Soybean-derived antihypertensive hydrolysates attenuate Ang II-induced renal damage by modulating MAPK and NF-κB signaling pathways

Song, Tianyuan; Ding, Yin-Yi; Zhang, Tiantian; Cai, Qiaolin; Hu, Yonghong; Gu, Qing; Gu, Zhenyu

doi:10.1039/d3fo05247h

Food Funct.

2024

DOI: 10.1039/d3fo05247h

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Soybean-derived antihypertensive hydrolysates attenuate Ang II-induced renal damage by modulating MAPK and NF-κB signaling pathways

Tianyuan Song,

Yin-Yi Ding,

Tiantian Zhang

et al.

Abstract: Hypertension-induced kidney injury is considered as a vital consequence of long-term and uncontrolled hypertension, and this process is commonly associated with excessive accumulation of angiotensin II (Ang II) from hyperactivated...

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Cited by 4 publications

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The Grifola frondosa-derived ACE inhibitory peptide attenuated the exosomes-mediated phenotype transformation of vascular smooth muscle cells

Song,

Zhang,

Cai

et al. 2024

Journal of Functional Foods

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The Grifola frondosa-derived ACE inhibitory peptide attenuated the exosomes-mediated phenotype transformation of vascular smooth muscle cells

Song,

Zhang,

Cai

et al. 2024

Journal of Functional Foods

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Risk assessment of di-(2-ethylhexyl) phthalate plus a high-fat diet in the rat kidney

Zhang,

Fan,

Yang

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Decoding the anti-hypertensive mechanism of α-mangostin based on network pharmacology, molecular docking and experimental validation

Xue,

Liu,

2024

Mol Med

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Background Hypertension is a leading risk factor for disability and deaths worldwide. Evidence indicates that alpha-mangostin(α-MG) can reduce blood pressure and improve target organ damage. Nonetheless, its pharmacological targets and potential mechanisms of action remain inadequately elucidated. Method We used SwissTargetPrediction to identify α-MG’s drug targets and DisGeNET, GeneCards, CTD, and GEO databases for hypertension-related targets, and then determined antihypertensive therapeutic targets of α-MG by intersecting these targets. GO functional enrichment analysis, KEGG pathway analysis, and disease association analysis were conducted using the DAVID database and R package “clusterprofile”, visualized with Cytoscape software. The binding affinity of α-MG to identified targets was confirmed through molecular docking using Autodock Vina v.1.2.2 software. The impact of α-MG on target genes was validated using an Angiotensin II-induced hypertensive mouse model and RT-qPCR. Results A total of 51 potential antihypertensive therapeutic targets for α-MG were identified by intersecting 109 drug targets with 821 disease targets. Furthermore, 10 cellular component terms, 10 disease terms, and the top 20 enriched biological processes, molecular functions, and KEGG pathways related to α-MG’s antihypertensive effects were documented. Molecular docking studies indicated a strong binding affinity of α-MG with the HSP90AA1 domain. In Ang II-induced hypertensive mice aorta, treatment with α-MG effectively reversed the aberrant mRNA expression of TNF, HSP90AA1, NFKB1, PPARG, SIRT1, PTGS2, and RELA. Conclusion Our analyses showed that TNF, HSP90AA1, NFKB1, PPARG, SIRT1, PTGS2, and RELA might be α-MG’s potential therapeutic targets for hypertension, laying groundwork for further investigation into its pharmacological mechanisms and clinical uses.

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Soybean-derived antihypertensive hydrolysates attenuate Ang II-induced renal damage by modulating MAPK and NF-κB signaling pathways

Abstract: Hypertension-induced kidney injury is considered as a vital consequence of long-term and uncontrolled hypertension, and this process is commonly associated with excessive accumulation of angiotensin II (Ang II) from hyperactivated...

Cited by 4 publications

References 50 publications

The Grifola frondosa-derived ACE inhibitory peptide attenuated the exosomes-mediated phenotype transformation of vascular smooth muscle cells

The Grifola frondosa-derived ACE inhibitory peptide attenuated the exosomes-mediated phenotype transformation of vascular smooth muscle cells

Risk assessment of di-(2-ethylhexyl) phthalate plus a high-fat diet in the rat kidney

Decoding the anti-hypertensive mechanism of α-mangostin based on network pharmacology, molecular docking and experimental validation

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