Spaceflight increases sarcoplasmic reticulum Ca2+leak and this cannot be counteracted with BuOE treatment
Jessica L. Braun,
Val A. Fajardo
Abstract:Spending time in a microgravity environment is known to cause significant skeletal muscle atrophy and weakness via muscle unloading, which can be partly attributed to Ca2+ dysregulation. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for bringing Ca2+ from the cytosol into its storage site, the sarcoplasmic reticulum (SR), at the expense of ATP. We have recently demonstrated that, in the soleus of spaceflown mice, the Ca2+ uptake ability of the SERCA pump is severely impaired and this… Show more
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