Spatial and functional properties of pseudo-alleles at the white locus in Drosophila melanogaster

The Drosophila su(Hw) gene, which controls the phenotypic effect of the gypsy transposable element, encodes a putative DNA-binding protein.

“…Additional interactions between some of the mutant alleles and their modifier loci can also take place (Rutledge et al 1988). Mutations at the suppressor of forked [su(f), 1-65.9] locus can revert the phenotype of the same forked (f, 1-56.7) (Green 1955) and lozenge (lz, 1-27.7) (Snyder and Smith 1976) alleles suppressed by su(Hw), but enhance the phenotype of w ~ (Green 1959) and lz 3z (Schalet 1970). The molecular bases of the transposable element-mediated interactions between the modifier loci and the mutant genes they affect are being studied using models such as the copia-induced w ~ and gypsy-induced yellow (y2) alleles.…”

Genetic nature of white ivory (wi) in the white locus of Drosophila melanogaster as resolved through crossing-over tests

“…The method of conducting genetic crosses was essentially similar to that of earlier workers (Green, 1959;Judd, 1959). The coupled mutant derivative of reciprocal recombination was analysed through the spottedwhite test (Green, 1959(Green, , 1969 and other tests, noted in the text. In the present study, three double mutants were employed which divided the white locus into three different sectors.…”

An analysis of the Notch locus in Drosophila melanogaster

“…that certain w alleles suppress the expression of £ homo zygotes; that is, a fly, genotypically z +/z has either zeste or normal eyes, depending upon which white allele is present. Green (1959) further noted the direct correlation be tween patterns of non-allelic phenotypic interactions and the distribution of the thirty-six alleles on the white map.…”

“…More recently, Pristrom and his colleagues (Pristrom and Yund, 1973;Rawls and Pristrom, 1975) drew similar conclusions from their bio chemical studies of complementation groups assigned to the rudimentary locus. Primarily, this type of argument has been invoked to explain the irregular patterns of complementation exhibited by spatially distinct groups within a particular complex locus (e.g, at white; Green, 1959).…”

“…Green (1959) studied the interesting interactions of thirty-six white alleles with other, non allelic, eye mutants such as "zeste" (z) and "enhancer of white-eosin" (en-w®), among others. He found, for example.…”