Spatial analysis of melioidosis distribution in a suburban area

Corkeron, Maree; Norton, Robert; Nelson, Paul N.

doi:10.1017/s0950268809991634

Cited by 28 publications

(34 citation statements)

References 22 publications

(33 reference statements)

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“…8,9 Environmental conditions including rainfall 5,6 and soil hydrology 26 have been shown to be important in the acquisition of Burkholderia pseudomallei infections in Southeast Asia and Australia, and the epidemiological rainfall interactions for this organism can be complex and vary by geographical region. 10 Meningococcal meningitis is the cause of seasonal dry-season epidemics in regions of sub-Saharan Africa north of Uganda, 18 and such cases can produce PIH.…”

Section: Discussionmentioning

confidence: 99%

Rainfall drives hydrocephalus in East Africa

Ranjeva¹,

Sauer

Warf³

2012

PED

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Object Hydrocephalus is one of the most common brain disorders in children throughout the world. The majority of infant hydrocephalus cases in East Africa appear to be postinfectious, related to preceding neonatal infections, and are thus preventable if the microbial origins and routes of infection can be characterized. In prior microbiological work, the authors noted evidence of seasonality in postinfectious hydrocephalus (PIH) cases. Methods The geographical address of 696 consecutive children with PIH who were treated over 6 years was fused with satellite rainfall data for the same time period. A comprehensive time series and spatiotemporal analysis of cases and rainfall was performed. Results Four infection-onset peaks were found to straddle the twice-yearly rainy season peaks, demonstrating that the infections occurred at intermediate levels of rainfall. Conclusions The findings in this study reveal a previously unknown link between climate and a neurosurgical condition. Satellite-derived rainfall dynamics are an important factor in driving the infections that lead to PIH. Given prior microbial analysis, these findings point to the importance of environmental factors with respect to preventing the newborn infections that lead to PIH.

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Section: Discussionmentioning

confidence: 99%

Rainfall drives hydrocephalus in East Africa

Ranjeva¹,

Sauer

Warf³

2012

PED

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“…; Corkeron et al . ). Cases of melioidosis among humans and livestock are said to be increasing in Malaysia in recent times (Raja ).…”

Section: Introductionmentioning

confidence: 97%

Case-control investigation on the risk factors of melioidosis in small ruminant farms in Peninsular Malaysia

et al. 2015

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“…Soil and various freshwater sources serve as the primary reservoir for B. pseudomallei (1); temporal and spatial clustering of melioidosis cases reflects a nonrandom prevalence of the organism in the environment (2,3). Once considered endemic to only the dry tropical regions of Australasia and Southeast Asia, this serious disease is now reported more frequently from more regions of the globe (4).…”

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confidence: 99%

Biogeography of Burkholderia pseudomallei in the Torres Strait Islands of Northern Australia

et al. 2013

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It has been hypothesized that biogeographical boundaries are a feature of Burkholderia pseudomallei ecology, and they impact the epidemiology of melioidosis on a global scale. This study examined the relatedness of B. pseudomallei sourced from islands in the Torres Strait of Northern Australia to determine if the geography of isolated island communities is a determinant of the organisms' dispersal. Environmental sampling on Badu Island in the Near Western Island cluster recovered a single clone. An additional 32 clinical isolates from the region were sourced. Isolates were characterized using multilocus sequence typing and a multiplex PCR targeting the flagellum gene cluster. Gene cluster analysis determined that 69% of the isolates from the region encoded the ancestral Burkholderia thailandensis-like flagellum and chemotaxis gene cluster, a proportion significantly lower than that reported from mainland Australia and consistent with observations of isolates from southern Papua New Guinea. A goodness-of-fit test indicated that there was geographic localization of sequence types throughout the archipelago, with the exception of Thursday Island, the economic and cultural hub of the region. Sequence types common to mainland Australia and Papua New Guinea were identified. These findings demonstrate for the first time an environmental reservoir for B. pseudomallei in the Torres Strait, and multilocus sequence typing suggests that the organism is not randomly distributed throughout this region and that seawater may provide a barrier to dispersal of the organism. Moreover, these findings support an anthropogenic dispersal hypothesis for the spread of B. pseudomallei throughout this region.

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Spatial analysis of melioidosis distribution in a suburban area

Cited by 28 publications

References 22 publications

Rainfall drives hydrocephalus in East Africa

Rainfall drives hydrocephalus in East Africa

Case-control investigation on the risk factors of melioidosis in small ruminant farms in Peninsular Malaysia

Biogeography of Burkholderia pseudomallei in the Torres Strait Islands of Northern Australia

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