Spatial analyses of ALS incidence in Denmark over three decades

Vieira, Verónica M.; Hansen, Johnni; Gredal, Ole; Weisskopf, Marc G.

doi:10.1080/21678421.2018.1432658

Cited by 5 publications

(2 citation statements)

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“…In Denmark, Norway, and Sweden, incidence and prevalence estimates ranged from 2.47 to 3.54 per 100,000 person-years and 8.0 to 8.7 per 100,000 persons, respectively. 34 – 40 Last, we found similar prevalence estimates using capture-recapture methodology and a simulation-based approach using data from independent sources, thus further confirming the accurate case ascertainment of the data sources used.…”

Section: Discussionsupporting

confidence: 72%

Incidence, Prevalence, and Geographical Clustering of Motor Neuron Disease in the Netherlands

et al. 2021

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Objective:To assess time trends in MND incidence, prevalence and mortality and investigate geographical clustering of MND cases in the Netherlands from 1998 to 2017, we analyzed data from the Netherlands Personal Records database, the Netherlands MND Center and the Netherlands Patient Association of Neuromuscular Diseases.Methods:In this prospective cohort study, Poisson regression was used to assess time trends in MND risk. We calculated age- and sex-standardized, observed and expected cases for 1,694 areas. Bayesian smoothed risk mapping was used to investigate geographical MND risk.Results:We identified 7,992 MND cases, reflecting an incidence of 2.64 (95% CI 2.62-2.67) per 100,000 person-years and a prevalence of 9.5 (95% CI 9.1-10.0) per 100,000 persons. Highest age-standardized prevalence and mortality rates occurred at a later age in men than in women (p<0.001). Unadjusted mortality rates increased by 53.2% from 2.57 in 1998 to 3.86 per 100,000 person-years in 2017. After adjustment for age and sex, an increase in MND mortality rate of 14.1% (95% CI 5.7%-23.2%, p<0.001) remained. MND relative risk ranged from 0.78 to 1.43 between geographical areas; multiple urban and rural high-risk areas were identified.Conclusions:We found a significant national increase in MND mortality from 1998 through 2017, only partly explained by an ageing Dutch population, and also a geographic variability in MND risk, suggesting a role for environmental or demographic risk factors.

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Section: Discussionsupporting

confidence: 72%

Incidence, Prevalence, and Geographical Clustering of Motor Neuron Disease in the Netherlands

et al. 2021

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“…R (version 3.3.3) and ArcGIS were used for data analyses. For spatial analyses and map creation, we used the R MapGAM package (39). This research was approved by the human subjects institutional review boards of the University of California, Irvine, Brigham and Women's Hospital, Boston and the MADPH.…”

Section: New Bedford Cohort (Nbc) Sensitivity Analysesmentioning

confidence: 99%

Prenatal environmental exposures and associations with teen births

DeVille

Khalili

Levy

et al. 2020

J Expo Sci Environ Epidemiol

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Background: Children's prenatal exposure to multiple environmental chemicals may contribute to subsequent deficits in impulse control, predisposing them to risk-taking.Objective: Our goal was to investigate associations between prenatal exposure mixtures and risk of teen birth, a manifestation of high-risk sexual activity, among 5,865 girls (1 st generation) born in southeast Massachusetts from 1992-1998. Methods:Exposures included prenatal modeled polychlorinated biphenyls (PCBs), ρ,ρ′dichlorodiphenyl dichloroethylene (DDE), hexachlorobenzene (HCB), lead (Pb), and mercury (Hg). We fit adjusted generalized additive models with multivariable smooths of exposure mixtures, 1 st generation infant's birth year, and maternal age at 1 st generation birth. Predicted odds ratios (ORs) for teen birth were mapped as a function of joint exposures. We also conducted sensitivity analyses among 1 st generation girls with measured exposure biomarkers (n=371). Results:The highest teen birth risk was associated with a mixture of high prenatal HCB, Hg, Pb, and PCB, but low DDE exposure, with similar associations in sensitivity analyses. The highest OR predicted for girls born in 1995 to mothers of median age (26 years) was at the 95 th percentile of Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms

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Airborne lead and polychlorinated biphenyls (PCBs) are associated with amyotrophic lateral sclerosis (ALS) risk in the U.S

Andrew

Zhou

Gui

et al. 2022

Science of The Total Environment

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Spatial analyses of ALS incidence in Denmark over three decades

Abstract: ALS incidence in Denmark is associated with both location at birth and diagnosis, suggesting that geographic variation may be due to exposures occurring at birth or closer to diagnosis, although the latter could relate to case ascertainment issues.

Cited by 5 publications

References 47 publications

Incidence, Prevalence, and Geographical Clustering of Motor Neuron Disease in the Netherlands

Incidence, Prevalence, and Geographical Clustering of Motor Neuron Disease in the Netherlands

Prenatal environmental exposures and associations with teen births

Airborne lead and polychlorinated biphenyls (PCBs) are associated with amyotrophic lateral sclerosis (ALS) risk in the U.S

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