Sp1-activated FGFR2 is involved in early-life exposure to nickel-induced craniosynostosis by regulating the ERK1/2 signaling pathway

Weng, Zhenkun; Xu, Cheng; Chen, Xiu; Yan, Qing; Fu, Zuqiang; Jiao, Jian; Xu, Jin; Liu, Qian; Wang, Dongmei; Liang, Jingjia; Li, Wenxiang; Gu, Aihua

doi:10.1016/j.envint.2024.108477

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The Role Of Dna Methylation In the Osteogenic Differentiatio...1

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2024

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“…This leads to the activation of FGFR2, which plays a vital role in regulating ERK1/2 signaling. Consequently, osteogenic differentiation of hMSCs is promoted through ERK1/2 signaling, which results in cranial suture fusion ( Weng et al, 2024 ).…”

Section: The Role Of Dna Methylation In the Osteogenic Differentiatio...mentioning

confidence: 99%

Effect of DNA methylation on the osteogenic differentiation of mesenchymal stem cells: concise review

Lai,

Shu,

Song

et al. 2024

Front. Genet.

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Mesenchymal stem cells (MSCs) have promising potential for bone tissue engineering in bone healing and regeneration. They are regarded as such due to their capacity for self-renewal, multiple differentiation, and their ability to modulate the immune response. However, changes in the molecular pathways and transcription factors of MSCs in osteogenesis can lead to bone defects and metabolic bone diseases. DNA methylation is an epigenetic process that plays an important role in the osteogenic differentiation of MSCs by regulating gene expression. An increasing number of studies have demonstrated the significance of DNA methyltransferases (DNMTs), Ten-eleven translocation family proteins (TETs), and MSCs signaling pathways about osteogenic differentiation in MSCs. This review focuses on the progress of research in these areas.

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Section: The Role Of Dna Methylation In the Osteogenic Differentiatio...mentioning

confidence: 99%

Effect of DNA methylation on the osteogenic differentiation of mesenchymal stem cells: concise review

Lai,

Shu,

Song

et al. 2024

Front. Genet.

View full text Add to dashboard Cite

show abstract

Sp1-activated FGFR2 is involved in early-life exposure to nickel-induced craniosynostosis by regulating the ERK1/2 signaling pathway

Cited by 1 publication

References 54 publications

Effect of DNA methylation on the osteogenic differentiation of mesenchymal stem cells: concise review

Effect of DNA methylation on the osteogenic differentiation of mesenchymal stem cells: concise review

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