Spanish registry of thoracic tumors (TTR): Interim analyses of comorbidities, risk associations, personal and family history of cancer

Castro, R. López; Lianes, P.; Martnez, E. Nogueron; Taín, P. Diz; Calzas, Julia; Vidal, Òscar; Moyano, M. Sereno; Muñóz, Miguel Ángel Suárez; Morales, Monica Guillot; Capdevila, Laia; Fuentes, J; Valdivia-Bautista, Javier; Dols, M. Cobo; Lario, A. Paredes; Mielgo-Rubio, Xabier; Tarruella, M. Majem; Martínez, M.; Torres, J.; Rubio-Viqueira, Belén; Provencio, Mariano

doi:10.1093/annonc/mdz266.007

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“…According to the latest reports, among all kinds of cancers, lung cancer leads to the highest morbidity and mortality [ 9 ]. More than 2 million new cases are diagnosed as NSCLC, and 1.8 million deaths are caused by NSCLC per year [ 10 ]. NSCLC can be divided into two subtypes, small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC).…”

Section: Introductionmentioning

confidence: 99%

circRNA circFAT1(e2) Elevates the Development of Non-Small-Cell Lung Cancer by Regulating miR-30e-5p and USP22

Dong

Zhang

Dai

et al. 2021

BioMed Research International

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Background. As a newly discovered regulatory RNA, circular RNA (circRNA) has become a hot spot in many tumor pieces of research. In recent years, it has been discovered that circRNAs have multiple biological effects in different stages of cancer. However, the expression pattern and mechanism of circFAT1(e2) in non-small-cell lung cancer (NSCLC) are still unclear. Methods. The expressions of circFAT1(e2) in NSCLC tissues and cell lines were studied. Functionally, CCK-8 and transwell experiments were performed in A549 and H1299. In addition, we also performed a dual-luciferase report analysis to clarify the mechanism of action of circFAT1(e2). Results. circFAT1(e2) was significantly upregulated in NSCLC tissues and cell lines. circFAT1(e2) gene knockdown could significantly inhibit the proliferation, migration, and invasion of NSCLC cells. Loss of function testing found that circFAT1(e2) functioned as an oncogene in NSCLC cells. In addition, circFAT1(e2) acted as a ceRNA to spongy miR-30e-5p, which led to the increase in USP22 and promoted cell growth. Conclusions. The circFAT1(e2)-miR-30e-5p-USP22 axis is a crucial part of the progression of NSCLC. This study suggests that circFAT1(e2) may be an important potential of prognostic prediction and treatment targets for NSCLC patients.

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Section: Introductionmentioning

confidence: 99%