Soyauxinine, a New Indolopyridoquinazoline Alkaloid from the Stem Bark of Araliopsis soyauxii Engl. (Rutaceae)

Noulala, Cédric Guy Tchatchouang; Ouete, Judith L. Nantchouang; Atangana, Albert Fouda; Bitchagno, Gabin Thierry M.; Fotso, Ghislain Wabo; Stammler, Hans‐Georg; Lenta, Bruno Ndjakou; Happi, Emmanuel Ngeufa; Sewald, Norbert; Ngadjui, Bonaventure T.

doi:10.3390/molecules27031104

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Treatment of CCRF-CEM cells with the compound at 3.64 μM IC 50 altered mitochondrial membrane potential and elevated ROS levels and apoptotic caspase protein expression in the leukemia cells. However, according to Noulala et al [ 61 ], soyauxinine showed poor antiproliferative effects on colon HT-29 and prostate PC-3 cancer cells.…”

Section: Anticancer Alkaloids From Plantsmentioning

confidence: 99%

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

2023

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Cancer is a neoplastic disease that remains a global challenge with a reported prevalence that is increasing annually. Though existing drugs can be applied as single or combined therapies for managing this pathology, their concomitant adverse effects in human applications have led to the need to continually screen natural products for effective and alternative anticancer bioactive principles. Alkaloids are chemical molecules that, due to their structural diversity, constitute a reserve for the discovery of lead compounds with interesting pharmacological activities. Several in vitro studies and a few in vivo findings have documented various cytotoxic and antiproliferative properties of alkaloids. This review describes chaetocochin J, neopapillarine, coclaurine, reflexin A, 3,10-dibromofascaplysin and neferine, which belong to different alkaloid classes with antineoplastic properties and have been identified recently from plants. Despite their low solubility and bioavailability, plant-derived alkaloids have viable prospects as sources of viable lead antitumor agents. This potential can be achieved if more research on these chemical compounds is directed toward investigating ways of improving their delivery in an active form close to target cells, preferably with no effect on neighboring normal tissues.

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Section: Anticancer Alkaloids From Plantsmentioning

confidence: 99%

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

2023

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“…As mentioned above, this tricyclic compound can inhibit HCV replication, but it is less potent than pseudane IX [ 21 ], and it contributes to the antifungal activity of the plant extract [ 19 ]. Arborinine can be isolated from diverse plants, including Rutaceae such as Vepris trichocarpa and Vepris teva [ 52 , 53 ], Araliopsis soyauxii [ 54 ] and different Ruta species [ 55 ]. Interestingly, the acridone alkaloid has been shown to exert marked antitumor activities.…”

Section: Bioactive Phytochemicals From R Angustifolia ...mentioning

confidence: 99%

Ruta angustifolia Pers. (Narrow-Leaved Fringed Rue): Pharmacological Properties and Phytochemical Profile

Bailly

2023

Plants

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The genus Ruta in the family Rutaceae includes about 40 species, such as the well-known plants R. graveolens L. (common rue) or R. chalepensis L. (fringed rue), but also much lesser-known species such as R. angustifolia Pers. (narrow-leaved fringed rue). This rue specie, originating from the Mediterranean region, is well-distributed in Southeast Asia, notably in the Indo-Chinese peninsula and other territories. In some countries, such as Malaysia, the plant is used to treat liver diseases and cancer. Extracts of R. angustifolia display antifungal, antiviral and antiparasitic effects. Diverse bioactive natural products have been isolated from the aerial parts of the plant, notably quinoline alkaloids and furocoumarins, which present noticeable anti-inflammatory, antioxidant and/or antiproliferative properties. The present review discusses the main pharmacological properties of the plant and its phytoconstituents, with a focus on the anticancer activities evidenced with diverse alkaloids and terpenoids isolated from the aerial parts of the plant. Quinoline alkaloids such as graveoline, kokusaginine, and arborinine have been characterized and their mode of action defined. Arborinine stands as a remarkable inhibitor of histone demethylase LSD1, endowed with promising anticancer activities. Other anticancer compounds, such as the furocoumarins chalepin and rutamarin, have revealed antitumor effects. Their mechanism of action is discussed together with that of other bioactive natural products, including angustifolin and moskachans. Altogether, R. angustifolia Pers. presents a rich phytochemical profile, fully consistent with the traditional use of the plant to treat cancer. This rue species, somewhat neglected, warrant further investigations as a medicinal plant and a source of inspiration for drug discovery and design.

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