Spatial analysis to assess the relationship between human and bovine brucellosis in South Korea, 2005–2010

Lim, Jun‐Sik; Min, Kyung‐Duk; Ryu, Sukhyun; Hwang, Seung-Sik; Cho, Sung-Il

doi:10.1038/s41598-019-43043-7

Cited by 9 publications

(5 citation statements)

References 42 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brucellosis is prevalent in Italy, Germany, Turkey, Iran, Kazakhstan, China, and other countries, along with the Silk Road. Moreover, a considerable number of Brucella strains characteristic of pathogenic bacteria population and Brucella biovars was similar to the previous study; B. melitensis is the most important zoonotic agent, followed by B. abortus and B. suis (35,36). This correlates with the fact that the worldwide control of bovine brucellosis (due to B. abortus) has been achieved to a greater extent than the control of sheep and goat brucellosis (due to B. melitensis), these latter species being the most important domestic animals in many developing countries (17).…”

Section: Discussionsupporting

confidence: 88%

Investigation of Genetic Relatedness of Brucella Strains in Countries Along the Silk Road

et al. 2021

View full text Add to dashboard Cite

In this study, MLVA (multiple-locus variable-number tandem repeat analysis) genotype data of Brucella strains from 11 countries along the Silk Road were downloaded from the MLVAbank. MLVA data of strains were applied to the constructed Minimum Spanning Tree to explore the species/biovars distribution, geographic origins, and genetic relationships of the strains analyzed. Moreover, whole-genome sequencing–single-nucleotide polymorphism (WGS-SNP) phylogenetic analysis of the genome of Brucella melitensis strains from GenBank was performed to discriminate the relatedness of strains further and investigate the transmission pattern of B. melitensis brucellosis. A total of 1,503 Brucella strains were analyzed in this study: 431 Brucella abortus strains (29.8%), 1,009 B. melitensis strains (65.7%), and 63 Brucella suis strains (4.5%). B. melitensis biovar 3 was the dominant species and was shown to be widespread in all of the examined regions, suggesting that the prevention and surveillance of the B. melitensis population are a main challenge in these countries. A wide host spectrum was observed for this Brucella population; many animal reservoirs are a potential reason for the continuous brucellosis circulation in these countries. Although the B. abortus strains from the examined regions had common geographic origins, only a few shared genotypes were observed in different countries. These data revealed that the majority of B. abortus strains were spreading within the national borders. However, the B. melitensis strains from Italy originated from a Western Mediterranean lineage; strains from the other 10 countries originated from Eastern Mediterranean lineage, and this lineage was shared by strains from three to nine different countries, suggesting that the introduction and reintroduction of the disease in the 10 countries might have occurred in the past. Furthermore, the most shared MLVA-16 genotypes were formed in the B. melitensis strains from China, Kazakhstan, and Turkey, suggesting that the introduction and trade in sheep and goats have occurred frequently in these countries. WGS-SNP analysis showed that the B. melitensis in this study originated from the Malta (Italy) region. According to their territorial affiliation between four clade strains from these countries in genotype B, the absence of a clear differentiation suggests that strains continuously expand and spread in countries along with Silk Road. Active exchange and trade of animals (sheep and goats) among these countries are reasonable explanations. B. suis strains from different nations showed unique geographic origins and epidemiological characteristics. Therefore, there is an urgent need for the control of transfer and trade of infected sheep (goats) in countries along the Silk Road, namely, the strengthening of the entry–exit quarantine of sheep and goats and improvements in the diagnosis of animal brucellosis.

show abstract

Section: Discussionsupporting

confidence: 88%

Investigation of Genetic Relatedness of Brucella Strains in Countries Along the Silk Road

et al. 2021

View full text Add to dashboard Cite

show abstract

“…13 A previous study in Jordan in children , 15 years of age reported high seropositivity in Ma'an and Mafraq (the northern Badia) governorates. 11 Regional differences of human brucellosis within the same country were also reported in the Republic of Georgia, 14,15 South Korea, 16 and China. 17 Ownership of cows and camels was not associated with Brucella seropositivity in the multiple logistic regression model, but ownership of small ruminants (sheep and/or goats) was associated with seropositivity.…”

Section: Discussionmentioning

confidence: 74%

Seroprevalence and Risk Factors for Brucella Infections in Jordan

Obaidat

Malania

Arner

et al. 2022

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Brucellosis is a significant zoonotic disease and is endemic in several regions of the world. This study is aimed to determine the nationwide spatial distribution, seroprevalence, and risk factors for Brucella infections in Jordan. Serum samples of 938 individuals from 11 governorates were tested for Brucella spp. antibodies using Rose Bengal and Brucellacapt® tests. A validated questionnaire was used to collect demographic, animal ownership, and food consumption data. The seroprevalence of Brucella infection in Jordan’s population was 6.7% (95% CI, 5.2–8.5%). The multivariate model showed that location of residence, consuming raw milk/milk products, and owning small ruminants (goat and/or sheep) were significantly associated with seropositivity after controlling for age and gender. Individuals living in the northern Badia region had 8.82 greater odds (95% CI, 4.56–17.03) of seropositivity than individuals living in the Middle region of the country. Individuals who reported consumption of raw milk/milk products had 3.7 higher odds (95% CI, 2.01–6. 81) of seropositivity compared with individuals not consuming raw milk/milk products. In addition, individuals who own small ruminants (goat and/or sheep) had 2.14 higher odds (95% CI, 1.11–4.12) of seropositivity compared with individuals who do not own small ruminants. The identified geographic hotspots and small ruminants’ ownership, risk of raw milk products highlight the need for tailored training, education campaigns, and resources for controlling brucellosis in Jordan.

show abstract

“…The hotspots of human brucellosis were clustered in the southeast regions of Korea. The risk of human brucellosis increases in rural regions, with the highest risk from bovine brucellosis [ 9 ]. The first case of human brucellosis caused by B. melitensis [ 10 ] and a foodborne outbreak of human brucellosis (n = 5) in South Korea was reported between 2012 and 2013 [ 11 ].…”

Section: Asiamentioning

confidence: 99%

Long ignored but making a comeback: a worldwide epidemiological evolution of human brucellosis

Liu,

Gao,

Wang

et al. 2024

Emerging Microbes & Infections

View full text Add to dashboard Cite

Brucellosis is a commonly neglected zoonosis that remains a serious global public health concern. The epidemiological evolution of human brucellosis has considerably changed over the past few decades, and epidemic geography is continuously expanding. Human brucellosis is emerging and re-emerging, and is imported from areas where it is endemic due to travel, immigration, and international trade. The disease continues to be prevalent in Asia and Africa, including West Asia, Central Asia, North Africa, and East Africa, with the highest incidence in Syria, Kyrgyzstan, Mongolia, Iran, Algeria, and Kenya. Re-emerging cases are frequently recorded in places where brucellosis has been controlled, such as Bosnia, Herzegovina, Azerbaijan, and the USA. In countries with a high disease burden, disease control and eradication have been extremely difficult because of livestock farming being the only source of livelihood, unique religious beliefs regarding animals, nomadic lifestyle, and low socioeconomic levels. Interventions focused on protecting livestock keepers are needed, particularly for those assisting with goat and sheep births and the consumption of raw dairy products. Notably, in most countries with a high disease burden, each period of several years with a low incidence rate was followed by a subsequent increase in cases, highlighting the necessity of continuous investment and surveillance. In addition, advocacy for the inclusion of brucellosis as a globally mandated reported disease, strict restrictions on animal movement, mandated consumption of pasteurized milk, and health education are needed. This study will help form an evidence-based strategy for international organizations to curb the future spread of brucellosis.

show abstract

Spatial analysis to assess the relationship between human and bovine brucellosis in South Korea, 2005–2010

Cited by 9 publications

References 42 publications

Investigation of Genetic Relatedness of Brucella Strains in Countries Along the Silk Road

Investigation of Genetic Relatedness of Brucella Strains in Countries Along the Silk Road

Seroprevalence and Risk Factors for Brucella Infections in Jordan

Long ignored but making a comeback: a worldwide epidemiological evolution of human brucellosis

Contact Info

Product

Resources

About