Soybean protein lowers serum cholesterol levels in hamsters: Effect of debittered undigested fraction

Gatchalian-Yee, Marites; Arimura, Yoko; Ochiai, Eiko; Yamada, Koji; Sugano, Michihiro

doi:10.1016/s0899-9007(97)83005-5

Cited by 22 publications

(9 citation statements)

References 16 publications

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“…There are three characteristics of SBOS that are believed to be responsible for their hypocholesterolemic properties: (1) water solubility; (2) fermentability and (3) viscosity (Davidson and Maki, 1999), but the mechanism by which this occurred is not known. To this day, there are four hypotheses regarding the hypocholesterolemic effect of SBOS: (1) to accelerate the production of VFA, which enhances the excretion of cholesterol and bile acids (Tarasewicz et al, 2004;Terada et al, 1994) and decreases the production of endogenous cholesterol (Tortuero et al, 1997;Tarasewicz et al, 2004); (2) to increase the population of a group of available bacteria such as Bifidobacteria and Lactobacteria, which perhaps directly affects the activity of b-hydroxide-b-methylglutary-CoA reductase, accordingly restrains the synthesis of cholesterol and decreases the blood cholesterol content (Gilliland et al, 1985;Tasker and Potter, 1993); (3) to bind bile salts in the gut due to high viscosity, which increases the fecal steroid excretion, in particular as bile acids (Gatchalian-Yee et al, 1997;Moundras et al, 1997;Refstie et al, 1999); and (4) to activate the hepatic antioxidative defense system (Kim et al, 2005).…”

Section: Liver Histologymentioning

confidence: 99%

Effects of soybean oligosaccharides on lipid metabolism of Japanese flounder (Paralichthys olivaceus Temminck et Schlegel) fed animal or plant protein source-based diets

Deng

Mai

et al. 2007

Front. Agric. China

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A feeding trial was conducted to investigate the effects of dietary soybean oligosaccharides (SBOS) on the levels of cholesterol in plasma and liver, and the fatty acid composition in muscle and liver of juvenile Japanese flounder (Paralichthys olivaceus Temminck et Schlegel). Four isonitrogenous and isocaloric practical diets (crude protein 49%, gross energy 19 kJ/g) including only fish meal (FM) or soy protein isolate (SPI) as sole dietary protein source with (Diets FMO and SPIO) or without (Diets FM and SPI) supplemented SBOS (stachyose, 2.61%; raffinose, 0.61%) were formulated. Each diet was randomly assigned to triplicate aquaria stocked with 30 fish (initial body weight 1.93P0.02 g) each. Fish were maintained in the flow-through aquaria at water temperature ranging from 22.0°C to 25.0°C and fed twice (08:00, 16:00) daily to apparent satiation for 8 weeks. Dietary SBOS supplementation significantly increased the levels of total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) in plasma of the fish fed FM-based diets (P<0.05), but no significant differences were observed at the levels of plasma triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) and LDL-C/HDL-C ratio (P>0.05). The levels of TC, TG, HDL-C and LDL-C, and LDL-C/HDL-C ratio in plasma of the fish fed SPI-based diets were not significantly influenced by the supplemented SBOS (P>0.05). Supplementation of SBOS did not influence the hepatic TC, TG and lipid contents and lipid droplet accumulation in fish fed FM-based diets, but significantly decreased the hepatic TC, TG and lipid contents and lipid droplet accumulation in fish fed SPI-based diets (P<0.05). In contrast, supplemented SBOS significantly increased fecal cholesterol extraction in the fish fed FM-based diets (P<0.05), but no significant difference was observed in the fish fed SPI-based diets (P>0.05). The fatty acid composition in muscle and liver was not significantly affected by supplemental SBOS regardless of dietary protein source (P>0.05). These results indicate that dietary SBOS supplementation (stachyose, 2.61%; raffinose, 0.61%) does not negatively affect the lipid metabolism of the fish fed FM-based diets, but decrease the incidences of fatty liver of the fish fed SPI-based diets.Effects of soybean oligosaccharides on lipid metabolism of Japanese flounder (Paralichthys olivaceus Temminck et Schlegel) fed animal or plant protein source-based diets

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Section: Liver Histologymentioning

confidence: 99%

Effects of soybean oligosaccharides on lipid metabolism of Japanese flounder (Paralichthys olivaceus Temminck et Schlegel) fed animal or plant protein source-based diets

Deng

Mai

et al. 2007

Front. Agric. China

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“…A number of studies have demonstrated that the PF of soya protein hydrolysate is more hypocholesterolaemic than soya protein itself (Sugano et al 1990;Gatchalian-Yee et al 1997), and SF from soya protein hydrolysate had no hypocholesterolaemic effect in rats fed a cholesterol-enriched diet (Sugano et al 1988). In the present study, SF had a greater cholesterol-lowing effect than PF, which may have been due to the different animal model we used.…”

Section: Discussionmentioning

confidence: 46%

“…X, Casein group (nephrectomized rats with 180 g casein/kg); W, ISP group (nephrectomized rats with 180 g isolated soya protein/kg); O, SF group (nephrectomized rats with 100 g casein and 80 g supernatant fraction of soya protein hydrolysate/kg); K, PF group (nephrectomized rats with 100 g casein and 80 g precipitate fraction of soya protein hydrolysate/kg); B, sCasein group (sham-operated rats with 180 g casein/kg); A, sISP group (sham-operated rats with 180 g isolated soya protein/kg). the major mechanism for the hypocholesterolaemic effect of PF (Sugano et al 1988;Gatchalian-Yee et al 1997;. The results of the present study showed that the faecal cholesterol and bile acid excretion increased significantly in the PF group compared with the SF group; thus, another mechanism must be responsible for the cholesterollowering effect of SF.…”

Section: Discussionmentioning

confidence: 49%

“…The constituents of soya protein that possess renal protective effects remain to be identified. Research has shown that the hydrophobic precipitate fraction (PF) of soya protein hydrolysate has a hypocholesterolaemic effect (Sugano et al 1990;Gatchalian-Yee et al 1997), and that the hydrophilic supernatant fraction (SF) can attenuate the development of hypertension in spontaneously hypertensive rats (Yang et al 2004). The objectives of this study were to investigate the effect of the two fractions of soya protein hydrolysate on renal function, blood pressure and lipid metabolism in rats with chronic renal failure induced by a five-sixths nephrectomy, and to examine the active components of soya protein hydrolysate on ameliorating disease progression.…”

mentioning

confidence: 99%

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Effects of various soya protein hydrolysates on lipid profile, blood pressure and renal function in five-sixths nephrectomized rats

Chen,

Yang,

Huang

et al. 2006

Br J Nutr

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Studies have demonstrated that isolated soya protein (ISP) can slow the progression of renal injury, reduce blood pressure and improve the serum lipid profile in experimental animals and human subjects. The mechanisms and components of soya responsible have not been fully established. The present study was designed to evaluate the effects of the hydrophilic supernatant fraction (SF) and the hydrophobic precipitate fraction (PF) isolated from soya protein hydrolysate on renal function, lipid metabolism and blood pressure in five-sixths nephrectomized rats. Experimental animals were subjected to a nephrectomy and allocated to four groups (180g casei/g, 180g IS/g, 100g casei/g with 80g S/g, and 100g casei/g with 80g P/g). The SF group had the most significant decreases in blood pressure and total cholesterol, as well as a significantly retarded progression of the experimentally induced renal disease, compared with the other groups. The PF group exhibited a significantly increased faecal excretion of total steroids. The serum creatinine, level of proteinuria, total cholesterol and LDL-cholesterol concentrations, and blood pressure were significantly reduced, and HDL-cholesterol was significantly increased, in the ISP and PF groups compared with the casein group, but no significant differences were observed between the ISP and PF groups. These results suggest that both soya protein hydrolysate fractions favourably affected chronic renal failure induced by a five-sixths nephrectomy, and the hydrophilic fraction of soya protein hydrolysate had the most pronounced effect on attenuating hypertension and slowing the progression of renal disease.

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“…Atendo-se a valores absolutos, poderíamos concluir que o teor de HDL-Colesterol dos animais alimentados com dieta amaranto foi inferior ao dos animais alimentados com dieta hipercolesterolemizante, quando na verdade, o colesterol estava sendo carreado em mais de 55% pela HDL na dieta AM, e em 46% na dieta hiper. GATCHALIAN-YEE et al (1997) embora também tenham notado uma diminuição do HDLcolesterol quando a concentração de colesterol total foi diminuída, relata que não houve diferença significativa na relação HDL-C/colesterol total, no entanto neste estudo todas as dietas continham proteína de soja, inclusive o controle.…”

Section: Perfil Lipídicounclassified

Efeito Hipocolesterolemizante da Proteína de Amaranto (Amaranthus cruentus BRS-Alegria) em Hamsters

Mendonça¹

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pela confiança plena que teve em meu potencial e pela imensa contribuição ao meu desenvolvimento intelectual. À FAPESP (Fundação de Amparo a Pesquisa do Estado de São Paulo), pela bolsa de estudo concedida. Ao Prof. Dr. Paulo H. Saldiva que possibilitou a realização do experimento biológico, contribuindo com pessoal técnico, lâminas histológicas, trâmites burocráticos junto ao Hospital das Clínicas e Comitê de Ética. Estendendo o agradecimento, em especial, à Dra. Heloísa, por sua participação na obtenção, coletas e sacrifício dos animais. Ao Prof. Dr. Carlos E. Corbett por colocar a disposição seu biotério para realização do experimento animal. Ao biólogo Robison Cruz, por seu trabalho de coleta e sacrifício dos animais, e por sua contribuição na execução de um projeto dentro dos parâmetros éticos. Às professoras Elisabeth Torres e Deborah Bastos pelas orientações, e por disponibilizar o uso de equipamentos de laboratório. À Dra. Patrícia Sinnecker, por suas preciosas orientações, amizade e carinho. A Jefferson Monteiro Gonçalves, pelo apoio fundamental no início do doutorado.

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Soybean protein lowers serum cholesterol levels in hamsters: Effect of debittered undigested fraction

Cited by 22 publications

References 16 publications

Effects of soybean oligosaccharides on lipid metabolism of Japanese flounder (Paralichthys olivaceus Temminck et Schlegel) fed animal or plant protein source-based diets

Effects of soybean oligosaccharides on lipid metabolism of Japanese flounder (Paralichthys olivaceus Temminck et Schlegel) fed animal or plant protein source-based diets

Effects of various soya protein hydrolysates on lipid profile, blood pressure and renal function in five-sixths nephrectomized rats

Efeito Hipocolesterolemizante da Proteína de Amaranto (Amaranthus cruentus BRS-Alegria) em Hamsters

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