Investigations into tropical cyclone mitigation, especially those made by Ross Hoffman, are introduced in the beginning to elicit the weather control version of 4-Dimensional Variation (4D-Var) as a nonlinear optimal control technique and the theory of natural cybernetics. Subsequently, the concept of Conditional Nonlinear Optimal Perturbations (CNOP) and the existing connotation of natural cybernetics related to weather modification are briefly presented. After that, the primary application of CNOP, improved by comparison with 4D-Var, are stressed upon, which can make use of the observational data during the controlling process, thereby having some advantages over 4D-Var in weather control. The technique may be called 'nonlinear optimal forcing variation calculus (NOFV)' or 'nonlinear optimal forcing perturbation (NOFP)' approach, which could make controlling as close to the observation as possible. Moreover, two other applications of CNOP, i.e. inversion of the initial perturbation evolving into a tropical cyclone and the solution of perturbation yielding maximum vertical wind shear with CNOP, are further investigated. Subsequently, the application of natural cybernetics to tropical cyclone mitigation and control, is analyzed in comparison with precipitation enhancement. Meanwhile, the means to realize tropical cyclone control and mitigation are synoptically reviewed. The investigation and analysis show that CNOP approach and natural cybernetics are useful in tropical cyclone mitigation and control.