Sparse serological evidence of Plasmodium vivax transmission in the Ouest and Sud-Est departments of Haiti

Weppelmann, Thomas A.; Fricken, Michael E. von; Lam, Brandon; Telisma, Taina; Existe, Alexandre; Lemoine, Jean Frantz; Larkin, Joseph; Okech, Bernard A.

doi:10.1016/j.actatropica.2016.05.011

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…Whereas, 32.9% individuals were not showing any antibody response against PvAMA-1 and PvMSP-1 19 antigens, might have slower immune response which stimulated antibodies but not up to the detectable level. This study observed PvMSP-1 19 to be highly immunogenic when compared to PvAMA-1 at all three study sites and similar observation was reported in previous immune-epidemiologic study conducted in north India [26] and other countries like Brazil and Haiti [11, 31, 37–39]. A genome-scale protein microarray study of seroreactivity to different P. vivax and P. falciparum antigens conducted at these three field sites and in Goa (Southwest India) also reported merozoites surface proteins as the most immunogenic antigen in P. vivax and reported apical membrane antigen as most immunogenic in P. falciparum [40, 41].…”

Section: Discussionsupporting

confidence: 90%

Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India

Kale

Yadav

Rao

et al. 2019

Malar J

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BackgroundIdentifying highly immunogenic blood stage antigens which can work as target for naturally acquired antibodies in different eco-epidemiological settings is an important step for designing malaria vaccine. Blood stage proteins of Plasmodium vivax, apical membrane antigen-1 (PvAMA-1) and 19 kDa fragment of merozoite surface protein (PvMSP-119) are such promising vaccine candidate antigens. This study determined the naturally-acquired antibody response to PvAMA-1 and PvMSP-119 antigens in individuals living in three geographically diverse malaria endemic regions of India.MethodsA total of 234 blood samples were collected from individuals living in three different eco-epidemiological settings, Chennai, Nadiad, and Rourkela of India. Indirect ELISA was performed to measure human IgG antibodies against recombinant PvAMA-1 and PvMSP-119 antigens. The difference in seroprevalence and factors associated with antibody responses at each site was statistically analysed.ResultsThe overall seroprevalence was 40.6% for PvAMA-1 and 62.4% for PvMSP-119. Seroprevalence to PvAMA-1 was higher in Chennai (47%) followed by Nadiad (46.7%) and Rourkela (27.6%). For PvMSP-119, seroprevalence was higher in Chennai (80.3%) as compared to Nadiad (53.3%) and Rourkela (57.9%). Seroprevalence for both the antigens were found to be higher in Chennai where P. vivax is the dominant malaria species. In addition, heterogeneous antibody response was observed for PvAMA-1 and PvMSP-119 antigens at each of the study sites. Two factors, age and malaria positivity were significantly associated with seropositivity for both the antigens PvAMA-1 and PvMSP-119.ConclusionThese data suggest that natural acquired antibody response is higher for PvMSP-119 antigen as compared to PvAMA-1 antigen in individuals living in three geographically diverse malaria endemic regions in India. PvMSP-119 appears to be highly immunogenic in Indian population and has great potential as a malaria vaccine candidate. The differences in immune response against vaccine candidate antigens in different endemic settings should be taken into account for development of asexual stage based P. vivax malaria vaccine, which in turn can enhance malaria control efforts.

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Section: Discussionsupporting

confidence: 90%

Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India

Kale

Yadav

Rao

et al. 2019

Malar J

View full text Add to dashboard Cite

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“…Though Haiti has been reported to have little evidence of P. vivax infections and low-level transmission of P. falciparum, the relatively high prevalence of glucose-6-dehydrogenase deficiency, rugged conditions, and tropical climates made Haiti an excellent location for a field trial of this new point-ofcare diagnostic. [17][18][19][20] In a previous evaluation of a qualitative G6PD rapid diagnostic test (BinaxNOW G6PD Test) differences in the humidity and temperature in the field compared with laboratory conditions led to low reliability of the assay. 9 Although the average field conditions during sample FIGURE 4.…”

Section: Discussionmentioning

confidence: 99%

Field Trial of the CareStart Biosensor Analyzer for the Determination of Glucose-6-Phosphate Dehydrogenase Activity in Haiti

Weppelmann

Fricken

Wilfong

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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Throughout many developing and tropical countries around the world, malaria remains a significant threat to human health. One barrier to malaria elimination is the ability to safely administer primaquine chemotherapy for the radical cure of malaria infections in populations with a high prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency. In the current study, a field trial of the world's first quantitative, point-of-care assay for measuring G6PD activity was conducted in Haiti. The performance of the CareStart Biosensor Analyzer was compared with the gold standard spectrophotometric assay and genotyping of the allele in schoolchildren ( = 343) from the Ouest Department of Haiti. In this population, 19.5% of participants (67/343) had some form of G6PD deficiency (< 60% residual activity) and 9.9% (34/343) had moderate-to-severe G6PD deficiency (< 30% residual activity). Overall, 18.95% of participants had the presence of the A-allele (65/343) with 7.87% (27/343) considered at high risk for drug-induced hemolysis (hemizygous males and homozygous females). Compared with the spectrophotometric assay, the sensitivity and specificity to determine participants with < 60% residual activity were 53.7% and 94.6%, respectively; for participants with 30% residual activity, the sensitivity and specificity were 5.9% and 99.7%, respectively. The biosensor overestimated the activity in deficient individuals and underestimated it in participants with normal G6PD activity, indicating the potential for a systematic measurement error. Thus, we suggest that the current version of the biosensor lacks adequate sensitivity and should be improved prior to its use as a point-of-care diagnostic for G6PD deficiency.

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“…Plasmodium malariae also occurs in Haiti, but is very infrequent [25] and it is unclear whether P. vivax occurs [26]. The models for vector-control can be applied to either of these species after adjustment of the duration of the extrinsic incubation period (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Models of effectiveness of interventions against malaria transmitted by Anopheles albimanus

Briët

Impoinvil

Chitnis

et al. 2019

Malar J

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Background Most impact prediction of malaria vector control interventions has been based on African vectors. Anopheles albimanus , the main vector in Central America and the Caribbean, has higher intrinsic mortality, is more zoophilic and less likely to rest indoors. Therefore, relative impact among interventions may be different. Prioritizing interventions, in particular for eliminating Plasmodium falciparum from Haiti, should consider local vector characteristics. Methods Field bionomics data of An. albimanus from Hispaniola and intervention effect data from southern Mexico were used to parameterize mathematical malaria models. Indoor residual spraying (IRS), insecticide-treated nets (ITNs), and house-screening were analysed by inferring their impact on the vectorial capacity in a difference-equation model. Impact of larval source management (LSM) was assumed linear with coverage. Case management, mass drug administration and vaccination were evaluated by estimating their effects on transmission in a susceptible-infected-susceptible model. Analogous analyses were done for Anopheles gambiae parameterized with data from Tanzania, Benin and Nigeria. Results While LSM was equally effective against both vectors, impact of ITNs on transmission by An. albimanus was much lower than for An. gambiae . Assuming that people are outside until bedtime, this was similar for the impact of IRS with dichlorodiphenyltrichloroethane (DDT) or bendiocarb, and impact of IRS was less than that of ITNs. However, assuming people go inside when biting starts, IRS had more impact on An. albimanus than ITNs. While house-screening had less impact than ITNs or IRS on An. gambiae , it had more impact on An. albimanus than ITNs or IRS. The impacts of chemoprevention and chemotherapy were comparable in magnitude to those of strategies against An. albimanus . Chemo-prevention impact increased steeply as coverage approached 100%, whilst clinical-case management impact saturated because of remaining asymptomatic infections. Conclusions House-screening and repellent IRS are potentially highly effective against An. albimanus if people are indoors during the evening. This is consistent with historical impacts of IRS with DDT, which can be largely attributed to excito-repellency. It also supports the idea that housing improvements have played a critical role in malaria control in North America. For elimination planning, impact estimates need to be combined with feasibility and cost-analysis. Electronic supplementary material The online version of this article (10.1186/s12936-019-2899-3) contains supplementary material, which is a...

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Sparse serological evidence of Plasmodium vivax transmission in the Ouest and Sud-Est departments of Haiti

Cited by 10 publications

References 19 publications

Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India

Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India

Field Trial of the CareStart Biosensor Analyzer for the Determination of Glucose-6-Phosphate Dehydrogenase Activity in Haiti

Models of effectiveness of interventions against malaria transmitted by Anopheles albimanus

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