The persistence of inoculants from year to year in soybean [Glycine max (L.) Merr.] cultivation and the residual benefits in soybean production are pertinent to adopting such practices in sub-Saharan Africa countries such as Ghana. A study was conducted to determine the residual effect of commercial rhizobium inoculants on soybean and selected soil health parameters after three cropping seasons. The experimental design was a split-plot. The main plot consisted of three soybean cultivars (Jenguma, Afayak, and Songda), and the subplot comprised of three peat-based commercial bradyrhizobium inoculants (Biofix, Legumefix, and NoduMax) and an uninoculated control. Assessments were made on nodulation, shoot dry matter (DM), grain yield, grain total N uptake, permanganate-oxidizable carbon (POXC), soil pH, and potentially mineralizable C. Among the soybean cultivars, Afayak produced greater nodule mass on the lateral root and the whole root system compared with the other cultivars. Jenguma and Afayak yielded greater shoot DM relative to Songda. Regarding the inoculants, Biofix increased nodule mass on the lateral root and the whole root system compared with the control. Biofix and NoduMax produced superior grain yield relative to the control. Biofix also produced greater grain yield than Legumefix. A superior pod harvest index and an improved grain total N uptake were produced by Biofix compared with Legumefix and the control. Commercial inoculants enhanced POXC availability at harvest, whereas potentially mineralizable C declined with inoculation treatments.Commercial inoculants (Biofix and NoduMax) enhanced nodulation, grain yield, and selected soil health indicators 3 yr after inoculation.