Sparing healthy lung by focusing the radiation beam flow onto the emphysematous regions in the treatment of lung cancer

Abstract

Introduction: Currently, routine radiotherapy (RT) planning for locally advanced lung cancer (LC) does not take into consideration the functional state of the lung. The goal of this study was to determine if it is technically feasible to integrate the sites of pulmonary emphysema (PE) into the RT planning process. Methods: Ten patients with LC and PE treated with helical Tomotherapy© were retrospectively included. After extraction by Myrian© software based on diagnostic CT (DCT), the PE data were transferred to the treatment planning system (TPS). PE-optimized plans were performed for patients with significant PE, where the dose was focused onto the PE. We compared the PE-optimized RT plans to the initial RT plans. Results: The median dose to the planning target volume (PTV) was 52 Gy (range, 36-66) in fractions of 2-3 Gy. The median PE volume was 220 cm

Comparison of Laboratory Results and Chest Computed Tomography Scans of COVID-19 Patients: A Pilot Study

“…In various diseases, volumes of organs and/or masses are measured using computer software. Measurement of lung volume is similarly carried out [9][10][11][12] . The most common patterns on CCT scans of COVID-19 patients are ground-glass opacity (GGO), interlobular septal thickening, bilateral irregular consolidations and air bronchograms.…”