The plasma-water interface is a complex medium characterized by interesting physical and chemical phenomena useful for many applications such as water processing or material synthesis. In this context, optimizing the transport of reactive species from plasma to water is crucial, and it may be achieved by increasing the surface-to-volume ratio of the processed object. Herein, we study the characteristics of a streamer produced by nanosecond discharge in air gap with a droplet of deionized water. The discharge is characterized experimentally by electrical measurements as well as by 1-ns-intergated ICCD images. To report plasma properties that are not accessible through experiment, such as the spatio-temporal evolution of electron density, electric field, and space charge density, a 2D fluid model is developed and adapted to the experimental geometry. Due to the fast propagation of the ionization front, the droplet is considered as a solid dielectric. The model solves Poisson’s equation as well as the drift-diffusion equation for electrons, positive ions, and negative ions. The utilized transport coefficients are tabulated as a function of the reduced electric field. Helmholtz equations are also included in the model to account for photoionization. The electron impact ionization source obtained from the model is compared to experimental 1-ns-integrated ICCD images, and a good agreement is observed. Finally, the model is used to investigate the influence of droplet dielectric permittivity and wetting angle (the angle between a liquid surface and a solid surface) on the properties of the discharge. Overall, the data reported herein demonstrate that the model can be used to investigate plasma properties under different conditions.