Space and Bond Synergistic Conjugation Controlling Multiple‐Aniline NIR‐II Absorption for Photoacoustic Imaging Guided Photothermal Therapy

Liu, Longcai; Pan, Yi; Ye, Luyi; Zhang, Tian; Yang, Chen; Chen, Liang; Chen, Dapeng; Mou, Xiaozhou; Dong, Xiaochen; Cai, Yu

doi:10.1002/adhm.202301116

Cited by 6 publications

(1 citation statement)

References 61 publications

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“…1 d, the temperature increased sharply along with the increasing concentration of PYT NPs, especially after 5 min laser irradiation, the temperature of PYT NPs (50 μg mL −1 ) showed an increase from 26.1 to 69.1 °C. The sharp increase in temperature with increasing concentration in a photothermal effect may be attributed to the greater absorption of photons and more efficient energy transfer within the material [ 29 , 30 ]. The temperature changes of PYT NPs (50 μg mL −1 ) also were recorded under 808 nm laser irradiation with different laser powers (0.1, 0.4, 0.7, 1.0 W cm −2 ), the temperature of PYT NPs were increased to 28.6, 38.9, 48.7, 69.1 °C, respectively (Additional file 1 : Fig.…”

Section: Resultsmentioning

confidence: 99%

A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy

Xie,

Wang,

Zeng

et al. 2023

J Nanobiotechnol

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Photothermal therapy (PTT) and photodynamic therapy (PDT) are effective method for tumor treatment. However, the limited variety and quantity of photothermal agents (PTAs) and photosensitizer (PSs) are still major challenges. Moreover, the cell apoptosis mechanism induced by PDT and PTT is still elusive. A fused-ring small molecule acceptor–donor acceptor′ donor–acceptor (A-DA′D-A) type of Y5 (Scheme 1) has a narrow band-gap and strong light absorption. Herein, we used Y5 to polymerize with thiophene unit to obtain polymer PYT based on polymerized small molecule strategy, and PYT nanoparticles (PYT NPs) was prepared via one-step nanoprecipitation strategy with DSPE-PEG2000. PYT NPs had excellent biocompatibility, good photostability, high photothermal conversion efficiency (67%) and reactive oxygen species (ROS) production capacity under 808 nm laser irradiation (PYT NPs + NIR). In vitro and in vivo experiments revealed that PYT NPs + NIR had the ability to completely ablate tumor cells. It was demonstrated that cell apoptosis induced by PYT NPs + NIR was closely related to mitochondrial damage. This study provides valuable guidance for constructing high-performance organic PTAs and PSs for tumor treatment.

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Section: Resultsmentioning

confidence: 99%

A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy

Xie,

Wang,

Zeng

et al. 2023

J Nanobiotechnol

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Transforming Commercial Polymers into Tough yet Switchable Adhesives by Trident Photoswitch Molecule Doping: Break Adhesion‐Switchability Paradox

Lin,

Feng,

Fang

et al. 2024

Advanced Materials

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Here, a trident molecule doping strategy is introduced to overcome both cohesion‐adhesion trade‐off and adhesion‐switchability conflict, transforming commercial polymers into tough yet photo‐switchable adhesives. The strategy involves initial rational design of new trident photoswitch molecules namely TAzo‐3 featuring azobenzene and hydroxy‐terminated alkyl chains involved rigid‐soft tri‐branch structure, and subsequent doping into commercial polycaprolactone (PCL) via simple blending. Unique design enables TAzo‐3 as a versatile dopant, not only regulating the internal and external supramolecular interaction to balance cohesion and interface adhesion for tough bonding, but also affording marked photothermal effect to facilitate rapid adhesive melting for great photo‐switchability. Thus, the optimal TAzo‐3‐doped PCL (TAzo‐3@P) displays markedly‐improved bonding performance on diverse substrates compared to linear azobenzene‐doped PCL and pure PCL. Impressively, TAzo‐3@P on polymethyl methacrylate (PMMA) attains large room‐temperature adhesion strength of 6.7 MPa – surpassing most reported adhesives and many commercial adhesives on PMMA, along with easy photo‐induced detachment with remarkable switch ratio of 2.09 × 105. Besides, TAzo‐3@P can also act as “permanent” adhesives for only adhesion, demonstrating excellent multi‐reusability, anti‐freezing and waterproof ability. Mechanism studies unveil that the switchable adhesion is closely linked with the dopant molecule structure while rigid‐soft coupled trident structures and hydroxy‐terminated alkyl chains are key factors.

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NIR‐II Absorbed Dithienopyrrole‐Benzobisthiadiazole Based Nanosystems for Autophagy Inhibition and Calcium Overload Enhanced Photothermal Therapy

Liu,

Chen,

et al. 2024

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Although the current cancer photothermal therapy (PTT) can produce a powerful therapeutic effect, tumor cells have been proved a protective mechanism through autophagy. In this study, a novel hybrid theranostic nanoparticle (CaCO3@CQ@pDB NPs, CCD NPs) is designed and prepared by integrating a second near‐infrared (NIR‐II) absorbed conjugated polymer DTP‐BBT (pDB), CaCO3, and autophagy inhibitor (chloroquine, CQ) into one nanosystem. The conjugated polymer pDB with asymmetric donor–acceptor structure shows strong NIR‐II absorbing capacity, of which the optical properties and photothermal generation mechanism of pDB are systematically analyzed via molecular theoretical calculation. Under NIR‐II laser irradiation, pDB‐mediated PTT can produce powerful killing ability to tumor cells. At the same time, heat stimulates a large amount of Ca2+ inflow, causing calcium overload induced mitochondrial damage and enhancing the apoptosis of tumor cells. Besides, the released CQ blocks the self‐protection mechanism of tumor cells and greatly enhances the attack of PTT and calcium overload therapy. Both in vitro and in vivo experiments confirm that CCD NPs possess excellent NIR‐II theranostic capacity, which provides a new nanoplatform for anti‐tumor therapy and builds great potential for future clinical research.

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Space and Bond Synergistic Conjugation Controlling Multiple‐Aniline NIR‐II Absorption for Photoacoustic Imaging Guided Photothermal Therapy

Cited by 6 publications

References 61 publications

A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy

A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy

Transforming Commercial Polymers into Tough yet Switchable Adhesives by Trident Photoswitch Molecule Doping: Break Adhesion‐Switchability Paradox

NIR‐II Absorbed Dithienopyrrole‐Benzobisthiadiazole Based Nanosystems for Autophagy Inhibition and Calcium Overload Enhanced Photothermal Therapy

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