SPARC-like 1 Regulates the Terminal Phase of Radial Glia-Guided Migration in the Cerebral Cortex

Gongidi, Vik; Ring, Colleen; Moody, Matthew J.; Brekken, Rolf A.; Sage, E. Helene; Rakić, Paško; Anton, E. S.

doi:10.1016/s0896-6273(03)00818-3

Cited by 108 publications

(97 citation statements)

References 53 publications

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“…Two genes with colocalizing eQTL that might be directly related to behavior are SPARC and troponin. SPARC is involved in neural development through signaling that allows neurons to end developmental migrations (Gongidi et al 2004). SPARC has also been proposed to modulate synaptic functions and to be involved in higher cortical functions in adult mammalian brains (Lively et al 2007), making this an intriguing candidate for depth preference behavior.…”

Section: Discussionmentioning

confidence: 99%

The Phenomics and Expression Quantitative Trait Locus Mapping of Brain Transcriptomes Regulating Adaptive Divergence in Lake Whitefish Species Pairs (Coregonus sp.)

Whiteley

Derôme

Rogers³

et al. 2008

Genetics

107

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We used microarrays and a previously established linkage map to localize the genetic determinants of brain gene expression for a backcross family of lake whitefish species pairs (Coregonus sp.). Our goals were to elucidate the genomic distribution and sex specificity of brain expression QTL (eQTL) and to determine the extent to which genes controlling transcriptional variation may underlie adaptive divergence in the recently evolved dwarf (limnetic) and normal (benthic) whitefish. We observed a sex bias in transcriptional genetic architecture, with more eQTL observed in males, as well as divergence in genome location of eQTL between the sexes. Hotspots of nonrandom aggregations of up to 32 eQTL in one location were observed. We identified candidate genes for species pair divergence involved with energetic metabolism, protein synthesis, and neural development on the basis of colocalization of eQTL for these genes with eight previously identified adaptive phenotypic QTL and four previously identified outlier loci from a genome scan in natural populations. Eighty-eight percent of eQTL-phenotypic QTL colocalization involved growth rate and condition factor QTL, two traits central to adaptive divergence between whitefish species pairs. Hotspots colocalized with phenotypic QTL in several cases, revealing possible locations where master regulatory genes, such as a zinc-finger protein in one case, control gene expression directly related to adaptive phenotypic divergence. We observed little evidence of colocalization of brain eQTL with behavioral QTL, which provides insight into the genes identified by behavioral QTL studies. These results extend to the transcriptome level previous work illustrating that selection has shaped recent parallel divergence between dwarf and normal lake whitefish species pairs and that metabolic, more than morphological, differences appear to play a key role in this divergence.

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Section: Discussionmentioning

confidence: 99%

The Phenomics and Expression Quantitative Trait Locus Mapping of Brain Transcriptomes Regulating Adaptive Divergence in Lake Whitefish Species Pairs (Coregonus sp.)

Whiteley

Derôme

Rogers³

et al. 2008

Genetics

107

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“…The distribution of SPARC along radial glial processes may facilitate the apical migration of neuroblasts from the ventricular layer towards the pia mater (Rakic, 1972). The SPARC homolog, hevin, is expressed by cortical radial glia during embryogenesis and is necessary for cortical lamination (Gongidi et al, 2004). Hevin has deadhesive properties that terminate neuroblast migration at the cortical plate (Gongidi et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…The SPARC homolog, hevin, is expressed by cortical radial glia during embryogenesis and is necessary for cortical lamination (Gongidi et al, 2004). Hevin has deadhesive properties that terminate neuroblast migration at the cortical plate (Gongidi et al, 2004). Thus, SPARC and hevin may have some redundancy or complementarity of function, as they do in the foreign body response (Barker et al, 2005b), although overlap in their expression has not been fully determined.…”

Section: Discussionmentioning

confidence: 99%

SPARC is expressed by macroglia and microglia in the developing and mature nervous system

Vincent

Lau

Roskams

2008

Developmental Dynamics

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SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that is highly expressed during development, tissue remodeling, and repair. SPARC produced by olfactory ensheathing cells (OECs) can promote axon sprouting in vitro and in vivo. Here, we show that in the developing nervous system of the mouse, SPARC is expressed by radial glia, blood vessels, and other pial-derived structures during embryogenesis and postnatal development. The rostral migratory stream contains SPARC that becomes progressively restricted to the SVZ in adulthood. In the adult CNS, SPARC is enriched in specialized radial glial derivatives (Mü ller and Bergmann glia), microglia, and brainstem astrocytes. The peripheral glia, Schwann cells, and OECs express SPARC throughout development and in maturity, although it appears to be down-regulated with maturation. These data suggest that SPARC may be expressed by glia in a spatiotemporal manner consistent with a role in cell migration, neurogenesis, synaptic plasticity, and angiogenesis.

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“…Additionally, other proteins expressed in neuronal cells were detected only in NaCl-injected animals, such as Ataxin-10, Shank3 and WD repeat-containing protein 47 [39][40][41] . On the other hand, some proteins that have also been shown to be expressed by neural cells were upregulated, such as nucleophosmin (2 fold), or detected only in KA-injected animals such as SPARC-like protein 1 and Hemopexin [42][43][44] . …”

Section: Immediate Protein Expression Response After Se (1dpi)mentioning

confidence: 99%

High-Throughput LC–MS/MS Proteomic Analysis of a Mouse Model of Mesiotemporal Lobe Epilepsy Predicts Microglial Activation Underlying Disease Development

Bitsika

Duveau²,

Simon-Areces

et al. 2016

J. Proteome Res.

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Uncovering the molecular mechanisms of Mesial temporal lobe epilepsy (MTLE) is critical to identify therapeutic targets. In this study, we performed global protein expression analysis of a kainic acid (KA) MTLE mouse model at various time-points (1d, 3d, 30d post KA injection -dpi), representing specific stages of the syndrome.High resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination to label-free protein quantification, using three processing approaches for quantification, was applied. Following comparison of KA versus NaCl-injected mice, 22, 53 and 175 proteins were differentially (statistically significant) expressed at 1, 3 and 30dpi respectively, according to all 3 quantification approaches. Selected findings were confirmed by multiple reaction monitoring LC-MS/MS. As a positive control, the astrocyte marker GFAP was found to be upregulated (3dpi:1.9 fold; 30dpi:12.5 fold), also verified by IHC. The results collectively suggest that impairment in synaptic transmission occurs even right after initial status epilepticus (1dpi), with neurodegeneration becoming more extensive during epileptogenesis (3dpi) and sustained at the chronic phase (30dpi), where also extensive glial and astrocyte-mediated inflammation is evident. This molecular profile is in line with observed phenotypic changes in human MTLE, providing the basis for future studies on new molecular targets for the disease.

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SPARC-like 1 Regulates the Terminal Phase of Radial Glia-Guided Migration in the Cerebral Cortex

Cited by 108 publications

References 53 publications

The Phenomics and Expression Quantitative Trait Locus Mapping of Brain Transcriptomes Regulating Adaptive Divergence in Lake Whitefish Species Pairs (Coregonus sp.)

The Phenomics and Expression Quantitative Trait Locus Mapping of Brain Transcriptomes Regulating Adaptive Divergence in Lake Whitefish Species Pairs (Coregonus sp.)

SPARC is expressed by macroglia and microglia in the developing and mature nervous system

High-Throughput LC–MS/MS Proteomic Analysis of a Mouse Model of Mesiotemporal Lobe Epilepsy Predicts Microglial Activation Underlying Disease Development

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