SP-0489: HPV-transformation in the cervix and at non-cervical sites

Validation of EUROArray HPV test using the VALGENT framework

“…The EUROArray HPV is a PCR based test with a probe-based microarray detection platform which is able to simultaneously detect E6 and E7 gene regions of 30 different anogenital HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68; 26, 53, 66, 70, 73, 82; 6, 11, 40, 42, 43, 44, 54, 61, 72, 81, 89. The first 13 genotypes (hrHPV types) of this list are causally associated with the development of cervical cancer [14], six are "possible" hrHPV types [15,16], whereas the remainder are low-risk HPVs or types of unknown carcinogenicity. Here, we present assessment of the performance for the hrHPV testing of the EUROArray HPV test relative to the HC2 in terms of sensitivity and specificity for CIN2+ in addition to intra-and inter-laboratory reproducibility.…”