Spatial and Temporal Patterns of Pharmaceuticals in the Aquatic Environment: A Review

Stamm, Christian; Alder, Alfredo C.; Fenner, Kathrin; Hollender, Juliane; Krauß, Martin; McArdell, Christa S.; Ort, Christoph; Schneider, Manuel K.

doi:10.1111/j.1749-8198.2008.00104.x

Cited by 23 publications

(11 citation statements)

References 103 publications

(200 reference statements)

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“…Pharmaceutical compounds are highly bioactive, and therefore, undesired effects in organisms cannot be excluded after their discharge into the aquatic environment, where, owing to their polarity, they tend to be quite mobile (Figure 1) (139). Even though the presence of pharmaceuticals in wastewater and natural water could be expected from their large production and widespread use, only developments in analytical chemistry (LC-MS/MS) allowed the analysis of these compounds in the nanogram to microgram per liter range, which is typical for wastewater and aquatic systems (135,140).…”

Section: Pharmaceuticals In Wastewater and Drinking Watermentioning

confidence: 99%

Global Water Pollution and Human Health

Schwarzenbach

Egli

Hofstetter

et al. 2010

Annu. Rev. Environ. Resour.

1,626

753

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Water quality issues are a major challenge that humanity is facing in the twenty-first century. Here, we review the main groups of aquatic contaminants, their effects on human health, and approaches to mitigate pollution of freshwater resources. Emphasis is placed on chemical pollution, particularly on inorganic and organic micropollutants including toxic metals and metalloids as well as a large variety of synthetic organic chemicals. Some aspects of waterborne diseases and the urgent need for improved sanitation in developing countries are also discussed. The review addresses current scientific advances to cope with the great diversity of pollutants. It is organized along the different temporal and spatial scales of global water pollution. Persistent organic pollutants (POPs) have affected water systems on a global scale for more than five decades; during that time geogenic pollutants, mining operations, and hazardous waste sites have been the most relevant sources of long-term regional and local water pollution. Agricultural chemicals and wastewater sources exert shorter-term effects on regional to local scales. 109 Annu. Rev. Environ. Resourc. 2010.35:109-136. Downloaded from www.annualreviews.org by University of Wisconsin -Madison on 10/07/12. For personal use only.

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Section: Pharmaceuticals In Wastewater and Drinking Watermentioning

confidence: 99%

Global Water Pollution and Human Health

Schwarzenbach

Egli

Hofstetter

et al. 2010

Annu. Rev. Environ. Resour.

1,626

753

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“…The ubiquitous occurrence of pharmaceuticals and personal care products (PPCPs) in the environment has now been recognized as a new environmental problem and has aroused increasing concern on their fate and risks [1][2][3][4][5]. In the aquatic ecosystem, the majority of PPCPs tends to absorb light due to their structural characteristics containing functional groups like aromatic rings and heteroatoms, making them prone to undergo photolysis under UV-Vis irradiation [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Kinetic and mechanistic study of sulfadimidine photodegradation under simulated sunlight irradiation

Hao

Guo

et al. 2019

Environ Sci Eur

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Background: The extensive uses of sulfadimidine (SDMD) resulted in its presence in water bodies, and subsequent posed risks to eco-environment and human health. In this study, photodegradation of SDMD in water was studied under UV-Visible irradiation. The intermediates, degradation pathways of SDMD photodegradation and ecological risk of SDMD were investigated as well. Results: SDMD was rapidly degraded under alkaline conditions. Nitrate ion enhanced SDMD degradation under UV-Vis irradiation, while dissolved organic matter and Fe(III) inhibited its decay, and bicarbonate ion did not exert any effect. The reactive species involved in the SDMD photodegradation was singlet oxygen. Four major transformation products were identified by high-performance liquid chromatography-mass spectrometry (HPLC-MS), and the photolytic pathway was also proposed. Photoinduced hydrolysis, desulfonation and photooxidation were the major photodegradation mechanisms for SDMD. Toxicity analysis with Vibrio fischeri showed an obvious decrease in toxicity of the reaction solution, from the initial inhibition rate of 38.5% to 0% after 150-min irradiation. Conclusion: Initial pH and common water constituents influence the photo-degradation of SDMD under UV-Vis irradiation. Photodegradation of SDMD could reduce its ecological risk in the aqueous solution.

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“…Pharmaceuticals have been detected in the environment worldwide, which has become an increasing concern in recent decades due to their designed bioactivity and thus potential adverse ecological impacts (Daughton and Ternes 1999;Halling-Søren-sen et al 1998;Kolpin et al 2002;Stamm et al 2008). Many pharmaceuticals are chiral compounds with one or more chiral centers.…”

Section: Introductionmentioning

confidence: 99%

Stereoisomeric profiling of pharmaceuticals ibuprofen and iopromide in wastewater and river water, China

Wang

Huang

et al. 2013

Environ Geochem Health

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Stereoisomeric compositions can provide insights into sources, fate, and ecological risks of contaminants in the environment. In this study, stereoisomeric profiles of ibuprofen and iopromide were investigated in wastewater and receiving surface water of the Pearl River Delta, south China. The enantiomeric fraction (EF) of ibuprofen was 0.108-0.188 and 0.480, whereas the isomer ratio (IR) of iopromide was 1.426-1.673 and 1.737-1.898 in the influent and final effluent, respectively, suggesting stereoselective degradation occurred for both pharmaceuticals during wastewater treatment. Ibuprofen showed enantioselective degradation in the anaerobic, anoxic, and aerobic conditions, whereas iopromide displayed isomer-selective degradation only under the aerobic condition. In the river waters, the EF of ibuprofen was 0.130-0.327 and the IR of iopromide was 1.500-2.531. The results suggested that pharmaceuticals in the mainstream Pearl River were mainly from discharge of treated wastewater, whereas in the tributary rivers and urban canals, direct discharge of untreated wastewater represented a significant contribution. The IR of iopromide can be an applicable and efficient tracer for wastewater discharge in the environment.

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Spatial and Temporal Patterns of Pharmaceuticals in the Aquatic Environment: A Review

Cited by 23 publications

References 103 publications

Global Water Pollution and Human Health

Global Water Pollution and Human Health

Kinetic and mechanistic study of sulfadimidine photodegradation under simulated sunlight irradiation

Stereoisomeric profiling of pharmaceuticals ibuprofen and iopromide in wastewater and river water, China

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