Sparganii Rhizoma: A review of traditional clinical application, processing, phytochemistry, pharmacology, and toxicity

Jia, Jia; Li, Xiang; Ren, Xueyang; Liu, Xiaoyun; Wang, Yu; Dong, Ying; Wang, Xiaoping; Sun, Siqi; Xu, Xiao; Xiao, Li; Song, Ruolan; Ma, Jiamu; Yu, Axiang; Fan, Qiqi; Wei, Jing; Yan, Xin; Wang, Xiuhuan; She, Gaimei

doi:10.1016/j.jep.2020.113571

Cited by 35 publications

(23 citation statements)

References 24 publications

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“…LC was stubbornly intertwined with phlegm, blood stasis, and toxin, so drastic medicinals accurate in intervening cancer cells were frequently applied to eliminate pathogens. Pharmacological experiments demonstrated that drastic medicinals can fight against tumors (Yoon et al, 2018;Chang et al, 2020;Jia et al, 2021), promote blood circulation, and curb pain caused by oxaliplatin. However, the evidence of clinical studies was inadequate to explain that drastic medicinals had a strong tumor-suppressive effect and its rationality in clinic usage.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Principle of Combined Strengthening Qi and Eliminating Pathogens in Treating Middle-Advanced Primary Liver Cancer: A Systematic Review and Meta-Analysis

She

Huang

et al. 2021

Front. Pharmacol.

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Background: The combination of strengthening Qi and eliminating pathogens is an available therapeutic principle in traditional Chinese medicine (TCM) for primary liver cancer (PLC) at middle-advanced stage. However, there is a lack of reasonable evidence to support the proper application of this therapeutic principle. This meta-analysis aims to evaluate the efficacy and safety of Chinese medicinal formulas (CMFs), including two subgroup analyses of the principle of strengthening Qi and eliminating pathogens.Method: Clinical trials were obtained through searching of EMBASE, Web of Science, PubMed, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database, Chinese Biomedical Literature Database, and two clinical trial registries. The randomized controlled trials with the combination of CMFs and transcatheter arterial chemoembolization (TACE) in the experiment group were acceptable, in contrast to the TACE alone in the control group. The statistics analysis was performed on Review Manager 5.4.Results: A total of eligible 24 trials were accessed in this work. Overall, CMFs could improve the survival duration of 6 months, 1 year, and 2 years, Karnofsky Performance Status, tumor objective response rate (ORR), AFP, and symptom. In the subgroup analysis, trials complying with the principle of single strengthening Qi did not show any significant difference in increasing tumor ORR. Meanwhile, the principle of combined strengthening Qi and eliminating pathogens was uncertain in improving symptoms and 1-year and 2-year survival time. In addition, the outcome indexes of ALT and AST were heterogeneous. In last, the total occurrence of adverse events could not be reduced via using CMFs. Patients treated with CMFs exhibited liver injury, fever, and white blood cell decline, with mild events occurring more frequently and severe events occurring less.Conclusion: CMFs are an effective treatment method to cure PLC at the middle-advanced stage. Adopting the principle of single strengthening Qi presents better efficacy in the long term by prolonging the survival duration. Following the principle of combined strengthening Qi and eliminating pathogens could be more beneficial to patients in short term by lessening the tumor size. CMFs have the advantage of reducing certain serious adverse events.

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Section: Discussionmentioning

confidence: 99%

The Therapeutic Principle of Combined Strengthening Qi and Eliminating Pathogens in Treating Middle-Advanced Primary Liver Cancer: A Systematic Review and Meta-Analysis

She

Huang

et al. 2021

Front. Pharmacol.

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“…Through the detection of E 2 , P, ER and PR, we found that CRSR can reduce the high expression of E 2 , P, ER, and PR in the UL rats. Reduced the concentration of P and E 2 in the serum, especially the concentration of P. The concentration of E 2 , P, and their receptors in ovarian and uterine tissues were significantly reduced and tended to be at the levels of the NC group, indicating the pharmacological effects of CRSR (14,17). The significant changes in the serum, uteruses, and ovaries suggest that CRSR not only targets one location but also has multiple targets.…”

Section: Discussionmentioning

confidence: 93%

“…CRSR, a classical herb pair used to promote blood circulation and remove blood stasis, is commonly used in the treatment of gynecological tumors (13)(14)(15)(16). Curcumae Rhizoma has antitumor, antiplatelet aggregation, antithrombosis, hepatoprotective, antimicrobial, and other pharmaceutical activities.…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative Effects of Component Chinese Medicine From Curcumae Rhizoma and Sparganii Rhizoma, a Traditional Herb Pair, on Uterine Leiomyoma in a Rat Model

Zhang

et al. 2021

Front. Public Health

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Uterine leiomyoma (UL), common benign tumors in women of child-bearing age, are believed to be caused mainly by Qi stagnation and blood stasis, according to a theory of traditional Chinese medicine. Curcumae Rhizoma and Sparganii Rhizoma (CRSR) is a classical herb pair that activates blood circulation to dissipate blood stasis. The purpose of this study was to explore the prevention and treatment effects of CRSR component compatibility on UL in rats. We randomly assigned adult female non-pregnant rats into three groups: a normal control (NC) group, a UL model group, and a CRSR treatment group. We administered to the UL and CRSR groups oral gavage diethylstilbestrol and injected them with progesterone (P) to establish UL for 5 weeks. The CRSR group received a CRSR medicinal solution after daily modeling. The uterus morphology of the UL group showed significantly more swelling than did that of the NC group, and we found no significant abnormalities in the morphology of the CRSR group. The pathological changes associated with UL were relieved in the CRSR group. CRSR improved the related parameters of the uterus and ovarian coefficients, significantly reducing the concentrations of P in the serum and the concentrations of estradiol, P, estrogen receptor, and P receptor in the uterus and ovary. In addition, CRSR significantly improved the abnormal blood conditions of UL, shown by decreases in plasma viscosity, the erythrocyte sedimentation rate equation K value, and erythrocyte aggregation index. Therefore, CRSR component compatibility may prevent and cure UL through the above ways.

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“…The dried tuberous rhizome of S. stoloniferum is a widely used gynecological drug in traditional Chinese medicine (Jia et al. 2021 ). Two subspecies of S. stoloniferum , subspecies stoloniferum and Sparganium stoloniferum subsp.…”

mentioning

confidence: 99%

Characterization of the complete chloroplast genome of an aquatic plant, Sparganium stoloniferum subsp. choui (Typhaceae)

Huang

Zhang

2021

Mitochondrial DNA Part B

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Sparganium stoloniferum subsp. choui is an aquatic perennial herb distributed in Northeast China. It was published as a new species in 1992 and recognized as a subspecies of S. stoloniferum in Flora of China in 2010. The complete chloroplast genome of S. stoloniferum subsp. choui was sequenced and assembled. The genome size was 161,865 bp in length with 36.8% GC content. Its quadripartite structure consisted of the large single copy (LSC, 88,953 bp) and small single copy (SSC, 19,098 bp) regions, separated by a pair of inverted repeats (IRs) of 26,907 bp. The genome contained 114 distinct genes, including 80 protein-coding genes, 30 tRNA genes, and four rRNA genes. The phylogenetic analysis including four Sparganium species showed that two subspecies of S. stoloniferum were not monophyletic, supporting the resurrection of S. choui as a species.

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Sparganii Rhizoma: A review of traditional clinical application, processing, phytochemistry, pharmacology, and toxicity

Cited by 35 publications

References 24 publications

The Therapeutic Principle of Combined Strengthening Qi and Eliminating Pathogens in Treating Middle-Advanced Primary Liver Cancer: A Systematic Review and Meta-Analysis

The Therapeutic Principle of Combined Strengthening Qi and Eliminating Pathogens in Treating Middle-Advanced Primary Liver Cancer: A Systematic Review and Meta-Analysis

Ameliorative Effects of Component Chinese Medicine From Curcumae Rhizoma and Sparganii Rhizoma, a Traditional Herb Pair, on Uterine Leiomyoma in a Rat Model

Characterization of the complete chloroplast genome of an aquatic plant, Sparganium stoloniferum subsp. choui (Typhaceae)

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