Soybean lectins and trypsin inhibitors, but not oligosaccharides or the interactions of factors, impact weight gain of rainbow trout (Oncorhynchus mykiss)

Hart, Steven D.; Bharadwaj, Anant S.; Brown, Paul B.

doi:10.1016/j.aquaculture.2010.03.027

Cited by 39 publications

(29 citation statements)

References 31 publications

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“…GOT, GPT, LDH and ALP are liver enzymes of fish and are useful tools for detecting problems of the liver (Campbell, ; Hart, Bharadwaj, & Brown, ). In the present study, the amount of GOT, ALP, LDH and GPT enzymes increased in conjunction with the added high doses (>2,500 g/kg) of carob syrup.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary carob (Ceratonia siliqua) syrup on blood parameters, gene expression responses and ammonia resistance in tilapia (Oreochromis niloticus)

Yılmaz

2020

Aquac Res

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In this study, carob (Ceratonia siliqua) syrup was supplemented in the diet of tilapia (Oreochromis niloticus), and its effects on growth performance, immunological and serum biochemical parameters, gene expression responses and ammonia resistance of the fish were investigated. Carob syrup was added to the fish diet in ratios of 0%, 5%, 2.5%, 1.25% and 0.625%, such that five different diets were prepared: control, Cerat5000, Cerat2500, Cerat1250 and Cerat625 respectively. The fish were fed with experimental diets for 60 days. The survival rate of fish fed with 5% carob syrup decreased compared with all other experimental groups. Thus, this study found that feeding tilapia fish with 1.25% carob syrup for 60 days increased gene expression responses, some innate immune parameters and ammonia resistance of the fish without negative effects on growth performance or serum biochemical variables.

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Section: Discussionmentioning

confidence: 99%

Effect of dietary carob (Ceratonia siliqua) syrup on blood parameters, gene expression responses and ammonia resistance in tilapia (Oreochromis niloticus)

Yılmaz

2020

Aquac Res

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“…The main anti-nutritional functions of SBA are inducing inflammation, destroying carcinogenic cells, influencing cell migration, signal transduction, proliferation, and division (Grant, 1989; Hart et al, 2010; Maxwell, 2011; Yau et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

The Integrins Involved in Soybean Agglutinin-Induced Cell Cycle Alterations in IPEC-J2

Pan¹,

Zhao²,

Yuan³

et al. 2017

Molecules and Cells

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Soybean agglutinin (SBA) is an anti-nutritional factor of soybean, affecting cell proliferation and inducing cytotoxicity. Integrins are transmembrane receptors, mediating a variety of cell biological processes. This research aims to study the effects of SBA on cell proliferation and cell cycle progression of the intestinal epithelial cell line from piglets (IPEC-J2), to identify the integrin subunits especially expressed in IPEC-J2s, and to analyze the functions of these integrins on IPEC-J2 cell cycle progression and SBA-induced IPEC-J2 cell cycle alteration. The results showed that SBA lowered cell proliferation rate as the cell cycle progression from G0/G1 to S phase (P < 0.05) was inhibited. Moreover, SBA lowered mRNA expression of cell cycle-related gene CDK4, Cyclin E and Cyclin D1 (P < 0.05). We successfully identified integrins α2, α3, α6, β1, and β4 in IPEC-J2s. These five subunits were crucial to maintain normal cell proliferation and cell cycle progression in IPEC-J2s. Restrain of either these five subunits by their inhibitors, lowered cell proliferation rate, and arrested the cells at G0/G1 phase of cell cycle (P < 0.05). Further analysis indicated that integrin α2, α6, and β1 were involved in the blocking of G0/G1 phase induced by SBA. In conclusion, these results suggested that SBA lowered the IPEC-J2 cell proliferation rate through the perturbation of cell cycle progression. Furthermore, integrins were important for IPEC-J2 cell cycle progression, and they were involved in the process of SBA-induced cell cycle progression alteration, which provide a basis for further revealing SBA anti-proliferation and anti-nutritional mechanism.

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“…Those authors postulated that this may be a reflection of the higher turnover rate of these amino acids relative to lysine. A similar effect may have been seen in a study undertaken by Hart et al (2010) who found significantly improved weight gain of juvenile yellow perch (Perca flavescens) fed a diet with an EAA profile reflecting that of the whole body profile of that species but supplied at a level 20% in excess of the reported Met requirement (i.e. the "ideal protein" relative to Met).…”

Section: Estimation Of Essential Amino Acid Requirementssupporting

confidence: 55%

Elucidation of the roles and requirements of sulphur amino acids in the diet of barramundi (Lates calcarifer)

Poppi¹

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With the increasing use of plant protein meals to replace fishmeal in aquafeeds, there is a concomitant need to properly characterise the requirements for individual amino acids in the diet of carnivorous fish species such as barramundi (Lates calcarifer). This may be especially important for methionine (Met) and taurine (Tau) which are known to be limiting in these ingredients. This project aimed to define the requirements for these nutrients for barramundi, as well as to elucidate some of the mechanisms underpinning any observed stimulatory effect on growth.The aim of the first experiment was to evaluate the methionine (Met) and total sulphur amino acid (TSAA) requirements of juvenile barramundi to act as a baseline for further study. A requirement for Met of between 10.5 (95% of maximum response) and 13.6g kg -1 (99% of maximum response) in a diet with 592g kg -1 CP and 6.6g kg -1 Cys (17.1-20.2g kg -1 TSAA; 1.8-2.3%CP Met + 1.1% CP Cys) was established. Additionally, it was concluded that at least 40% of concluded that taurine appears to be conditionally essential to barramundi.

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Soybean lectins and trypsin inhibitors, but not oligosaccharides or the interactions of factors, impact weight gain of rainbow trout (Oncorhynchus mykiss)

Cited by 39 publications

References 31 publications

Effect of dietary carob (Ceratonia siliqua) syrup on blood parameters, gene expression responses and ammonia resistance in tilapia (Oreochromis niloticus)

Effect of dietary carob (Ceratonia siliqua) syrup on blood parameters, gene expression responses and ammonia resistance in tilapia (Oreochromis niloticus)

The Integrins Involved in Soybean Agglutinin-Induced Cell Cycle Alterations in IPEC-J2

Elucidation of the roles and requirements of sulphur amino acids in the diet of barramundi (Lates calcarifer)

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