Spanlastics a Novel Nanovesicular Carrier: Its Potential Application and Emerging Trends in Therapeutic Delivery

Ansari, Mohd Danish; Saifi, Zoya; Pandit, Jayamanti; Khan, Iram; Solanki, Pavitra; Sultana, Yasmin; Aqil, Mohd.

doi:10.1208/s12249-022-02217-9

Cited by 33 publications

(8 citation statements)

References 49 publications

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“…As indicated in Table , the specificity of the projected concentration acquired after the three periods of thaw–freeze was observed to be at 37 °C for a short duration while it was −20 °C for a longer duration of 14 days in the ranges of 91–102.1% SD for posaconazole and 88.2–100.5% SD for hemp seed oil. The findings suggest that neither the drug nor the oil deteriorated over the various storage settings. − …”

Section: Resultsmentioning

confidence: 91%

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

et al. 2023

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The present study involves the development of a reverse-phase HPLC method employing the quality-by-design methodology for the estimation of posaconazole and hemp seed oil simultaneously in nanomicelles formulation. The successful separation of posaconazole and hemp seed oil was achieved together, and this is the first study to develop and quantify posaconazole and hemp seed oil nanomicelles with linoleic acid as the internal standard and developed a dual drug analytical method employing a quality-by-design approach. The study was performed on a Shimadzu Prominence-I LC-2030C 3D Plus HPLC system with a PDA detector and the Shim-pack Solar C8 column (250 mm × 4.6 mm × 5 μm) for analysis with a mobile phase ratio of methanol:water (80:20% v/v) maintaining the flow rate of 1.0 mL/min. The final wavelength was selected as 240 nm and the elution of hemp seed oil and posaconazole was obtained at 2.7 and 4.6 min, respectively, with a maximum run time of 8.0 min. Box Behnken design was employed to optimize the method, keeping the retention time, peak area, and theoretical plates as dependent variables, while the mobile phase composition, flow rate, and wavelengths were chosen as independent variables. Parameters such as specificity, accuracy, robustness, linearity, sensitivity, precision, ruggedness, and forced degradation study were performed to validate the method. The calibration curves of posaconazole and hemp seed oil were determined to be linear throughout the range for concentration. The suggested approach can be effectively utilized for estimating the content of drugs from their nanoformulation and proved suitable for both in vivo and in vitro research.

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Section: Resultsmentioning

confidence: 91%

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

et al. 2023

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“…Curcumin is one of the PSs that suffer from poor bioavailability due to its hydrophobic nature [64]. It was formulated in the form of a nanospanlastic that is characterized with high elasticity and deformability making this form suitable for transdermal drug delivery [65]. A randomized controlled comparative clinical study was conducted in which 52 children diagnosed with the fungal infection of tinea capitis were enrolled.…”

Section: Tinea Capitis Treatmentmentioning

confidence: 99%

Nanotechnology and photodynamic therapy from a clinical perspective

Gaber

Fadel

2022

Transl Biophotonics

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Photodynamic therapy (PDT) is currently applied clinically in many medical centers worldwide. The clinical outcomes are from one side satisfying and from the other side highlighting the areas of further development. Issues like hydrophobicity of the photosensitizer (PS), uncontrolled distribution and limited tissue penetration of the accompanying light sources triggered the interest of many research groups. Nanotechnology outstood among the various suggested enhancement solutions. In this review, the rationale behind using nanotechnology is discussed. Light is shed on the status of nanotechnology from approval for clinical use. Clinical studies of PS‐loaded nanoparticles are summarized and the challenges facing the progress of those systems are enumerated.

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“…By allowing for enhanced drug permeation and selective delivery of both hydrophilic and lipophilic drugs for a sustained period, Spanlastics can lead to improved therapeutic effects, patient adherence, and reduced adverse effects ( Gaafar et al, 2014 ). There is growing interest in using Spanlastics for various drug delivery applications, including trans-tympanic delivery, ocular delivery, trans-ungual delivery, and topical distribution ( Ansari et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies

Yasser,

El Naggar,

Elfar

et al. 2024

International Journal of Pharmaceutics: X

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Spanlastics a Novel Nanovesicular Carrier: Its Potential Application and Emerging Trends in Therapeutic Delivery

Cited by 33 publications

References 49 publications

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

Nanotechnology and photodynamic therapy from a clinical perspective

Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies

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