The persistent increase in the occurrence of building collapse with attendant loss of lives in recent years has become a source of national concern in Nigeria. Hence, there is a need to strategically address gaps in proactive and reactive measures directed at preventing the occurrence of building collapse. This study explored how built environment professionals in government agencies, public and private institutions conceive the causes of building collapse, and the disaster risk reduction measures put in place by the state government to prevent and respond to the incidence of building collapse in Lagos state. The purposive snowball sampling technique was adopted to select 42 respondents for in-depth interviews. The findings revealed that building collapse is a common phenomenon in the study area and is primarily caused by institutional failure and human factors. The research further established that most collapsed buildings were old residential buildings. It was also discovered that the disaster risk reduction strategies put in place to curb the occurrence of building collapse were not holistic and effective. The study recommended continuous sensitization of building developers and provision of modern facilities such as drones and global positioning systems by the government for effective monitoring of building development in the state.