Soybean oil‐based polyurethane networks as candidate biomaterials: Synthesis and biocompatibility

Miao, Shida; Sun, Lina; Wang, Ping; Liu, Ruina; Su, Zhiguo; Zhang, Songping

doi:10.1002/ejlt.201200050

Cited by 94 publications

(62 citation statements)

References 43 publications

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“…The utilization of plant oils as feedstock for polymeric biomaterial synthesis is garnering greater attention2345. As an important renewable resource, plant oils have been utilized to synthesize various polymers including polyesters, polyolefins, and polyurethanes678.…”

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confidence: 99%

4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate

Miao

Zhu

Castro

et al. 2016

Sci Rep

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368

258

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Photocurable, biocompatible liquid resins are highly desired for 3D stereolithography based bioprinting. Here we solidified a novel renewable soybean oil epoxidized acrylate, using a 3D laser printing technique, into smart and highly biocompatible scaffolds capable of supporting growth of multipotent human bone marrow mesenchymal stem cells (hMSCs). Porous scaffolds were readily fabricated by simply adjusting the printer infill density; superficial structures of the polymerized soybean oil epoxidized acrylate were significantly affected by laser frequency and printing speed. Shape memory tests confirmed that the scaffold fixed a temporary shape at −18 °C and fully recovered its original shape at human body temperature (37 °C), which indicated the great potential for 4D printing applications. Cytotoxicity analysis proved that the printed scaffolds had significant higher hMSC adhesion and proliferation than traditional polyethylene glycol diacrylate (PEGDA), and had no statistical difference from poly lactic acid (PLA) and polycaprolactone (PCL). This research is believed to significantly advance the development of biomedical scaffolds with renewable plant oils and advanced 3D fabrication techniques.

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mentioning

confidence: 99%

4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate

Miao

Zhu

Castro

et al. 2016

Sci Rep

Self Cite

368

258

View full text Add to dashboard Cite

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“…The lactic acid‐incorporated polymer has an improved glass transition temperature, tensile strength, and biocompatible. According to Miao et al , the biocompatibility of polyurethane using a lactic acid initiator was tested in mice, and cell proliferation was confirmed on polyurethane. Polyurethane made from plant oil based 10‐Undecenoic acid is also known to be biocompatible .…”

Section: C3–c30 Oil Derivativesmentioning

confidence: 99%

Feasibility of unsaturated fatty acid feedstocks as green alternatives in bio‐oil refinery

Jeon

Han

Kim

et al. 2019

Biofuels Bioprod Bioref

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Bio‐oil contains plant, animal, fish, and micro‐algae oil, and more than 200 million tons are produced annually. However, many edible and non‐edible bio‐oils are still under development, and their value and feasibility have yet to be determined. The vast majority of bio‐oils produced in the world have a very high unsaturated fatty acid content (70–98%), which could be used as a renewable, eco‐friendly alternative to petroleum. Hydrolysis (or transesterification) with ethylene metathesis technology converts unsaturated fatty acids to C4–C30 oil fragments. These oil fragments are a sustainable chemical technology used in chemical industry platform technology and carbon dioxide abatement green chemical technology, and as a petrochemical substitute. These platform chemicals also have their own market but are used as raw materials for other products (polymers, surfactants, synthetic lubricants, plasticizers, other specialty chemicals, general purpose chemicals, biofuels, etc.). The biodegradability and biocompatibility of the polymeric materials made from the oil mean that it is also possible to develop diverse functional products with high added value such as toothpaste, dandruff treatment shampoo, and melanin pigment removal cosmetics, medical and shape memory polymer materials. According to the cradle‐to‐gate analysis for environmental impact and economics, the total carbon dioxide emission reduction per ton of soybean oil was estimated to be 1.5 kg kg−1 products. Moreover, the metathesis of soybean oil ($680/ton) with additional raw materials ($237.4) will generate a value that is 7.5 times higher at $6857. Due to the biodegradability and biocompatibility of the products made from bio‐oils, it is expected that various functional products with high added value will be developed and that industrial applicability will be greatly expanded in the near future. In addition, for the development of various derivatives, fusion and cooperative research in chemical fields such as catalytic engineering, organic chemistry, polymer chemistry, maintenance chemistry, and reaction engineering are essential. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd

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“…As already indicated for general implants, when the natural regeneration of damaged tissues is not viable a possible solution is to install an artificial scaffold in the damaged area to facilitate the regeneration process . Scaffolds help to ensure the agglomeration of cells into tissues, affecting their shape and mobility whilst also providing mechanical support . After fulfilling its purpose, the implant should undergo gradual degradation to be replaced by natural tissue without negatively impacting the human body…”

Section: Biodegradable and Biomedical Polymersmentioning

confidence: 99%

Recent developments in plant oil based functional materials

Mosiewicki

Aranguren

2015

Polymer International

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The increasing interest of academic and industrial sectors in the use of bio‐based materials mirrors the overwhelming need for replacing, as much as possible, petroleum derived chemicals, reducing the negative environmental impact derived from their usage. Vegetable oils fulfill this goal extremely well, because of their worldwide availability, large volume production at comparatively low prices and versatility of the modifications and reactions in which they can participate to produce a large variety of different monomers and polymer precursors. Further reactions of these chemicals can lead to very different types of final materials with varied applications. It is because of this remarkable versatility that many review articles have appeared during the last few years; many of them have dealt with the various routes for vegetable oil modification and options for polymer synthesis, whilst others were dedicated to the analysis of the properties of the derived materials, generally focusing on structural properties. In this review, we focus on the capabilities of vegetable oils to be modified and/or reacted to obtain materials with functional properties suitable for use in coatings, conductive or insulating materials, biomedical, shape memory, self‐healing and thermoreversible materials as well as other special functional applications. © 2015 Society of Chemical Industry

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Soybean oil‐based polyurethane networks as candidate biomaterials: Synthesis and biocompatibility

Cited by 94 publications

References 43 publications

4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate

4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate

Feasibility of unsaturated fatty acid feedstocks as green alternatives in bio‐oil refinery

Recent developments in plant oil based functional materials

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