Sp550effect of Comet Score on Survival Among Chronic Hemodialysis Patients in Okinawa, Japan

Nishihira, Morikuni; Taira, Shogo; Tamayose, Shiori; Adachi, Takayuki; Terukina, Shigetomo; Kikumura, Tasuku; Nagayama, Kiyomitsu; Oroku, Masato; Shimoji, Kunihiro; Tokuyama, Kiyoyuki; Shiohira, Yoshiki; Iseki, Kunitoshi

doi:10.1093/ndt/gfy104.sp550

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“…This study utilized these parameters, where tail length and tail moment may be computed differently in other visual analysis systems. The percentage of DNA in the tail seems to be the proper parameter for comparing DNA damage between laboratories [14].…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of the protective effect of simvastatin on genotoxic effects of doxorubicin via comet assay

Nikzad¹,

Shokrzadeh

2022

ijhs

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Background and purpose: Doxorubicin (Adriamycin) a chemotherapeutic agent belonging to Anthracycline family, is frequently used in the treatment of cancers. Despite its effectiveness, a vast variety of adverse effects have been attributed to this drug with the suggested mechanisms of inducing ROS and mitochondrial damage causing hepatic and cardiac toxicity. In addition to cancer cells, doxorubicin also interferes with the normal cell genome and consequently induce secondary malignancy. Simvastatin, Simvastatin is a fat-lowering drug that has cytoprotective and antioxidant effects. This study attempts to examine the protective effect of simvastatin against doxorubicin induced genotoxicity in the culture medium using the Comte method. Materials and Methods: For this purpose, we measured the DNA damage level with comet assay in HepG2 and HGF cells treated with doxorubicin and simvastatin in pre-treatment condition. Results were reported based on mean ± SEM. p<0.05 considered as significant deference. The mean values were compared using SPSS and ANOVA test followed by tukey posttest.

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Section: Methodsmentioning

confidence: 99%

“…Comet assay data were analyzed, and the diagram of the parameters was drawn in Prism 3 graphic software. One-way ANOVA and posthoc Tukey's multiple comparison test were employed at the 0.05 significance level [14].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the protective effect of simvastatin on genotoxic effects of doxorubicin via comet assay

Nikzad¹,

Shokrzadeh

2022

ijhs

View full text Add to dashboard Cite

show abstract

Sp550effect of Comet Score on Survival Among Chronic Hemodialysis Patients in Okinawa, Japan

Cited by 1 publication

References 0 publications

Evaluation of the protective effect of simvastatin on genotoxic effects of doxorubicin via comet assay

Evaluation of the protective effect of simvastatin on genotoxic effects of doxorubicin via comet assay

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