Spasmolytic activity of essential oil and various extracts of Boiss. on ileum contractions

Sadraei, Hassan; Asghari, Gholamreza; Hajhashemi, Valiollah; Kolagar, Ali Dehestani; Ebrahimi, Mehdi

doi:10.1078/0944-7113-00052

Cited by 89 publications

(52 citation statements)

References 6 publications

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“…In our study (+)-limonene (8) presented this effect. Other hydrocarbons also showed spasmolytic activity, such as α-pinene, -pinene, and γ-terpinene (Sadraei et al, 2001;Astudillo et al, 2004). Interestingly, the effect of a mixture of α-pinene and -pinene was, however, less than the sum of their separate effects.…”

Section: Resultsmentioning

confidence: 99%

Structure and Spasmolytic Activity Relationships of Monoterpene Analogues Found in Many Aromatic Plants

Sousa

Júnior

Andrade

et al. 2008

Zeitschrift Für Naturforschung C

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Rotundifolone, a monoterpene isolated from the essential oil of the leaves of Mentha ¥ villosa, is a constituent of several essential oils and known to have spasmolytic activity. The present study aimed to investigate the correlation between structure and spasmolytic activity of rotundifolone and its analogues in ileum isolated from guinea-pig. Five of the seven tested analogues were found to have a spasmolytic effect more potent than rotundifolone itself, except for pulegone and (+)-limonene. The comparison between rotundifolone and limonene oxide showed that the absence of the keto group did not decrease the relaxant effect. Comparison of the spasmolytic activity between rotundifolone and (+)-pulegone showed that the absence of the epoxy group did not decrease the relaxation of the ileum. Carvone epoxide was found to be significantly more potent than rotundifolone. The monoterpene (Ð)-carvone produced ileum relaxation and was more potent than its enantiomer (+)-carvone. (+)-Limonene and pulegone oxide showed a similar effect. The study showed that the functional groups and their position at the ring of rotundifolone contributed to the relaxation activity of the ileum. The absence of the oxygenated molecular structure is not a critical requirement for the molecule to be bioactive.

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Section: Resultsmentioning

confidence: 99%

Structure and Spasmolytic Activity Relationships of Monoterpene Analogues Found in Many Aromatic Plants

Sousa

Júnior

Andrade

et al. 2008

Zeitschrift Für Naturforschung C

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“…Nomads of southwest Iran call this plant 'Barijeh' and traditionally use its resin for the treatment of diarrhea. They eat a small piece of the resin and believe it to be a very effective anti-diarrheal herbal medicine (Sadraei et al 2001). In Iranian ancient medicine, the gum obtained from the aerial parts of this plant has been used for stomach pain, chorea, epilepsy and as a wound-healing remedy (Sayyah et al 2002;Zargari 1991).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of flower, stem and leaf extracts of <i>Ferula gummosa</i> Boiss

Ebrahimzadeh¹,

Nabavi²,

Nabavi³

et al. 2010

Grasas y Aceites

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The Antioxidant and antihemolytic activities of hydroalcoholic extracts of the flowers, stems and leaves of the Ferula gummosa Boiss were investigated employing different in vitro assay systems. Leaf extract showed better activity in DPPH radical scavenging. In addition it showed better activity in nitric oxide and H₂O₂ scavenging and Fe²⁺ chelating activity than the other parts. The extracts exhibited good antioxidant activity in linoleic acid system test but were not comparable with vitamin C (p< 0.001). The extracts showed weak reducing power activity. The F. gummosa stem extract showed better antihemolytic activity against H²O² induced hemolysis. Among the extracts, the flowers had higher phenolic and flavonoid contents. This plant is very promising for further biochemical experiments.

La actividad antihemolítica y antioxidante de extractos hidroalcohólicos de flores, tallos y hojas de Ferula gummosa Boiss fueron investigados empleando diferentes ensayos in vitro. Los extractos de hojas mostraron una mejor actividad captadora de radicales libres. Además, mostraron una mejor actividad captadora de óxido nítrico y H₂O₂ y actividad quelatante de Fe²⁺ que las otras partes. Los extractos exhibieron una buena actividad antioxidante en el ensayo con ácido linoleico pero no comparable con la vitamina C (p< 0.001). Los extractos mostraron una débil actividad de poder reductor. Los extractos de tallos de F. gummosa mostraron una mejor actividad antihemolítica contra la hemolisis inducida con H₂O₂. Entre los extractos, las flores tienen los más altos contenidos de fenoles y flavonoides. Esta planta es muy prometedora para futuros experimentos bioquímicos

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“…Essential oils of aromatic plant species have been found to be antibacterial, antifungal, spasmolytic, and antiplasmodial activity and therapeutic effect in cancer treatment (3~6, 15,23). Some oils of aromatic plant species have been shown to have applications in food preservation, pharmacological properties, and aromatherapy (7).…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial Activity Against Oral Bacteria by the Essential Oil of Artemisia iwayomogi

Cha

2007

J Bacteriol Virol

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Spasmolytic activity of essential oil and various extracts of Boiss. on ileum contractions

Cited by 89 publications

References 6 publications

Structure and Spasmolytic Activity Relationships of Monoterpene Analogues Found in Many Aromatic Plants

Structure and Spasmolytic Activity Relationships of Monoterpene Analogues Found in Many Aromatic Plants

Antioxidant activity of flower, stem and leaf extracts of <i>Ferula gummosa</i> Boiss

Chemical Composition and Antibacterial Activity Against Oral Bacteria by the Essential Oil of Artemisia iwayomogi

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