Spasmolytic Effect of Efonidipine Hydrochloride in Isolated Canine Coronary Artery: Comparison with the Effects of Nifedipine and Nisoldipine.

Jin, Hiromasa; Sato, Ryuichi; Higashino, Raita; Fukuda, Yoichi; Kurimoto, Tadashi; Tamaki, Hiroyuki

doi:10.1248/bpb.20.196

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Effect On Vascular Smooth Musclementioning

confidence: 93%

“…Efonidipine attenuated endothelin-1-induced coronary vasoconstriction in open chest dogs (67). In isolated porcine coronary artery, efonidipine potently inhibited vasoconstriction, especially that induced by endothelin-1 or by thromboxane A 2 analogue, U46619 (21,24). T-type Ca 2+ channels were shown to be involved in the regulation of renal microcirculation, although its precise distribution remains to be established (17,18).…”

Section: Effect On Vascular Smooth Musclementioning

confidence: 99%

See 1 more Smart Citation

Efonidipine Hydrochloride: A Dual Blocker of L‐ and T‐Type Ca²⁺ Channels

Tanaka

Shigenobu

2002

Cardiovascular Drug Reviews

View full text Add to dashboard Cite

T-type Ca 2+ channels have properties different from those of the L-type and are involved in cardiac pacemaking and regulation of blood flow, but not in myocardial contraction. Efonidipine is an antihypertensive and antianginal drug with dihydropyridine structure that was recently found to block both L-and T-type Ca 2+ channels. In isolated myocardial and vascular preparations, efonidipine has potent negative chronotropic and vasodilator effects but only a weak negative inotropic effect. In experimental animals and patients, reduction of blood pressure by the drug was accompanied by no or minimum reflex tachycardia leading to improvement of myocardial oxygen balance and maintenance of cardiac output. Efonidipine increased glomerular filtration rate without increasing intraglomerular pressure. By relaxing both the afferent and efferent arterioles, efonidipine markedly reduced proteinuria. Thus, efonidipine, an L-and T-type dual Ca 2+ channel blocker, appears to have an ideal profile as an antihypertensive and antianginal drug with organ-protective effects in the heart and kidney.

show abstract

Section: Effect On Vascular Smooth Musclementioning

confidence: 93%