Sp322renal Function Evolution in Patients With Hepatitis C Virus (Hcv) With Baseline Estimated Glomerular Filtration Rate (Egfr) Between 30-60 Ml/Min/1,73 M2 Treated With Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir (3d) vs. Regimens Based on Sofosbuvir (Sof)

KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease

“…Most of the studies that examined this issue were conducted in patients with moderate CKD. Gonzalez-Parra and colleagues 110 observed a significant mean decrease in GFR of 9 ml/min per 1.73 m 2 in 35 patients treated with a sofosbuvirbased regimen with a baseline GFR of 30 to 60 ml/min per 1.73 m 2 , whereas no significant decline in GFR occurred in 8 patients treated with the PrOD regimen. Rosenblatt et al 111 also reported that in a series of 90 patients, a baseline CrCl < 60 ml/min predicted a decline in kidney function with sofosbuvir therapy.…”