Spanish influenza redux: revisiting the mother of all pandemics

Honigsbaum, Mark

doi:10.1016/s0140-6736(18)31360-6

Cited by 25 publications

(26 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The year 2018 marked the 100-year anniversary of the most severe influenza pandemic in recorded history, which infected nearly 500 million and killed an estimated of 50 million people worldwide over 2 years [1]. The World Health Organization (WHO) estimated that seasonal influenza was responsible for up to 650,000 deaths worldwide annually, and in China alone there were 456,718 reported influenza cases in 2017 with up to 92,000 annual influenza-associated respiratory deaths [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitudes, and Behaviors (KAB) of Influenza Vaccination in China: A Cross-Sectional Study in 2017/2018

et al. 2019

View full text Add to dashboard Cite

Background: This study aimed to estimate influenza-like illness (ILI) prevalence, influenza-related healthcare seeking behaviors, and willingness for vaccination. Methods: A retrospective cross-sectional study based on a random dialing telephone survey was conducted from October 2017 through March 2018 to assess influenza-like illness prevalence and vaccination willingness among different demographic groups. Results: 10,045 individuals were enrolled and completed the survey. A total of 2834 individuals (28%) self-reported that they have suffered from influenza-like illness, especially children under 15 years of age. Overall willingness for influenza vaccination in the 2018/2019 influenza season was 45% and was positively associated with higher education level, recommendation from doctors, cost-free vaccination, and vaccination campaigns with employers’ support. Hospitalization and seeking medicine from pharmacies was less frequent in urban locations. People under 15 and over 60 years of age sought medical service more frequently. Conclusions: ILI prevalence differed significantly by age and geographical location/population density. Vaccination policy for motivating key populations at highest risk to vaccinate should take into consideration the awareness-raising of vaccination benefits, barriers reduction of vaccination such as cost, and recommendation via healthcare professionals.

show abstract

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitudes, and Behaviors (KAB) of Influenza Vaccination in China: A Cross-Sectional Study in 2017/2018

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The most fatal and unforgettable outbreak "mother of the pandemic" virus occurred in 1918 named as Spanish influenza. In this eruption, approximately 50 million people [12,13] were dead. H1N1 was occurred in different years (1928,1932,1936,1943,1947) during this century [7].…”

Section: H1n1 Influenzamentioning

confidence: 99%

Emerging and reemerging respiratory viral infections up to Covid-19

Çelik

Saatçi

2020

Turk J Med Sci

View full text Add to dashboard Cite

Infectious diseases remain as the significant causes of human and animal morbidity and mortality, leading to extensive outbreaks and epidemics. Acute respiratory viral diseases claim over 4 million deaths and cause millions of hospitalizations in developing countries every year. Emerging viruses, especially the RNA viruses, are more pathogenic since most people have no herd immunity. The RNA viruses can adapt to the rapidly changing global and local environment due to the high error rate of their polymerases that replicate their genomes. Currently, coronavirus disease 2019 (COVID-19) is determined as an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was first identified in 2019 in Wuhan. Herein we discuss emerging and reemerging respiratory viral infections till to SARS-CoV-2.

show abstract

“…The 1918 “Spanish Flu” was the most devastating pandemic in modern history (Honigsbaum, ). In 11 months between the spring of 1918 and the winter of 1919, it killed approximately 50 million people worldwide (Johnson & Mueller, ; Patterson & Pyle, ).…”

Section: Introductionmentioning

confidence: 99%

“…In 11 months between the spring of 1918 and the winter of 1919, it killed approximately 50 million people worldwide (Johnson & Mueller, ; Patterson & Pyle, ). The morbidity pattern, together with the rapid disease progression to multiorgan failure and death, characterizes the influenza pandemic (Honigsbaum, ). So far, its origin, its unusual epidemiologic features, and the basis of its pathogenicity remain elusive (Taubenberger & Morens, ).…”

Section: Introductionmentioning

confidence: 99%

The matrix segment of the “Spanish flu” virus originated from intragenic recombination between avian and human influenza A viruses

et al. 2019

Transbound Emerg Dis

View full text Add to dashboard Cite

The 1918 Spanish flu virus has claimed more than 50 million lives. However, the mechanism of its high pathogenicity remains elusive; and the origin of the virus is controversial. The matrix (M) segment regulates the replication of influenza A virus, thereby affecting its virulence and pathogenicity. This study found that the M segment of the Spanish flu virus is a recombinant chimera originating from avian influenza virus and human influenza virus. The unique mosaic M segment might confer the virus high replication capacity, showing that the recombination might play an important role in inducing high pathogenicity of the virus. In addition, this study also suggested that the NA and NS segments of the virus were generated by reassortment between mammalian and avian viruses. Direct phylogenetic evidence was also provided for its avian origin.

show abstract

Spanish influenza redux: revisiting the mother of all pandemics

Cited by 25 publications

References 3 publications

Knowledge, Attitudes, and Behaviors (KAB) of Influenza Vaccination in China: A Cross-Sectional Study in 2017/2018

Knowledge, Attitudes, and Behaviors (KAB) of Influenza Vaccination in China: A Cross-Sectional Study in 2017/2018

Emerging and reemerging respiratory viral infections up to Covid-19

The matrix segment of the “Spanish flu” virus originated from intragenic recombination between avian and human influenza A viruses

Contact Info

Product

Resources

About