Sp292effect of Very Low-Protein Diet Versus Standard Low-Protein Diet on Renal Death in Patients With Chronic Kidney Disease: A Pragmatic, Randomized, Controlled, Multicenter Trial

Bellizzi, Vincenzo; Signoriello, Simona; Minutolo, Roberto; Iorio, Biagio Di; Nazzaro, Paola; Conte, Giuseppe; Chiodini, Paolo; Nicola, Luca De

doi:10.1093/ndt/gfv191.12

Cited by 3 publications

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“… 30 On the other hand, the prescription of an sVLPD to unselected CKD patients does not reduce the risk of renal death in the whole population, mainly due to low diet adherence but also to age, diabetes, cardiovascular comorbidities and the previous GFR low decline rate. 31 Therefore, the sVLPD is effective in reducing the decline rate of GFR and deferring dialysis initiation but the selection of subjects and the high adherence to the diet are mandatory. 30 A further key-point is the continuous nutritional counseling to maintain the high adherence.…”

Section: Practical Application Of the Very Low-protein Diet In Chronimentioning

confidence: 99%

“…Recent advances in clinical research definitely demonstrated that the ketodiet is highly effective in reducing the renal death in selected, well‐nourished, progressive CKD, proven diet adherent, low‐comorbidity patients 30 . On the other hand, the prescription of an sVLPD to unselected CKD patients does not reduce the risk of renal death in the whole population, mainly due to low diet adherence but also to age, diabetes, cardiovascular comorbidities and the previous GFR low decline rate 31 . Therefore, the sVLPD is effective in reducing the decline rate of GFR and deferring dialysis initiation but the selection of subjects and the high adherence to the diet are mandatory 30 .…”

Section: Practical Application Of the Very Low‐protein Diet In Chroni...mentioning

confidence: 99%

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Very low‐protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease

Bellizzi

Calella

Carrero

et al. 2018

Chronic Diseases and Translational Medicine

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The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate to advanced renal failure, the dietary manipulation of nutrients improves metabolic abnormalities and may contribute to delay the time of dialysis initiation. This commentary focuses on the physiopathological rationale and the clinical application of the very low-protein diet supplemented with ketoanalogs for the management of chronic kidney disease.

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Section: Practical Application Of the Very Low-protein Diet In Chronimentioning

confidence: 99%

Section: Practical Application Of the Very Low‐protein Diet In Chroni...mentioning

confidence: 99%

Very low‐protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease

Bellizzi

Calella

Carrero

et al. 2018

Chronic Diseases and Translational Medicine

Self Cite

View full text Add to dashboard Cite

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Low protein diets for non-diabetic adults with chronic kidney disease

Hahn

Hodson

Fouque

2018

Cochrane Database of Systematic Reviews

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Background Chronic kidney disease (CKD) is defined as reduced function of the kidneys present for 3 months or longer with adverse implications for health and survival. For several decades low protein diets have been proposed for participants with CKD with the aim of slowing the progression to end-stage kidney disease (ESKD) and delaying the onset of renal replacement therapy. However the relative benefits and harms of dietary protein restriction for preventing progression of CKD have not been resolved. This is an update of a systematic review first published in 2000 and updated in 2006 and 2009. Objectives To determine the e icacy of low protein diets in preventing the natural progression of CKD towards ESKD and in delaying the need for commencing dialysis treatment in non-diabetic adults. Search methods We searched the Cochrane Kidney and Transplant Register of Studies up to 2 March 2018 through contact with the Information Specialist using search terms relevant to this review. Studies in the Register are identified through searches of CENTRAL, MEDLINE, and EMBASE, conference proceedings, the International Clinical Trials Register (ICTRP) Search Portal and ClinicalTrials.gov. Selection criteria We included randomised controlled trials (RCTs) or quasi RCTs in which adults with non-diabetic chronic kidney disease (stages 3 to 5) not on dialysis were randomised to receive a very low protein intake (0.3 to 0.4 g/kg/d) compared with a low protein intake (0.5 to 0.6 g/kg/d) or a low protein intake compared with a normal protein intake (≥ 0.8 g/kg/d) for 12 months or more. Data collection and analysis Two authors independently selected studies and extracted data. For dichotomous outcomes (death, all causes), requirement for dialysis, adverse e ects) the risk ratios (RR) with 95% confidence intervals (CI) were calculated and summary statistics estimated using the random e ects model. Where continuous scales of measurement were used (glomerular filtration rate (GFR), weight), these data were analysed as the mean di erence (MD) or standardised mean di erence (SMD) if di erent scales had been used. The certainty of the evidence was assessed using GRADE.

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