mRNA levels of renin-angiotensin-aldosterone system-related and adipogenesis-related genes. In addition, CTFSS may prevent hypertension-associated kidney injury. Therefore, this study demonstrates that CTFSS has no harmful effects on hypertension. In contrast, the beneficial effects of CTFSS intake in ameliorating hypertension were shown.

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The identification of soy sauce adulterated with bean species and the origin using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry

et al. 2023

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Soy sauce increased the oxidative stress tolerance of nematode via p38 MAPK pathway

Cited by 9 publications

References 25 publications

Inhibition of Dimethylbenz[a]anthracene-Induced Breast Tumors in Rats by Soy Protein is Mediated by Downregulation of MAPK/AP-1 Signaling

Inhibition of Dimethylbenz[a]anthracene-Induced Breast Tumors in Rats by Soy Protein is Mediated by Downregulation of MAPK/AP-1 Signaling

Chinese Traditional Fermented Soy Sauce Exerts Protective Effects against High-Fat and High-Salt Diet-Induced Hypertension in Sprague-Dawley Rats by Improving Adipogenesis and Renin-Angiotensin-Aldosterone System Activity

The identification of soy sauce adulterated with bean species and the origin using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry

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