Sparganosis in Korea

Weinstein, Paul P.; Krawczyk, H. J.; Peers, James H.

doi:10.4269/ajtmh.1954.3.112

Cited by 18 publications

(8 citation statements)

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“…Application of raw flesh/skin of poikilothermic intermediate hosts to subside sore edema and ophthalmitis is also a risk factor. 2 3 4 …”

Section: Introductionmentioning

confidence: 99%

“…The parasite might invoke symptoms as early as two months postinfection. 2 Sometimes patients could remain asymptomatic for approximately 17 years. 3 Different Spirometra spp.…”

Section: Introductionmentioning

confidence: 99%

“…However, systematic approaches of literature survey of human sparganosis in Korea have rarely appeared. 2 3 11 In the present study, we provide an overview and perspectives of human sparganosis in Korea by mining the publicly available databases during the period of 1924 to 2015.…”

Section: Introductionmentioning

confidence: 99%

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Human Sparganosis in Korea

et al. 2018

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BackgroundSparganosis is a larval cestodiasis caused by the plerocercoid of Spirometra spp. Since the first description of human sparganosis in 1924, several hundred cases have been reported in Korea. However, systematic approaches for literature surveys of Korean sparganosis have seldom appeared.MethodsWe searched publicly available databases such as PubMed, Research Information Sharing Service, and Korea Medical Citation Index with relevant Medical Subject Headings.ResultsAt least 438 Korean sparganosis cases have been described from 1924 to 2015. Preoperative diagnosis has been significantly increased since the 1980s due to popularization of serological and imaging diagnostics. Cases were largely detected from fifth decades in general, but cerebral sparganosis was detected in relatively young age groups (third and fourth decades). Sparganosis was prevalent in men (75.9%). Consumption of frog/snake and drinking unfiltered water were found in 63.4% and 16.9% of patients, respectively. Most frequently affected sites were subcutaneous tissues (49.9%), followed by the central nervous system (36.2%). Involvements of visceral organs (7.6%), ocular regions (3.6%), and muscles (2.7%) were noticed. In women, breast sparganosis constituted a large proportion (34.2%). Sparganosis associated with immunocompromised patients has recently been reported.ConclusionSparganosis has been continuously reported in Korea during the past 90 years, although its incidence has decreased during the last 20 years. The disease is mostly characterized by subcutaneous nodule, but infection of the worm in vital organs often results in serious illness. Continuous awareness is warranted to monitor sparganosis occurrence and associated clinical consequences.

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“…Application of raw flesh/skin of poikilothermic intermediate hosts to subside sore edema and ophthalmitis is also a risk factor. 2 3 4 …”

Section: Introductionmentioning

confidence: 99%

“…The parasite might invoke symptoms as early as two months postinfection. 2 Sometimes patients could remain asymptomatic for approximately 17 years. 3 Different Spirometra spp.…”

Section: Introductionmentioning

confidence: 99%

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Human Sparganosis in Korea

et al. 2018

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“…In addition, most cases manifest no symptoms especially in the early stages. In this respect, Weinstein et al (1954) recorded a case manifesting a migrating subcutaneous mass developed within two months after eating raw snakes. This exceptional case may be one of a few cases manifesting early human sparganosis.…”

Section: Discussionmentioning

confidence: 99%

IgG antibody responses in early experimental sparganosis and IgG subclass responses in human sparganosis

et al. 2000

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Antigenic components in the crude extracts of Spirometra mansoni plerocercoid were analyzed in early experimental infections and in IgG subclass observed in clinical sparganosis. By IgG immunoblot, sera obtained serially from experimental mice, fed 5 spargana each, were reacted with the crude extracts. Protein bands at 36-26 kDa and 103 kDa showed positive reactions since two weeks after infection. In a differential immunoblot, in which a monospecific antibody against sparganum chymase at 36 kDa was pre-treated, the reactions at 36-26 kDa disappeared, indicating that the sparganum chymase and its degradation products invoked IgG antibody reactions. When 69 patients sera of human sparganosis were examined for their IgG subclass responses, IgG4 levels showed the highest reaction which was followed by IgG1. The IgG4 antibody also reacted mainly with 36-31 kDa protease. These results indicate that 36 kDa chymase of S. mansoni plerocercoid is the main antigenic component inducing IgG antibody response in early stage of experimental sparganosis and for specific IgG subclass reactions in human sparganosis.

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“…According to previous reports in Korea, snakes have been the most important source of human sparganosis (59.8% of cases), and spargana were also detected in the tissues of frogs with the infection rate of 4% [7-10]. Other animals are also known to be intermediate hosts of Spirometra sp.…”

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confidence: 99%

Spargana in a Weasel, Mustela sibirica manchurica, and a Wild Boar, Sus scrofa, from Gangwon-do, Korea

et al. 2013

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To know the status of sparganum (plerocercoid of Spirometra erinacei) infection in the Korean wild life, several species of wild animals were captured in Gangwon-do and examined for their status of infection with spargana. From February to December 2011, a total of 62 wild boars, 5 badgers, 1 weasel, 1 Siberian chipmunk, and 53 wild rodents were captured, and their whole muscles were examined with naked eyes for the presence of spargana worms. From the weasel and 1 wild boar, a total of 5 spargana specimens were extracted. The weasel was for the first time recorded as an intermediate or paratenic/transport host of S. erinacei in Korea, and both the weasel (Mustela sibirica manchurica) and wild boar (Sus scrofa) were added to the list of wild animals carrying spargana.

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Sparganosis in Korea

Cited by 18 publications

References 0 publications

Human Sparganosis in Korea

Human Sparganosis in Korea

IgG antibody responses in early experimental sparganosis and IgG subclass responses in human sparganosis

Spargana in a Weasel, Mustela sibirica manchurica, and a Wild Boar, Sus scrofa, from Gangwon-do, Korea

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