This work is focused on determining the response of a multi-cracked structure in the presence of different types of cracks vibrated due to a transit mass. The open transverse and inclined edge cracks of random crack depth are present at various locations of the cracked structure. The mass is moving on the beam at the different critical speeds of the structure. Runge-Kutta fourth order method is employed to evaluate the response of the structure numerically. The significance of different factors like the magnitude of the moving mass, moving speed, crack depth, crack inclination angle and their effects on the response of the deteriorated structure are investigated. Numerical analyses with numerous examples are carried out and validated the results with finite element analysis (FEA) and experimental investigations.