Sparse substance P-like immunoreactivity in intervertebral discs: Nerve fibers and endings in the rat

McCarthy, Peter W.

doi:10.3109/17453679308994593

Cited by 13 publications

(4 citation statements)

References 17 publications

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“…These fibers are also positive for acetylcholinesterase, NFP, SP, CGRP, vasoactive intestinal polypeptide (VIP), neuropeptide Y, C-flanking peptide and synaptophysin (Ashton et al 1994;Coppes et al 1997;Palmgren et al 1999). The nerves entering the rat IVD have an identical expression pattern (Weistein et al 1988;McCarthy et al 1991McCarthy et al , 1992McCarthy, 1993).…”

Section: Characterization Of Nerve Fibers Innervating Healthy Intervementioning

confidence: 99%

Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain?

et al. 2010

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The normal intervertebral disc (IVD) is a poorly innervated organ supplied only by sensory (mainly nociceptive) and postganglionic sympathetic (vasomotor efferents) nerve fibers. Interestingly, upon degeneration, the IVD becomes densely innervated even in regions that in normal conditions lack innervation. This increased innervation has been associated with pain of IVD origin. The mechanisms responsible for nerve growth and hyperinnervation of pathological IVDs have not been fully elucidated. Among the molecules that are presumably involved in this process are some members of the family of neurotrophins (NTs), which are known to have both neurotrophic and neurotropic properties and regulate the density and distribution of nerve fibers in peripheral tissues. NTs and their receptors are expressed in healthy IVDs but much higher levels have been observed in pathological IVDs, thus suggesting a correlation between levels of expression of NTs and density of innervation in IVDs. In addition, NTs also play a role in inflammatory responses and pain transmission by increasing the expression of pain-related peptides and modulating synapses of nociceptive neurons at the spinal cord. This article reviews current knowledge about the innervation of IVDs, NTs and NT receptors, expression of NTs and their receptors in IVDs as well as in the sensory neurons innervating the IVDs, the proinflammatory role of NTs, NTs as nociception regulators, and the potential network of discogenic pain involving NTs.

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Section: Characterization Of Nerve Fibers Innervating Healthy Intervementioning

confidence: 99%

Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain?

et al. 2010

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“…It is recognized that substance P-(SP-) and calcitonin gene-related peptide-(CGRP-) immunoreactive (ir) nerve fibers are present in lumbar intervertebral discs in rats (Weistein et al, 1988;McCarthy et al, 1991McCarthy et al, , 1992McCarthy et al, , 1993. There are also numerous studies showing the presence of SP-and CGRP-ir nerve fibers in human disc and vertebral endplate (Coppes et al, 1990;Konttinen et al, 1990;Ashton et al, 1994;Robert et al, 1995;Brown et al, 1997;Palmgren et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Distribution and immunocytochemical characterization of dorsal root ganglion neurons innervating the lumbar intervertebral disc in rats: A review

et al. 2004

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“…Since a radial tear from the nucleus to the surface layer of the annulus and nociceptors were observed in the outermost layer of the annulus in these cases, a rupture extending the outermost layer of the annulus was considered to be the cause of discogenic low-back pain [4,6,9,16]. In patients with discogenic acute nonspecific low-back pain in this study, the radial tears were detected by discography in all patients.…”

Section: Discussionmentioning

confidence: 70%

Discogenic pain in acute nonspecific low-back pain

et al. 2005

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Acute nonspecific lowback pain is characterized by the sudden onset and severe unendurable low-back pain without radicular pain or neurological deficit in the lower extremities. The study was carried out using 55 patients who visited our hospital for acute nonspecific low-back pain, who exhibited degeneration on T2-weighted MR images, and underwent intradiscal injection of local anesthetics,steroid and contrast medium.

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Sparse substance P-like immunoreactivity in intervertebral discs: Nerve fibers and endings in the rat

Cited by 13 publications

References 17 publications

Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain?

Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain?

Distribution and immunocytochemical characterization of dorsal root ganglion neurons innervating the lumbar intervertebral disc in rats: A review

Discogenic pain in acute nonspecific low-back pain

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