This short commentary discusses the importance of space-time intervals in scientific study. Space-time intervals underlie special relativity, general relativity, and quantum field theory. In doing so, space-time intervals underlie human conscious experience, gravity, and a theory of everything. Space-time intervals also explain many of the puzzling scientific phenomena: quantum phenomena, dark matter, dark energy, the origin and evolution of the universe, and the life force. The importance of space-time intervals cannot be overestimated. Two articles published in Neuroquantology explain how all this was established from empirical evidence and theory.