Spanlastics—A novel nanovesicular carrier system for ocular delivery

Development and Evaluation of Novel Surfactant-Based Elastic Vesicular System for Ocular Delivery of Fluconazole

“…IPA was chosen as a suitable solvent for disrupting the prepared vesicles. 12 The entrapment of vesicles was determined using the dialysis bag method, 26 and the % entrapment was calculated as follows:…”

“…Antifungal treatment furthermore involves aggressive and chronic therapy. 12 Fluconazole (FLZ) is a stable, water-soluble, bis-triazole antifungal with low molecular weight (306 Da), low protein binding (*11%), and low toxicity. It is available as eye drops for the treatment of ocular mycoses.…”

The potential use of novel chitosan-coated deformable liposomes in an ocular drug delivery system

“…Deformable liposomes (DL), as a special form of liposomes, have many favorable properties. DL consists of phospholipids and edge activators (surfactants with a high radius of curvature and mobility) [16], and a higher degree of penetration of the mucous membrane compared with conventional liposomes (CL) as has been proved in many studies of their ophthalmic use [2,12]. In addition, DL are highly deformable and/or flexible and can cross pores of a size smaller than the conventional liposomal diameter without disassembling, because the lipid bilayers are affected by edge activators and exhibit a higher curvature [13].…”

Ocular delivery of cyanidin-3-glycoside in liposomes and its prevention of selenite-induced oxidative stress

“…The major issues in ocular drug delivery are rapid pre-corneal drug loss and poor corneal permeability 18 . One of the approaches that have been developed is the incorporation of the drug into cationic submicronic vectors, such as liposomes, emulsions and nanoparticles.…”