Spaceflight alters the gene expression profile of cervical cancer cells

Zhang, Zhijie; Tong, Yongqing; Wang, Jiajia; Yang, Cheng; Zhou, Guohua; Li, Yuehui; Xie, Pingli; Hu, Jinyue; Li, Guancheng

doi:10.5732/cjc.011.10174

Cited by 12 publications

(9 citation statements)

References 42 publications

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“…Cis and trans regulatory factors for the localization of the MALAT-1 lncRNA to nuclear speckles have been identified [ 47 ]. Functional studies performed on cell lines from different types of human malignancies revealed that MALAT-1 is indeed key for the maintenance of hyperproliferation and metastasizing potential [ 26 , 34 , 56 , 69 , 76 , 77 , 81 , 83 ]. In addition to being a promising biomarker for the diagnosis of a wide range of human malignancies, MALAT-1 proved to be a putative target for siRNA-mediated therapy, as recently demonstrated by Ren et al [ 54 ].…”

Section: The Great Past and Bright Future Of Lncrnas Unexpectedly Idementioning

confidence: 99%

PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis

Széll

Danis

Bata‐Csörgő

et al. 2016

Pflugers Arch - Eur J Physiol

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In the last few years with the recent emergence of high-throughput technologies, thousands of long non-coding RNAs (lncRNAs) have been identified in the human genome. However, assigning functional annotation and determining cellular contexts for these RNAs are still in its infancy. As information gained about lncRNA structure, interacting partners, and roles in human diseases may be helpful in the characterization of novel lncRNAs, we review our knowledge on a selected group of lncRNAs that were identified serendipitously years ago by large-scale gene expression methods used to study human diseases. In particular, we focus on the Psoriasis-susceptibility-Related RNA Gene Induced by Stress (PRINS) lncRNA, first identified by our research group as a transcript highest expressed in psoriatic non-lesional epidermis. Results gathered for PRINS in the last 10 years indicate that it is conserved in primates and plays a role in keratinocyte stress response. Elevated levels of PRINS expression in psoriatic non-lesional keratinocytes alter the stress response of non-lesional epidermis and contribute to disease pathogenesis. Finally, we propose a categorization for the PRINS lncRNA based on a recently elaborated system for lncRNA classification.

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Section: The Great Past and Bright Future Of Lncrnas Unexpectedly Idementioning

confidence: 99%

PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis

Széll

Danis

Bata‐Csörgő

et al. 2016

Pflugers Arch - Eur J Physiol

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“…It is significantly enriched in ribosome function and neoplasm ( 35 , 36 ). MYL6 is an ATPase cellular motor protein that is highly expressed in obesity, asthma, and cervical cancer, but the potential mechanisms are not fully known ( 37 , 38 ). These findings suggest that dysfunctions in inflammatory response, neuron apoptosis, autophagy, and the endoplasmic reticulum might participate in the MS pathology, speculation that should be validated in the future.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Five-Gene Signature to Predict Relapse-Free Survival in Multiple Sclerosis

Liang

et al. 2020

Front. Neurol.

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Background: Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system with a variable natural history of relapse and remission. Previous studies have found many differentially expressed genes (DEGs) in the peripheral blood of MS patients and healthy controls, but the value of these genes for predicting the risk of relapse remains elusive. Here we develop and validate an effective and noninvasive gene signature for predicting relapse-free survival (RFS) in MS patients.Methods: Gene expression matrices were downloaded from Gene Expression Omnibus and ArrayExpress. DEGs in MS patients and healthy controls were screened in an integrated analysis of seven data sets. Candidate genes from a combination of protein–protein interaction and weighted correlation network analysis were used to identify key genes related to RFS. An independent data set (GSE15245) was randomized into training and test groups. Univariate and least absolute shrinkage and selection operator–Cox regression analyses were used in the training group to develop a gene signature. A nomogram incorporating independent risk factors was developed via multivariate Cox regression analyses. Kaplan–Meier methods, receiver-operating characteristic (ROC) curves, and Harrell's concordance index (C-index) were used to estimate the performance of the gene signature and nomogram. The test group was used for external validation.Results: A five-gene signature comprising FTH1, GBP2, MYL6, NCOA4, and SRP9 was used to calculate risk scores to predict individual RFS. The risk score was an independent risk factor, and a nomogram incorporating clinical parameters was established. ROC curves and C-indices demonstrated great performance of these predictive tools in both the training and test groups.Conclusions: The five-gene signature may be a reliable tool for assisting physicians in predicting RFS in clinical practice. We anticipate that these findings could not only facilitate personalized treatment for MS patients but also provide insight into the complex molecular mechanism of this disease.

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“…Microgravity can be exploited to study biological mechanisms and pathways to improve our understanding of many diseases, including cancer. Previous spaceflight experiments have shown that exposure to the space environment alters immune cell growth and function [11], causes cytoskeleton and cell shape changes [12], and alters cellular gene expression including genes involved in replication and suppression of tumors [13,14]. This brings us to our second Tumors in Space hypothesis.…”

Section: The Problem Statement and Supporting Evidencementioning

confidence: 98%

Tumors in Space: Preparation for Spaceflight

Larose¹

2020

Preparation of Space Experiments

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Tumors in Space is a cutting-edge cancer research experiment at the intersection of stem-cell biology and space technology selected by the United Nations Office for Outer Space Affairs and the China Manned Space Agency for a 31-day space mission on board the China Space Station. Anchored in Norway, Tumors in Space includes an international team of exceptional scientists at several European partner organizations including the

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Spaceflight alters the gene expression profile of cervical cancer cells

Cited by 12 publications

References 42 publications

PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis

PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis

Development and Validation of a Five-Gene Signature to Predict Relapse-Free Survival in Multiple Sclerosis

Tumors in Space: Preparation for Spaceflight

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