Spatial and temporal requirement of Mlp60A isoforms during muscle development and function in Drosophila melanogaster

Wishard, Rohan; Mohan, J.; Ramesh, S. R.; Nongthomba, Upendra

doi:10.1016/j.yexcr.2022.113430

Experimental Cell Research

2023

DOI: 10.1016/j.yexcr.2022.113430

|View full text |Cite

Spatial and temporal requirement of Mlp60A isoforms during muscle development and function in Drosophila melanogaster

Rohan Wishard

J. Mohan

S. R. Ramesh

et al.

Help me understand this report

View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The interplay between Zfh1 and Nau orchestrates the myogenic stage-dependent expression ofRbfox1and its targetStat92Evia amir-9a-mediated negative feedback loop inDrosophila melanogaster

Mukherjee,

Nongthomba

2024

Preprint

View full text Add to dashboard Cite

RNA-binding Fox protein 1 (Rbfox1) controls gene expression at various levels: as a transcription co-factor, a splicing factor, and a regulator of mRNA stability and translation. Rbfox1 and its vertebrate orthologues have critical functions during development.Rbfox1mRNA, during adult myogenesis inDrosophila,exhibits bimodal expression, suggestive of the presence of a negative feedback loop. However, there are no known negative regulators ofRbfox1expression for this context. In this study, we show that the microRNAmir-9afunctions as a repressor ofRbfox1expression. Furthermore, the expression ofmir-9ais regulated by the expression of the identity transcription factor Nau. Nau and its targetmir-9aare expressed at mid myogenesis stage, and serve to restrict the expression ofRbfox1, and its targetsStat92Eandzfh1, to the early and the late myogenesis stages, as their ectopic expression is detrimental to early myofibrillogenesis. Zfh1, in turn, repressesmir-9aexpression, completing the feedback loop. Therefore, our findings identify the mechanism by which the temporal expression of the developmental geneRbfox1and its targets are tightly regulated, essential for their functions during myogenesis.Summary statementUsingDrosophila, we show that a microRNA-mediated negative feedback loop controls the expression of genes critical for skeletal muscle development.

show abstract

The interplay between Zfh1 and Nau orchestrates the myogenic stage-dependent expression ofRbfox1and its targetStat92Evia amir-9a-mediated negative feedback loop inDrosophila melanogaster

Mukherjee,

Nongthomba

2024

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Spatial and temporal requirement of Mlp60A isoforms during muscle development and function in Drosophila melanogaster

Cited by 1 publication

References 91 publications

The interplay between Zfh1 and Nau orchestrates the myogenic stage-dependent expression ofRbfox1and its targetStat92Evia amir-9a-mediated negative feedback loop inDrosophila melanogaster

The interplay between Zfh1 and Nau orchestrates the myogenic stage-dependent expression ofRbfox1and its targetStat92Evia amir-9a-mediated negative feedback loop inDrosophila melanogaster

Contact Info

Product

Resources

About