Span of apprehension deficits in older outpatients with schizophrenia

Granholm, Eric; Asarnow, Robert F.; Verney, Steven P.; Nelson, peter; Jeste, Dilip V.

doi:10.1016/0920-9964(95)00106-9

Cited by 11 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In numerous studies (for a review, see Beatty, 1982), increased task processing load (e.g., perceptual discriminability, sentence syntax complexity, number of arithmetic multiplicands) reliably evoked greater pupillary dilation responses, regardless of the cognitive domain tapped by different tasks (e.g., visual detection, language, memory, reasoning). For example, pupillary responses recorded during digit span recall tasks systematically increased in normal individuals after each additional to-berecalled digit was presented and then returned to resting baseline size after the digits were recalled (Granholm et al, 1996b;Peavler, 1974). Larger pupillary responses reflected greater allocation of available resources in these studies, and pupillary responses no longer increased when resource pools were depleted (e.g., when digit spans exceeded available working memory resources; Granholm et al, 1996b;Peavler, 1974).…”

Section: Introductionmentioning

confidence: 94%

“…For example, pupillary responses recorded during digit span recall tasks systematically increased in normal individuals after each additional to-berecalled digit was presented and then returned to resting baseline size after the digits were recalled (Granholm et al, 1996b;Peavler, 1974). Larger pupillary responses reflected greater allocation of available resources in these studies, and pupillary responses no longer increased when resource pools were depleted (e.g., when digit spans exceeded available working memory resources; Granholm et al, 1996b;Peavler, 1974). The degree of pupillary dilation observed during cognitive tasks is directly proportional to the processing demands that task places on the brain.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Accelerated age-related decline in processing resources in schizophrenia: Evidence from pupillary responses recorded during the span of apprehension task

Granholm

Morris

Asarnow

et al. 2000

J Int Neuropsychol Soc

Self Cite

View full text Add to dashboard Cite

Cognitive impairment in schizophrenia may be related to reduced availability of information-processing resources (resource limitations hypothesis). An abnormally accelerated age-related decline in processing resource availability may also occur in older patients with schizophrenia (neurodegeneration hypothesis). To test these hypotheses, pupillary responses were recorded as an index of processing resource availability during performance of the span of apprehension (SOA) task in 33 middle-aged and older patients with schizophrenia and 37 age-comparable nonpsychiatric participants. Consistent with the resource-limitations hypothesis, the patients with schizophrenia showed impaired detection accuracy and abnormally small pupillary responses (reduced resource allocation) only in the higher processing load SOA conditions. This pattern of results suggests that the patients depleted their available processing resources at lower processing loads than the nonpsychiatric participants. Consistent with the neurodegeneration hypothesis, cross-sectional analyses showed abnormally accelerated rates of age-related decline in SOA performance and pupillary responses in the patients with schizophrenia relative to age-comparable normal participants. (JINS, 2000, 6, 30-43.)

show abstract

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 97%

Accelerated age-related decline in processing resources in schizophrenia: Evidence from pupillary responses recorded during the span of apprehension task

Granholm

Morris

Asarnow

et al. 2000

J Int Neuropsychol Soc

Self Cite

View full text Add to dashboard Cite

show abstract

“…T\venty-four schizophrenia patients and 32 normal comparison participants took part in the study. The span of apprehension task performance of 11 of the patients included in the present study was also examined and reported in Granholm, Asarnow, Verney, Nelson, and Jeste (1996). The patients with schizophrenia were recruited from inpatient and outpatient treatment settings of the Veterans Affairs San Diego Healthcare System and from the Clinical Research Center for Late-Life Psychosis and Antipsychotics at the University of California, San Diego.…”

Section: Participantsmentioning

confidence: 99%

Pupillary responses index overload of working memory resources in schizophrenia.

Granholm¹,

Morris²,

Sarkin³

et al. 1997

Journal of Abnormal Psychology

Self Cite

View full text Add to dashboard Cite

The authors examined the hypothesis that schizophrenia patients have reduced availability of working memory resources by using pupillary responses as an index of resource overload. Pupillary responses were recorded during a verbal working memory task (digit recall) in 24 schizophrenia patients and 32 normal controls. Pupil size increased with increased processing load (digit-span length) but changed little or declined when processing demands exceeded available resources (overload). The schizophrenia patients showed impaired digit recall and abnormally small pupillary responses during digit presentation only in the higher processing load conditions, but they showed abnormally small pupillary responses during digit retrieval in all processing load conditions. The results suggest reduced availability of slave store and central executive working memory resources in schizophrenia. This study serves as an example of how pupillography methods can be used to test current hypotheses regarding overload of cognitive capacities in schizophrenia patients.

show abstract

Psychiatric Disturbances of Attention

Cohen

2013

The Neuropsychology of Attention

View full text Add to dashboard Cite

Span of apprehension deficits in older outpatients with schizophrenia

Cited by 11 publications

References 13 publications

Accelerated age-related decline in processing resources in schizophrenia: Evidence from pupillary responses recorded during the span of apprehension task

Accelerated age-related decline in processing resources in schizophrenia: Evidence from pupillary responses recorded during the span of apprehension task

Pupillary responses index overload of working memory resources in schizophrenia.

Psychiatric Disturbances of Attention

Contact Info

Product

Resources

About