SPATA4 improves aging‐induced metabolic dysfunction through promotion of preadipocyte differentiation and adipose tissue expansion

Li, Zhongchi; Xu, Kang; Zhao, Sen; Guo, Yanfei; Chen, Huiling; Ni, Jian-Quan; Liu, Qingfei; Wang, Zhao

doi:10.1111/acel.13282

Cited by 10 publications

(2 citation statements)

References 46 publications

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“…Although chronic systemic low-grade inflammation may induce metabolic dysfunction, acute localized inflammation can be an adaptive response with positive effects in hypodermal AT remodeling and expansion, thus triggering a response to counteract age-related pro-inflammatory changes [ 118 , 119 ]. Evidence shows that under adverse circumstances, conserved proteins such as spermatogenesis-associated protein 4 (SPATA4) show tissue-specific functions in promoting preadipocyte differentiation through activation of the extracellular regulated protein kinases (ERK) 1/2 and CCAAT-enhancer-binding proteins β (C/EBPβ) pathways and facilitating adipokine expression in aged mice [ 120 ].…”

Section: Role Of the Hypodermis In Age-related Skin Deteriorationmentioning

confidence: 99%

Aging and homeostasis of the hypodermis in the age-related deterioration of skin function

Liu,

Lu,

Feng

2024

Cell Death Dis

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Adipose tissues in the hypodermis, the crucial stem cell reservoir in the skin and the endocrine organ for the maintenance of skin homeostasis undergo significant changes during skin aging. Dermal white adipose tissue (dWAT) has recently been recognized as an important organ for both non-metabolic and metabolic health in skin regeneration and rejuvenation. Defective differentiation, adipogenesis, improper adipocytokine production, and immunological dissonance dysfunction in dWAT lead to age-associated clinical changes. Here, we review age-related alterations in dWAT across levels, emphasizing the mechanisms underlying the regulation of aging. We also discuss the pathogenic changes involved in age-related fat dysfunction and the unfavorable consequences of accelerated skin aging, such as chronic inflammaging, immunosenescence, delayed wound healing, and fibrosis. Research has shown that adipose aging is an early initiation event and a potential target for extending longevity. We believe that adipose tissues play an essential role in aging and form a potential therapeutic target for the treatment of age-related skin diseases. Further research is needed to improve our understanding of this phenomenon.

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Section: Role Of the Hypodermis In Age-related Skin Deteriorationmentioning

confidence: 99%

Aging and homeostasis of the hypodermis in the age-related deterioration of skin function

Liu,

Lu,

Feng

2024

Cell Death Dis

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“…The amounts and functions of sWAT deteriorate with advanced age, related to the reduced proliferation and differentiation capacities of preadipocytes (Li et al ., 2021). A decline in adipogenesis in sWAT in obese humans has also been associated with senescent preadipocytes (Gustafson et al ., 2019).…”

Section: Evidence and Mechanisms Of Dyslipidemia‐induced Cellular Sen...mentioning

confidence: 99%

New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

Xiang

Tian

et al. 2022

Biological Reviews

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Atherosclerosis, characterized by lipid-rich plaques in the arterial wall, is an age-related disorder and a leading cause of mortality worldwide. However, the specific mechanisms remain complex. Recently, emerging evidence has demonstrated that senescence of various types of cells, such as endothelial cells (ECs), vascular smooth muscle cells (VSMCs), macrophages, endothelial progenitor cells (EPCs), and adipose-derived mesenchymal stem cells (AMSCs) contributes to atherosclerosis. Cellular senescence and atherosclerosis share various causative stimuli, in which dyslipidemia has attracted much attention. Dyslipidemia, mainly referred to elevated plasma levels of atherogenic lipids or lipoproteins, or functional impairment of anti-atherogenic lipids or lipoproteins, plays a pivotal role both in cellular senescence and atherosclerosis. In this review, we summarize the current evidence for dyslipidemia-induced cellular senescence during atherosclerosis, with a focus on low-density lipoprotein (LDL) and its modifications, hydrolysate of triglyceride-rich lipoproteins (TRLs), and high-density lipoprotein (HDL), respectively. Furthermore, we describe the underlying mechanisms linking dyslipidemia-induced cellular senescence and atherosclerosis. Finally, we discuss the senescence-related therapeutic strategies for atherosclerosis, with special attention given to the anti-atherosclerotic effects of promising geroprotectors as well as anti-senescence effects of current lipid-lowering drugs.

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Klotho Upregulation via PPARγ Contributes to the Induction of Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning in Rats

Zhang

Liu

et al. 2022

Cell Mol Neurobiol

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SPATA4 improves aging‐induced metabolic dysfunction through promotion of preadipocyte differentiation and adipose tissue expansion

Cited by 10 publications

References 46 publications

Aging and homeostasis of the hypodermis in the age-related deterioration of skin function

Aging and homeostasis of the hypodermis in the age-related deterioration of skin function

New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

Klotho Upregulation via PPARγ Contributes to the Induction of Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning in Rats

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